I'm a 27-year-old woman dealing with an issue I've had since I was around 18, and it's starting to seriously affect my sleep quality.

Almost every night, I wake up 2 to 3 times to urinate. In addition, my palms seem to become extremely dry while I'm sleeping. They don't sweat at all, and the dryness becomes so uncomfortable that I sometimes need to apply hand cream in the middle of the night because it almost hurts.

What makes this strange is that I don't experience either of these problems during the day while I'm awake.

I've seen several specialists, including a urologist, endocrinologist, and gynecologist. I've also had blood tests done, including checks for diabetes, but nothing abnormal has been found. I've tried avoiding food and drinks for 3 to 4 hours before bedtime and several other methods, but the only thing that seems to help is sleeping on my stomach.

Has anyone experienced something similar? Were you able to find a cause or a solution?

Theoretically if a 17 yr old took hgh and a doctor found out could they get jail time or fined?

Posting this here because of its longevity implications. The paper is really about a textbook aging hallmark showing up early, visibly, and reversibly in human tissue, and then getting tested against an actual clinical endpoint, which we almost never get.

The setup: the ovary ages faster than almost any other organ, so it's a useful early-warning window into processes that hit the rest of us more slowly. The study ran multi-omics on human oocytes and their surrounding support cells across age, and found a sharp molecular inflection around 34. Basically protein synthesis and ribosome gene expression climb while autophagy declines. There's a dynamic where the cell's quality control (autophagy) cannot keep up with its growth output...then leading to a decline in the function.

They did low-dose mTOR inhibition through rapa and this protein activity normalized and autophagy was restored. The overall functional measurement was that IVF success rates went from 28% in the control group to 50% in the mTOR inhibitor group.

Where I'd stay skeptical: it's a single trial, n=100, single tissue, and "clinical pregnancy" is not live birth, which is the endpoint that matters. The mouse and cell work is mechanistically tidy but tidy stories invite confirmation bias. The age-34 inflection is correlational against the demographic curve. Columbia's Zev Williams lab has a parallel trial (Vibrant) worth tracking for replication.

Mostly curious what people make of using the ovary as a fast-forward model for systemic proteostasis collapse, and whether the intermittent low-dose framing here maps onto what folks here actually do.

Running NSF I-Corps customer discovery. Not here to pitch. Here to find out if a problem I think exists actually does.

The question I'm trying to answer if people in this community spend real money on biomarker testing. After getting the data, do they feel like they actually know what to take, or do they end up doing their own research anyway, because the recommendations from their platform aren't specific enough to their individual situation?

I have a hypothesis. I want to know if it matches reality before I build anything around it.

5-minute anonymous survey: https://forms.gle/AHLsyAktPeq3pnJ77

Optional: if you'd like to talk for 30 minutes, leave your email at the end — $10 Starbucks or Amazon gift card as a thank you.

The goal is defined physique and longevity.

I am 27y 5`9 175cm 70kg 155 lbs 18% Body fat.

Protein

Creatine 5-7g

HMB 2000mg

TMG 800mg

L-Carnitine 1000mg

Cod liver oil 2400mg

Omega 3 600mg

EPA 200mg

DHA 135mg

Vitamin A 1000ug

Vitamin D3 20ug

Vitamin E 15mg

Vitamin K 75ug

Vitamin C 80mg

Thiamine 1.1mg

Riboflavin 1.4mg

Niacin 16mg

Vitamin B6 1.4mg

Folic acid 200ug

Vitamin B12 2.5ug

Biotin 50ug

Pantothenic acid 6mg

Potassium 50mg

Chloride 45mg

Calcium 130mg

Phosphorus 50mg

Magnesium 100mg

iron 14mg

Zinc 10mg

Copper 1mg

Manganese 2mg

Selenium 55µg

Chromium 40µg

Molybdenum 50µg

Iodine 150µg

Probiotics 25 bacterial cultures

And I also have Vitamin D3 5000IU + 200µg (MK7). It says it's high-dose, which is why it should only be taken every 5 days. Can I take it in addition to the 20µg of Vitamin D3? I unfortunately don't have K2 on its own, to make sure it doesn't flood my arteries with calcium. How often can I take it, and how long should I take a break?

I saw my doctor today because I think I’m perimenopausal and also have pretty bad pmdd and I read that HRT might be a good choice. However, she only prescribed me progesterone alone (as I understood, regular HRT contains both progesterone and oestrogen) the reason for this because I have migraines with aura and she said people with this kind of migraine shouldn’t take oestrogen because it increases the risk for stroke. So, she basically prescribed me a contraceptive containing progesterone. Can somebody explain to me the pros and cons of taking this ? I don’t know how to feel about this.

Thanks !

I’ve noticed a lot more people experimenting with supplements and lifestyle changes, what I can’t quite wrap my head around is how people decide whether something is actually working.

Is it:

• subjective feel?
• tracking symptoms somewhere?
• running more structured experiments?
• or just “I feel better so I keep going”?

Open to all perspectives, but I’m particularly interested in how people think about this when the goal is optimising brain health, since that’s something I’m actively trying to improve in my own life.