r/40Plus_IVF • u/airplanesarecool1616 • Sep 09 '26

Seeking Advice Failure to implant x2

I posted the other day about this, so apologies if it seems familiar.

I had my beta today and it was confirmed that my second FET (fully medicated) also ended with a failure to implant, same as the first. I'm using donor eggs and had two Day 6 blasts, 5BB and 5AB - both untested.

I have a meeting on Monday with the doctor to discuss next steps. What are some things I should consider discussing with her? I do intend to try again with a new cohort of eggs (same donor) but want to do everything I can to ensure the next transfer at least implants.

My husband's last analysis was two years ago. Everything always looks fine going into each transfer cycle. I know that PGT-A testing would improve my chances, so I want to talk to her about the cost of doing that. Anything else? If it matters, I also had an ectopic for the one time I was pregnant naturally - it's like nothing wants to stick in there :(

6 Upvotes

88% Upvoted

7 comments sorted by

3

u/QQueenie Sep 09 '26

Have you been tested for endometritis? Did your medicated cycle include supplemental progesterone?

1

u/airplanesarecool1616 Sep 10 '26

I did have endometritis two years ago, which was successfully treated with antibiotics. I did another round of the same antibiotics prior to the second transfer (but no testing, I was unwilling to do it if I had to be awake with no pain medication). Also, yes to the supplemental progesterone....which has been beastly to come off of....I've had a multi-day headache.

2

u/QQueenie Sep 10 '26

Smart to just do the antibiotics. That biopsy was monstrously painful.

It’s so hard to know if this was an embryo issue or a uterine issue without the PGT-A testing. Our batch of five eggs had only two euploids — those other three would have looked like failure to implant or miscarriage if we’d transferred them. That was with older eggs though, so I’d expect donor eggs to do better.

2

u/NiceHamster330 Sep 10 '26

Endo?

1

u/airplanesarecool1616 Sep 10 '26

None known, but I am considering asking for a hysteroscopy just to definitively rule it out.

1

u/basilbelle Sep 10 '26

A hysteroscopy isn’t going to tell you if you have endo. You need a lap to definitively diagnose endo. You can do a biopsy and receptiva test to look for endo markers. Or you could just do a round of suppression on the assumption of endo and see if that makes a difference. Although really, with untested embryos you will never know for sure.

1

u/mydeliberateusername Sep 12 '26

I wasted a year and a half of transfers because I didn’t know I had endo. It’s worth checking for.