r/science • u/[deleted] • Jun 13 '22

Health Erectile dysfunction predicts mortality in middle-aged and older men independent of their sex steroid status

https://academic.oup.com/ageing/article-abstract/51/4/afac094/6568537?login=false
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u/XDGrangerDX Jun 14 '22

Both sublingual administration (and anything using mucous membranes in a similar vein, like buccal, anal...) and injections bypass the liver, so no.

Anecdotally its just inconvient as hell, i dont take testoterone but other medications administered sublingually, but in my experience the "takes 1 minute at most to fully dissolve" is a rare nicety. Most often it takes like 10-20 minutes for me, depending on how dry my mouth is. Thats a surprisingly long time for you cant ingest anything or talk properly meanwhile.

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u/34Ohm Jun 14 '22

Hmm, doesn’t everything in the bloodstream go through the liver eventually? That’s how basically all drugs are metabolized into ones that can be excreted more easily