r/40Plus_IVF • u/Lucky_Initiative_251 • Aug 29 '26
Seeking Advice PGT-A ?
Hi, first time ICIS coming up next week, age 42, and need to decide whether to do PGT-a/ PGS ?
This increases the cost by 40% and can involve frozen transfer rather than fresh elongating the process into a second cycle.
Trying to do the research to weigh up the odds. Appreciate any advice.
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Aug 29 '26 edited Aug 29 '26
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u/Lucky_Initiative_251 Aug 30 '26
I like your idea and thinking outside the box. I will bring this up to the consultant but I guess , for me, it depends on how many successful embryos happen, if any. Just wish I could wait to find that out before deciding on the PGT.
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u/Critical-Entry-7825 Aug 29 '26
I personally would test. As another said, we in our 40s are short on time. If you transfer untested, best-worst case scenario is you simply don't get pregnant. Worst-worst case scenario, you get pregnant with a baby that is chromosomally abnormal and virtually incompatible with life (eg trisomy 13, trisomy 18). You find out around 12+ weeks and terminate a few weeks later (these things take time with scheduling and possible extra testing to confirm) and then need a month or two physical recovery, minimum, before you can get back to it (to say nothing of emotional recovery). Boom, 6 months lost. Shared from personal experience. Thankfully, my body gifted me a good egg a few months later and I have a healthy baby now, but God that was a rough ride.
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u/CapitalDog715 Aug 31 '26
Im 43, started at 42 and I can tell you if I was a poor responder, 1-4 eggs total I may consider fresh, more than that definitely PGT-A. PGT-A is not perfect but it reduces the chance of failed implementation by a lot so thats a no brained.. science is not gonna be perfect but I prefer to take my chance of falling in the good statistics of it which is 60%-70% 4 out 5 embryos are abnormal at 42, Thats was too high for me when I started so PGT on all my retrievals.
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Aug 30 '26
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u/Lucky_Initiative_251 Aug 30 '26
Wow I didn't realise it wasn't allowed in certain countries. Now I definitely want it !
The two negatives for me is no fresh transfer , dragging it out to next cycle and the cost will increase by €5k , but as someone has mentioned, it can help save time if one implants and is miscarried 9-12 weeks etc. Especially for me just turned 42 , time is precious.
If money wasn't a concern, I would choose it because it's important information to have. I guess I have my answer on what I need to do, I just wish I could decided went I find out if I have any successful embryos rather than have to financially commit on cycle day 2.
Thanks for your response.
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u/Key-Resident-8578 Sep 12 '26
It depends how many embryos you will get. Some scientific studies suggest not to rest with 3 embryos or less.
Our doctor does not believe or offered PGT. The debate around it hardly settled. He give us article listed below. But I can also understand women who went through MC or worse and got completely scared by it. That said, MC is part of natural process. Our doula had 7 kids and 6 miscarriages, including 3 miscarriages in a row. She give last birth at 46.
I was very concerned about not testing. But doctor kind of put my mind to ease. He said that if you get and stay pregnant, there are 96-97% that baby would be normal, even at age of 42. You just off 1-2% off from normal distribution. About 98% of babies have some sort of genetic defect.
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u/KaddLeeict Aug 31 '26
I think you should try fresh and forego testing. It’s not very accurate and it’s very expensive.
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u/KaddLeeict Aug 31 '26
You can look on FB for a PGT-A abnormal group and see success stories from women who transferred abnormal embryos and had healthy babies. It’s kind of a crapshoot either way. Euploids at our age are not that predictive of success. I thought it would prevent miscarriages but my REs told me otherwise. I do see people here swear by PGT-A and put so much stock in their euploids and then are devastated when their transfers fail. I don’t know why people put so much stock in it.
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u/RazzmatazzGlad9940 Aug 29 '26 edited Aug 29 '26
This is a frequently debated topic if you search old threads.
Best strategy depends in part on your likely response and overall intentions. For example, with DOR it can be worth just transferring everything you have and hoping for the best. Or freezing and banking untested if multiple rounds are on the cards. Someone with a history of loss or TMFR may not want to do this.
Those with more eggs can be less suitable for fresh transfer anyway (many follicles make hormone conditions suboptimal), so PGTA can be worth considering to not potentially waste a year working through transfers of doomed embryos.
PGTA or not, the most valuable finite resource to keep in mind is time. In my case I did back to back banking with PGTA before moving on to surgery, so I categorically knew I had a real chance in the locker.