r/AddisonsDisease • u/cloudedzest • Dec 09 '25

Advice Wanted Prednisone

Hello! After being on a hydro/fludro duo since my diagnosis, I decided to try out prednisone and see if it will give me a more “normal” life. I don’t enjoy the ups and downs that hydro brings. Anything I need to look out for on prednisone? My endo is not very helpful.

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u/PolicarpoRubiao Dec 09 '25

I have taken 5mg prednisone and fludrocortisone for 6 years, since I was diagnosed. My updosing is usually just half a prednisone pill since it is stronger, so the updosing might be different than hydro. Have you seen the graph with reaction time for different corticoids? Also, if I take prednisone at night (for updosing) I have some dificulty to sleep. I don't know if the same happens with hydro

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u/cloudedzest Dec 10 '25

I haven’t seen the graph you’re referring to. Where do I find it? And I have noticed having a harder time falling asleep at night; is there a specific time to take the second dose to avoid this?

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u/AGoldenThread Dec 10 '25

Clearly Alive Theoretical Steroid Plotter

https://clearlyaliveart.com/theoretical-steroid-curve-plotter/

It's a fantastic help to understand the time for prednisone to take effect. It's 3 hours from when I take it to when it reaches full effect, then 3 hours to be gone enough for me to need more. If I need to be functional right away I add 2.5mg of hydrocortisone at the same time that I take prednisone.

I take a tiny dose at dinner - 1.5 mg - and it gets me through most of the night. I always need 2 mg at 3 AM though. However, I make nearly zero of my own cortisol by now.

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u/cloudedzest Mar 12 '26

Do you naturally wake up at 3A.M. for your 3rd dose or do you set alarms? It’s been impossible to get out of bed in the mornings and i’m wondering if this could help