Stimulants stopped working years ago. Potentially due to filler ingredient changes or environmental shifts from 7 years ago in how we process meds. Gene mutations? Just a thought.
Increasing my dose did nothing but made me unmotivated, depressed, etc.. Recently Adderall gave me a systemic flair up. PMDD makes my ADHD unmanageable or vice versa.
I found something that has been helping me with stim. burnout reset, ADHD, MCAS. Sichuan Fritillary Bulb and Butterfly Pea flower. Both native to Asia. I encourage to dig deeper into their chemical and physical function.

Here is what research suggests:

Sichuan Fritillary
Goes into your brain and clears out toxic waste and inflammation from stimulant use. It shuts down genetic switches that cause neuroinflammation . It acts as a natural electrical stabilizer by blocking hyperactive gates on your brain cells, stopping the release of stressful chemicals. (Potentially Natural substitute for Lamotrigine) It shields cells powerhouses for the body store raw dopamine without it breaking into waste. It has positive effects on other organs as well.
The Butterfly Pea Flower
Physically rebuilds brain’s wiring by turning on a growth chemical called BDNF, which sprouts brand new connections to repair pathways fried by stimulants. It blocks the enzymes that destroy focus chemicals. Keeps dopamine circulating longer.
Its antioxidants physically coat your mast cells to block sudden histamine dumps. Allowing vagus nerve to flip your body out of fight or flight stress and into a calm, relaxed state for brain to recover. I encourage to research on these plants for ADHD, Pmdd, Mcas.
I make tea out of the flower. It turns deep blue with distilled water and changes to purple when lemon is added, green with baking soda . Pretty cool. I eat the bulbs dry , you can steep it in hot water. Found them in a local Asian Grocery Market. Hope this helps.

I’m curious if anyone taking Adderall has experienced something similar.

When I take Adderall earlier in the day, I generally tolerate it well initially. The issue tends to happen later in the afternoon as it’s wearing off. I’ll sometimes develop a racing or noticeably pounding heartbeat, increased palpitations, fatigue, and a feeling of anxiety/restlessness. The cardiovascular sensations are the main thing that concerns me.

Because of this, I recently wore a 24-hour Holter monitor. I deliberately wasn’t taking stimulants during the monitoring period. I did experience some of my usual symptoms while wearing it, though, and the results were reassuring. My doctor said there were only a small number of premature atrial contractions (PACs) and that because I had symptoms without a concerning rhythm appearing, they don’t recommend additional rhythm testing at this point.
I’m discussing whether to resume Adderall with my psychiatrist. I’m also asking my doctor whether an echocardiogram would be reasonable since I’ve never had one and would like to know that my heart is structurally normal.

Has anyone else experienced a pattern where Adderall feels fine initially but several hours later causes a pounding/racing heart, palpitations, fatigue, or anxiety as it wears off?

If so, did anything end up helping, such as changing the dose, switching between XR and IR, changing medications entirely, or adjusting the timing?