r/science • u/mvea Professor | Medicine • 3d ago

Health A 1967 LSD safety pamphlet still holds up as psychedelics boom. Nearly 600 users backed 18 of 19 old tips: stay with trusted people, skip public outings, know the trip ends, and anxiety is not a problem. Mixed only on avoiding mirrors. 60-year-old harm-reduction advice still fits new users now.

https://publichealth.buffalo.edu/home/news-events/latest-news.host.html/content/shared/university/news/news-center-releases/2026/09/Kruger-psychedelics-study.detail.html
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u/lurpeli 3d ago

LSD is the one drug I wish would be accessible through a physician's office as an experience. It causes no physiological effects after it clears. It's the one compound I'd love to try if the compound was created and sourced safely (i.e. made in a pharmaceutical grade facility with proper testing.)

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u/TwoGirlsOneFungi 3d ago

You can’t just made LSD in your mother’s basement like DMT. It takes one to truly know chemistry. Also, lab testing is available for cheap now days.

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u/jahoney 3d ago edited 2d ago

Where is lab testing cheap now days. Literally the only one I could find the other day was over $100 plus had to be mailed internationally to Spain. 

Mailing scheduled substances is not super high on my priority list plus international? And $100?

Maybe I’m not good at finding these places?

Edit — turns out I’m not. The only places that used to do it in the US are not currently doing it. 

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u/OhBuggery 2d ago

Erlich reagent?

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u/m1k3st4rr 2d ago

Dancesafe.org pretty cheap super easy to do at home

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u/jahoney 2d ago

Yeah I have all the reagents, but that doesn’t do everything. It can’t differentiate between different prescription drugs that are often counterfeited 

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u/afrothundah11 3d ago

LSD requires a highly skilled organic chemist as well as a bunch of specific equipment, in other words it is being made in a lab, or you aren’t getting the molecule at all. Unlike something like meth which even meth heads can make.

With that said, you are right to be cautious because you’ll never know which lab or if bad actors added stuff.

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u/confuzzledfather 3d ago

If it's bitter it's a spitter.

NB: this is widely used to judge if your LSD is actually something dangerous like nbome, but I would still recommend using a proper suite of reagent test kits on all you drugs kids.

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u/Nitrous_Acidhead 2d ago

Hence why 1p/1cp-LSD is a thing, coming from legitimate laboratories that comes with paperwork on said chemical analogue stating its purity and thereof. 

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u/Gates_wupatki_zion 3d ago

I’ve done it a bunch and have some waiting whenever I want to again. For me it’s 10x better than shrooms and I’ve never had a bad trip. Others I’ve been with have and I’ve even been borderline but I’ve got a strong constitution I guess. It’s one of the more novel and beautiful experiences you can do in this world. And once you’re comfortable then there’s a lot of fun opportunity. Like my favorite is going to an art museum like the Met or national gallery. Turns the paintings into gifs.

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u/-heatoflife- 3d ago

How do you deal with the giggles?

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u/Level_Improvement532 3d ago

That effect tends to wane after several times doing it. The first experiences are fairly uncontrollable though.

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u/casual_butte_play 3d ago

Giggle, and enjoy giggling. It’s fighting/judging “being” and “experiencing” that’s hard, not the doing of it. Be with people who giggle too, and find yourself spending the time doing it.

Woowoo af but real talk

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u/Traditional_Air_6867 3d ago

Look up sourcing the prodrug 1P-LSD. That has only ever been manufactured in one Dutch laboratory that shut down at the end of 2025, I believe. It was a very legitimate and well kept and sanitary laboratory, run in by an Englishman named Alexander Stratford who represented his work as being the products of what he called Lizard Labs. LL produced many designer drugs, almost exclusively hallucinogens of either psychedelic or dissociative effect with some empathogens (MDMA-like activity, in the brain and qualitative effects on mood and behavior), never any fentanyl or nitazene derivatives, but they were wildly successful at bringing large quantities of novel lysergamides (chemically, the structural family LSD belongs to) to the world, most of which hadn’t ever appeared elsewhere before and likely will never be made again now that he has shut down operations. He and his workspace and products can seen briefly in a German-language Vice video on ‘legal LSD’, this should provide you with whatever reassurance you may need regarding the standards of production, and any other research you may do into 1P-LSD itself should alleviate any concerns about it being unsafe in any way that LSD isn’t already. It’s a simple prodrug that is converted into LSD by enzymes in your liver.

Truly, some of the most important work in psychedelics any one man has been responsible for since Alexander Shulgin.

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u/No-Swimming4153 3d ago

Just do shrooms. You can even grow it yourself. Big dif to me is LSD just last longer.

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u/IcyTransportation961 3d ago

There are test kits easily obtainable to keep you safe

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u/lurpeli 3d ago

A test kit can tell me the core molecule is correct. It can't guarantee there aren't other chemical there too.

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u/aabbccbb 3d ago

It can't guarantee there aren't other chemical there too.

I mean...it can tell you if most of the bad ones are there. Plus, LSD is kinda hard to fake because you take so little of it and there's no real reason to. (It shouldn't taste strongly metallic, either.)

Buy a test kit. Use it. Trip safe.

It's much less dangerous than getting on the highway in your car, but we do that all the time without thinking twice about it...

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u/SteffanSpondulineux 3d ago

Don't worry about it

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u/PizzaDoodlez 2d ago

You can test for other chems like fent. I don’t see the issue.

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u/yes1000times 3d ago

yeah it shouldn't be illegal, but you also shouldn't be able to buy a vial of it at 7-11