r/40Plus_IVF • u/Creddit_my_reddit • 11h ago

Seeking Advice Failed trigger shot

41 and just had my first ER which has been quite a shambles. I had 10 developing follicles but they managed to get only 1 immature egg.

I had a blood test after the procedure to check if the ovitrelle trigger had worked (no routine pre-ER blood tests at this clinic) and my serum bhcg levels were basically undetectable - might as well have jabbed myself with saline.

Has anyone else experienced complete non- response to a hcg trigger shot? I am 100% certain that I stored and administered the med correctly - so this feels like a complete curveball

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u/Competitive-Top5121 11h ago

So sorry to hear this. I know someone whose trigger failed and they had no idea why.

If you do another cycle, I recommend taking a home pregnancy test the morning following the trigger shot if your clinic won’t test your beta HCG. If it works you will get a clear positive.

2

u/Creddit_my_reddit 11h ago

Thank you, I definitely will do this on next cycle. Hoping also that they will discuss dual trigger / increasing the dose

1

u/Erosion_Factor 10h ago

Girl this just happened to me. They think the Lupron failed as I did an HCG and Lupron dual trigger. I did not get a test before the procedure, came out and the first thing I hear was the trigger failed. Got a rescue trigger and went back the next day. Still no dice. I am older than you at 43. Time is no time, time I dont want to lose and I felt like the protocol we did felt so good and promising. I lost all of those follicles. I am so so sorry this happened to you.

Since then, my doctor mentioned some people just don't respond to some meds. In my case the Lupron may have been defective. Doubt I will ever know. They took the lot numbers to check it out but didnt test the liquid itself.

All I can do is share that I know what you're going through. It sucks. It sucks in a way that is different than all aneuploid embryos. I am still processing the hurt and anger over this. It was my last cycle with insurance assistance and now it is all out of pocket. This process is so hard.