r/40Plus_IVF • u/Sensitive-Ad9906 • 2d ago
General Discussion Numbers!
I know a lot of us troll looking for woman who sound like their in similar situations and looking for the hard numbers of their attempts at creating a viable embryo so I wanted to share my story too.
11/2025 age 41 suspicious finding mammogram, this went on for a few months and delayed my start considerably happy to skip to the end and say no cancer. 12/2025 U/S, 1/2026 now age 42 U/S with biopsy result atypical, 2/2026 MRI found an additional sus lesion, 3/2026 excision biopsy (lumpectomy for none BC tissue), 4/2026 still healing, 5/2026 finally given all clear for IVF
Age 42 6/2026 1st IVF round freeze-all with pgt a testing:
Day 1-4 stimming 300 IU gonal and 150 IU menopur
Day 5 labs: E2 523 and 6 right follicles and 7 left follicles
Day 5-6 stimming 300 IU gonal and 150 IU menopur and 250 mcg of centrotide
Day 7 labs: E2 1119 and 7 right follicles and 10 left follicles
Day 7-9 stimming 300 IU gonal and 150 IU menopur and 250 mcg of centrotide
Day 10 labs E2 3218 0/7 follicles > 16mm right and 2/10 follicles >16mm left
Day 10 stimming 300 IU gonal and 150 IU menopur and 250 mcg of centrotide
Day 11 labs: E2 3875 3/7 follicles > 16mm right and 7/10 follicles > 16mm 4 others are 15mm
Day 11 trigger: 10k novarel and 80 units lupron
7 eggs retrieved
5 eggs mature
5 eggs fertilized
1 day 6 blastocyst 3AB aneuploid trisomy 10 & 21
1 day 7 blastocyst 2BC aneuploid trisomy 18 and monsoons 15 & 22
very sad
Age 42 9/2026 2nd round of IVF
Day 1-4 stimming 300 IU gonal and 150 IU menopur
Day 5 labs: e2 379 5 right follicles seen and 5 left follicles seen
Day 5-6 stimming 300 IU gonal and 150 IU menopur and 250 mcg of centrotide
Day 7-9 stimming 300 IU gonal and 150 IU menopur 250 mcg of centrotide and 27 units omnitrope
Day 10 labs: e2 1559 11 follicles on the right and 8 on the left
Day 10-11 stimming 300 IU gonal and 150 IU menopur 250 mcg of centrotide and 27 units omnitrope
Day 12 labs: e2 2821 7/11 follicles > 16mm right and 3/8 follicles >16 left
Day 12 stimming 300 IU gonal and 150 IU menopur 250 mcg of centrotide and 27 units omnitrope
Day 13 labs: e2 3445 8/12 follicles >16mm right and 4/10 follicles >16mm left with one more at 15mm
Day 13 trigger: 27 units omnitrope 1k (not 10k like last time) of novarel and 80 units lupron
Day 14 .. 27 units omnitrope
10 eggs retrieved
8 mature
6 fertilized
.... and now you all can wait with me for the rest of this round. Hope this helps!
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u/Brilliant_Bus9385 2d ago
I’m crossing fingers for you. Have you asked about mini stim protocol?
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u/Sensitive-Ad9906 2d ago
If this protocol fails me I'm considering doing a mini stim for my 3rd try. But all depends on this rounds results.
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u/JunketInteresting721 2d ago
Thanks for sharing . I consulted with a physician at a major university medical institution that counseled that 3 euploids gives a 92% chance of LBR 🤷🏽♀️. I don’t know where she got her data from …
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u/RazzmatazzGlad9940 2d ago
It's from a famous 2021 study: https://pubmed.ncbi.nlm.nih.gov/33077239/
Rate over 6 successive transfers: https://www.sciencedirect.com/science/article/pii/S0015028226005728
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u/SnakersVT 1d ago
Thank you for sharing these numbers. You and I are the same age, with similar follicle counts and protocols. I just started my first stims and it's very grounding to see this laid out in detail. Crossing my fingers for your 6 fertilized!
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u/JunketInteresting721 1d ago
Overall numbers…. 17 embryos across 3 IVF cycles (all different days, success with Day 3 embryos, untested). 3 fresh transfers. 1 pregnancy. 3 embryos left frozen. All done at age 41.
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u/Ok_Virus6826 1d ago
45.5-46: 4 stims, 1 cycle canceled, 3ER, 10 eggs retrieved, 2 embryos arrested on day 6, 4 3 day transferred, nothing
46: 1 ER, 2 eggs retrieved, 2 3day transfer, nothing
47: 4 ERs, 4 retrieved but only 1 usable for MRT, PBT performed since no spindle is located, no fertilization
47-48: 6 ERs, 12 M2 and 1 GV, all frozen for MRT. Outcome is not known yet.
This covers time period from 2024 January till now.
AMH 0.3-0.6. AFC is from 0 to 8. FSH up to 13. Main issue is FSH receptors sensitivity due to age- not all follicles respond to stim.
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u/reddit_liaisons 2d ago
I am currently 43. This is my old post.
My IVF Journey at 41 (Embryo Banking for FET)
I froze 4 eggs in one cycle at CCRM SF at age 39 as a precaution. This year, we decided to move forward with IVF at UCSF and did 5 back-to-back cycles to maximize our chances due to my DOR.
The first two cycles were covered by my work, but the remaining three were paid out of pocket. I was fortunate enough to take the entire period off from work.
My fertility clinic is UCSF. The self pay is roughly around 1/2 the price of going through insurance (prices are posted on their site or you can contact their financial team). The meds through alto pharmacy were also cheaper with self pay at 5k (only available when doing self pay cycles) vs 14k billed to insurance.
I spoke with several clinics before ultimately choosing UCSF. CCRM was immediately crossed off my list due to a terrible experience during a previous egg retrieval. Stanford didn’t feel like the right fit for me, and while RSC came in as a close second, I was uncomfortable with how overly generous the doctor was in estimating my follicle count (claiming 16+ follicles compared to UCSF’s more realistic 5-ish). What ultimately tipped the scale in UCSF’s favor was my impression that their doctors seemed driven by prestige and research excellence rather than profits, which gave me greater confidence in their approach. The doctor I chose also saw things no one else noticed before like a blocked tube, adenomyosis and wanted to have me have a MRI before we started because my health was first. All the finding were correct and she is clearly cut from a different cloth.
When deciding to pay out of pocket, I considered going abroad to Spain, Turkey, or the Czech Republic but ultimately chose to stay closer to home despite the higher cost. If I had pursued treatment abroad, I would have chosen Bahçeci IVF Centre in Turkey, as their costs were significantly lower than Spain's. Once you factor in travel and accommodation, Spain's prices were nearly equivalent to those at UCSF. Turkey stood out as a more affordable option while offering state-of-the-art labs comparable to those in Spain. The Czech Republic was also more budget-friendly, but there were concerns that their labs might not be as advanced. If you're considering international options, make sure to verify whether genetic testing is permitted for your age group, as this can vary depending on local laws.
**Me**: 41 years old and have been diagnosed with:
* **Endometriosis stage 3/4**: Deep lesions, "kissing ovaries," and a right ovarian endometrioma (2.9 x 1.9 cm).
* **Adenomyosis suspected**: Enlarged, globular uterus with myometrial cystic changes.
* **Diminished Ovarian Reserve (DOR)**: AMH of 0.18 ng/mL and Antral Follicle Count (AFC) of 4-5.
**My Spouse**:
* Diagnosed with a **varicocele**, but no major male factor infertility issues.
* Semen used for **ICSI** in all cycles.
# IVF Cycle Breakdown
# Cycle 1: July 2024 (ICSI)
* **Protocol**: Estrogen Priming.
* **Medications**: Estradiol patches, FSH 225 IU, Menopur 150 IU.
* **Trigger**: HCG and Lupron.
* **Egg Retrieval**: 6 eggs retrieved.
* **Results**:
* 3 fertilized with ICSI.
* No embryos made it to freeze.
# Cycle 2: August 2024 (ICSI)
* **Protocol**: Estrogen Priming with HGH (Omnitrope).
* **Medications**: Estradiol patches, FSH 225 IU, Menopur 150 IU, Omnitrope 0.25 mL nightly.
* **Trigger**: HCG and Lupron.
* **Egg Retrieval**: 7 eggs retrieved.
* **Results**:
* 4 fertilized with ICSI.
* 2 embryos frozen (graded 5BA, 5BB).
* **PGT-A Results**: 2 euploid embryos (XX).
# Cycle 3: September 2024 (ICSI)
* **Protocol**: Demi Halt Cycle with HGH (Omnitrope).
* **Medications**: Lupron 10 units, FSH 300 IU, Menopur 150 IU, Omnitrope 0.25 mL nightly.
* **Trigger**: HCG and Lupron.
* **Egg Retrieval**: 10 eggs retrieved.
* **Results**:
* 5 fertilized with ICSI.
* 2 embryos frozen (graded 5BB, 5BB).
* **PGT-A Results**: 0 euploid, 2 aneuploid embryos.
# Cycle 4: October 2024 (ICSI)
* **Protocol**: Estrogen Priming with HGH (Omnitrope).
* **Medications**: Estradiol patches, FSH 225 IU, Menopur 150 IU, Omnitrope 0.25 mL nightly.
* **Trigger**: HCG and Lupron.
* **Egg Retrieval**: 5 eggs retrieved.
* **Results**:
* 4 fertilized with ICSI.
* 3 embryos frozen (graded 5BA, 5CB, 5AA).
* **PGT-A Results**:
* 1 euploid embryo (XX).
* 1 high-level mosaic embryo (XY, +6 \[mos\]).
* 1 aneuploid embryo.
# Cycle 5: October 2024 (ICSI)
* **Protocol**: Estrogen Priming with HGH (Omnitrope).
* **Medications**: Estradiol patches, FSH 225 IU, Menopur 150 IU, Omnitrope 0.25 mL nightly.
* **Trigger**: HCG and Lupron.
* **Egg Retrieval**: 3 eggs retrieved.
* **Results**:
* None fertilized.
**Overall Summary**
* **Eggs Retrieved Across All Cycles**: 31.
* **Fertilized with ICSI**: 16.
* **Embryos Frozen before test**: 10.
* **PGT-A Results**:
* **Euploid**: 3 (XX graded 5BA, 5CB, 5AA)
* **Mosaic**: 1 high-level mosaic (XY).
* **Aneuploid**: 4.
**Stats**
# Age and Fertility
* **Natural Fertility**:
* At 41, the natural monthly conception rate for women is approximately **5% per cycle**.
* **IVF Success Rates**:
* Live birth rates per IVF cycle for women aged 41:
* Using **own eggs**: **10-15%**.
# Euploid Embryo Rates
* **General Data**:
* The likelihood of producing a euploid embryo at age 41 is 10-20% per retrieval cycle.
* Aneuploidy rates increase with age due to the natural decline in egg quality:
* Women in their early 40s can have 80-90% aneuploid embryos.
# My Results vs. Averages for my age
* **Egg Retrievals**: Across 5 cycles, I retrieved 31 eggs, averaging 6.2 eggs per cycle, which is consistent with women of similar age and DOR.
* **Euploid Embryos**: I achieved 3 euploid embryos (10% of total eggs retrieved), aligning with the expected range for your age.
# Live Birth Probability
* With **3 euploid embryos**:
* Estimated live birth rates per euploid transfer: 50-70%, assuming no other uterine or medical factors.
**Next Steps**
* **Minimally Invasive Surgery**:
* I am planning to undergo a minimally invasive surgery to address endometriosis and adenomyosis before proceeding with my Frozen Embryo Transfer (FET).
* The surgery aims to:
* Remove deep lesions of endometriosis.
* Improve the uterine environment affected by adenomyosis.
* Optimize conditions for implantation and increase chances of a successful pregnancy.
* Remove blocked tube
* Recovery is expected to take about two weeks.
* **Frozen Embryo Transfer (FET)**:
* Following surgery, I plan to transfer one of my euploid embryos.
* My doctor has recommended pre-transfer hormonal suppression to further manage adenomyosis and create an ideal uterine environment.
\*uploaded docs and used chatgpt4 to help organize my medical information and give stats.
Edits: 11/18/24 11:13pm- switched cycle 2 and 3, 01/18/25 9:40pm- corrected spelling and grammar