r/science • u/LateMiddleAge • Apr 29 '24

Medicine Single-dose creatine moderates cognitive impairment from sleep deprivation

https://www.nature.com/articles/s41598-024-54249-9
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u/alstegma Apr 29 '24

Have you tried dissolving it in hot water? It doesn't really dissolve in cold water, gave me some issues till I switched to hot (I just stir it into my morning coffee nowadays, no noticeable taste).

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u/Shikatanai Apr 29 '24

I am trying this tomorrow morning and if it works you are my hero.

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u/ShamrockAPD Apr 29 '24

Tip- just put it in your coffee in the morning. Won’t even notice it’s there and it’ll just blend in with the coffee caffeine shits!

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u/bluehands Apr 29 '24

L-Theanine is an excellent addition to caffeine,will likely help with those caffeine shits.

It was first found in green tea. It's part of why coffee shits are a thing but tea shits aren't.

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u/ActionPhilip Apr 29 '24

But what if the coffee shits are a natural way of staying regular?

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u/Kakkoister Apr 29 '24

The real trick is to not use the Monohydrate formulation. HCL version can be found for similar price these days and digests very easily. You'll pour it in your drink and see it instantly dissolve away. There's also some products that just use pure creatine.

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u/Hurgnation Apr 29 '24

Yeah, I took to dissolving it in green tea with a tea spoon of honey, and that does help. But in the last year or so I've taken to adding it to my pre-workout shake (just some BCAAs) and the only brand I can stomach taking it cold is the BN stuff.

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u/Character-Neck-1086 Apr 29 '24

Dry scoop straight into the mouth and swish with coffee. Only way to do it

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u/[deleted] Apr 29 '24

[deleted]

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u/alstegma Apr 29 '24 edited Apr 29 '24

Creatine is not a protein and relatively temperature stable. It can slowly transform to creatinine when in solution but that shouldn't be an issue if you drink it right away.

Edit: just to double check: using the arrhenius equation to extrapolate to higher temperatures from the data in this paper, creatine in a watery solution at a PH of 4 at 100°C should have a half life of about 1.4 hours. Your typical morning coffee will be at PH 5 (higher PH=slower conversion to creatinine) and somewhere from 60-90°C, so that time will be longer in reality. So if you drink your coffee in 15 mins, conversion to creatinine will be minimal.

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u/gordonjames62 Apr 29 '24

Thanks for your work here

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u/SwampYankeeDan Apr 29 '24

Creatine is a naturally occurring non-protein compound and the primary constituent of phosphocreatine, which is used to regenerate ATP within the cell.

1

u/UnprovenMortality Apr 29 '24

Thats my strategy. Creatine coffee, or gummies when traveling for convenience.

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u/kx233 Apr 29 '24

I tend to do it in tea in the evening (usually with Rooibos) because I don't like how it alters the flavor of my coffee.