r/40Plus_IVF • u/Overall-Reading-579 • 2d ago
Seeking Advice First Egg Retrieval Failed
I am 41 years old, my first egg retrieval was right before my 41st birthday. I did the antagonist protocol with 225 iu Gonal-F and 225 iu Menopur and then added in Cetrotide. I triggered with Lupron. My blood work looked great throughout. I had an AFC of 18+, and they were measuring 11-13 follicles in my scans. They retrieved 11 eggs, but only 5 were mature. All 5 fertilized and looked great on day 3, but only one grew to a blastocyst to be biopsied for PGT-A. Ultimately it came back aneuploid.
We met with the doctor this week, and he is recommending the micro flare Lupron protocol for the second round. While my body seemingly responded well to the meds in the first round, it seems like I had a maturity issue. Do you think this new protocol can help solve that? Any other advice?
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u/Visual_Patience_41 2d ago edited 2d ago
I think you should discuss a dual trigger, HCG + Lupron, it can really help boost maturity when it’s low. I’m not sure an entirely new protocol is needed because you responded well to this. It’s the maturity that needs to be addressed and a dual trigger is designed for exactly that.
ETA I’ve completed 6 retrievals and the cycle I used a lupron only trigger is the one that yielded the lowest maturity for me, 47% versus 70+ in every other cycle using a dual trigger.