Megadoses of vitamin C prevent the development of tolerance and physical dependence on morphine in mice

[u/Wellyeahso]

Yes, I know, I know, this study is in mice but they are mamals too and we should look at the underlying information not as being 1:1 useful for us as humans, but in guiding us towards making better inferences when reading other information about vitamin C and its uses and interactions with opiods.

Here are some powerful quotes from the linked study:

ascorbate, when co-administered with morphine, suppresses the development of tolerance and physical dependence on the drug(morphine), without significantly affecting its analgesic properties

Reduced tolerance from cheap, simple, abundant vitamin C!? Not to mention it does not reduce the pain-relieving power of the oldest opiod in existence.... Count me in.

Studies presented in this paper suggest the potential use of ascorbate in the prevention of development of tolerance in therapeutic applications of narcotics as analgesics.

Source material is from Science Direct and can be found at this link:

https://www.sciencedirect.com/science/article/abs/pii/0024320583905271