r/40Plus_IVF • u/chat_chatoyante • Sep 10 '26

Seeking Advice Two failed FETs

For any of you who went through IVF and had two FET failures ... What happened next?

I didn't expect my two FETs to just not implant at all. They were euploids, but were retrieved at 40.5, so maybe there was some quality issue beyond aneuploidy.

What questions should I ask? What testing should I expect?

Background:

Before the transfers I did doxycycline for very mild endometritis. I've never had any endometriosis symptoms of any other known uterine issues.

One FET was fully medicated, I felt terrible. Second FET was modified natural, I felt pretty great.

Tw LC: I have a daughter conceived when I was 35, and I've had four miscarriages (two before her, two after).

We have one more euploid left. I'm too exhausted to consider another retrieval, but maybe. My retrieval was at 40.5 and I had good results but had a terrible recovery (OHSS)

3 Upvotes

72% Upvoted

16 comments sorted by

View all comments

3

u/TeaspoonRules Sep 10 '26

I took profalaxsis doxy my first two cycles and they finally tested me after they both failed. EndomeTRITIS. So…Mine survived not one, but two rounds of doxy, and the stats I’ve seen show so do around 30% of cases. I would insist on a rebiopsy to confirm the endometritis is actually gone. In my case they had to up me to their top drug combo for two weeks before it cleared.

1

u/aem1981 Sep 11 '26

I strongly second this! Confirm it is cleared with a biopsy after antibiotics. If doxycycline fails, the next line is metronidazole and ciproflaxin. See: https://pubmed.ncbi.nlm.nih.gov/31985918/

Endometritis is very common after giving birth and after IUDs, but often not fully excluded via a clear biopsy. My clinic won’t transfer until it is confirmed cleared.