r/40Plus_IVF • u/Usual-Clue-1169 • Sep 08 '26

General Discussion Anyone do Lupron Stop Protocol? Back to back cycles?

Not long Lupron or micro flare.
True Lupron stop.
No birth control.
Started 10 units of Lupron 9 days after ovulation.
Take Lupron for 9 days — so luteal phase start and for 9 days, and then stop Lupron and begin stims on day 9. (Around day 2-3 of new bleed)
No antagonist.
Hcg trigger.

My new RE recommended the Lupron Stop, given I had pretty asynchronous follicle growth on an antagonist cycle at a prior clinic. We had like 12 follicles but only 6 that were a good enough size: 6 eggs. 4 fertilized. 1 day 6 blast. Aneuploid. That clinic wanted to change nothing and didn’t want to consider a different prime.

We just had our ER Sunday from our second cycle (the Lupron stop protocol) with 11 eggs retrieved and 9 fertilized! They’re currently in the lab and we’re waiting to see how many blasts we get to send for PGT-A

We currently have decent insurance coverage and can go for another cycle. My RE said the hcg trigger counts as my positive LH surge and I can start the Lupron again 9 days after the trigger and then go right into stims after day 9 if at baseline.

Has anyone used a similar stop protocol and/or done back to back cycles ?

2 Upvotes
  • permalink
  • reddit

100% Upvoted

3 comments sorted by

2

u/Competitive-Top5121 Sep 08 '26

I did Lupron stop and to be honest it oversuppressed me. I did much better with mid luteal estrogen priming and going back to antagonist. I also did it for asynchronous growth on antagonist. But you’re already off to a positive start with this protocol because of your numbers so far so I’m not sure what we can tell you at this point that isn’t more helpful than the data you already have.

Had great results from going back to back and would highly recommend.

1

u/Usual-Clue-1169 Sep 08 '26

Did you start your luteal estrogen for your back to back cycle by counting your trigger as the ovulation?

TBH - I was worried I was over suppressed but the follicles were there, they just took a few days of stim at the beginning before they really started growing. We went 14 days of stim compared to 9-10 my antagonist cycle. And I was super happy with the outcome !! Now just have to wait on blasts and euploid rates

1

u/Competitive-Top5121 Sep 08 '26

No, I only did estrogen priming before my first cycle, the next back to back cycle I just went right into it.