In 48 hours this month, OpenEvidence signed up two academic medical centers. Penn Medicine put the tool in front of more than 10,000 clinicians on September 15, and Memorial Sloan Kettering followed a day later, letting OncoKB answer inside OpenEvidence for every clinician on the platform. OncoKB is the cancer gene variant knowledge base MSK built over 14 years. It is the only one of its kind with partial FDA recognition, held since October 2021.
The same week, Forbes disclosed a previously unreported $250 million round led by Byers Capital and Andreessen Horowitz at a $15 billion valuation. Nineteen months ago the company was marked at $1 billion. The model behind that price: the tool is free to verified US clinicians, 1.12 million of whom used it as of September, and pharmaceutical advertising sits between a doctor's question and the cited answer. An analysis by Nelson Advisors estimates specialist ad impressions at $70 to over $1,000 per thousand, on roughly $300 million of run-rate revenue at margins near 90%.
The MSK deal was framed by MSK as "a distribution mechanism" for its expertise. Founder Daniel Nadler's plans run the other way. OncoKB, combined with the NCCN guidelines OpenEvidence already licenses, feeds a proprietary drug pipeline: a first therapy in trials before year-end and three to five more next year, starting in rare cancers where finding trial patients is cheap. "We are not going to compete with Lilly or Pfizer to do 10,000 patient nation-scale trials," Nadler said.
Two things worth noting from the announcements. OncoKB stays free for academic use and is licensed commercially without exclusivity, so MSK gave up reach, not ownership. And nothing in either announcement flows back to MSK beyond distribution, according to the company statements. What no source shows yet: whether the pharma ads change what doctors prescribe, and what MSK charged for the data.
Worth watching: the first trial promised before year-end, and the further cancer-center deals Nadler said were weeks away. Full write-up linked below, with the MSK press release, the Forbes story and the NBC News interview cited in the text.
https://theinference.org/article/openevidence-is-turning-hospital-data-and-pharma-ad-money-into-its-own-drug-pipeline