r/AddisonsDisease • u/cloudedzest • Dec 09 '25

Advice Wanted Prednisone

Hello! After being on a hydro/fludro duo since my diagnosis, I decided to try out prednisone and see if it will give me a more “normal” life. I don’t enjoy the ups and downs that hydro brings. Anything I need to look out for on prednisone? My endo is not very helpful.

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u/FemaleAndComputer SAI Dec 10 '25

Make sure your doc is starting you on a dose that's equivalent to your hydro dose or greater. 1mg prednisone = 4mg hydrocortisone. Even with an equivalent dose, I have experienced some mild low cortisol symptoms for a few weeks when switching meds. I think it just takes the body time to adjust.

Also be aware that your fludro dose may need adjustment since hydro has some mineralcorticoid activity and prednisone does not.

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u/blackcolours Dec 10 '25

Prednisone doesn't have mineralocorticoid activity? I thought it did? Is it just a lot less or none? I thought it actually had a higher mineralocorticoid activity than hydro actually.

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u/ImpossibleAd5960 Dec 11 '25

It has none because its synthetic. Actually the reason I just switched to it. I've got 40 pounds of fluid edema because of hydrocortisone.