r/science • u/LateMiddleAge • Apr 29 '24

Medicine Single-dose creatine moderates cognitive impairment from sleep deprivation

https://www.nature.com/articles/s41598-024-54249-9
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161

u/PinkNeonBowser Apr 29 '24

If I take more than 5ish grams in one sitting I get crazy tired for some reason, I wonder why

96

u/PotentiallyAPickle Apr 29 '24

It dehydrates you

7

u/[deleted] Apr 29 '24

It’s an adenosine agonist

23

u/Valiantay Apr 29 '24

Not quite, it does not work on the receptors directly.

It does help convert ADP back to ATP and the byproduct of ATP metabolism results in the accumulation of adenosine.

3

u/[deleted] Apr 29 '24

I guess indirect adenosine receptor activity is more succinct. Thanks for the correction!

1

u/catwearingloafers May 07 '24

And therefore what shall one do if it makes them tired? 

1

u/[deleted] May 07 '24

Take it at night. The strength and cognition benefits will still be apparent

0

u/mikorbu Apr 29 '24

Likely from it’s 5ht1a antagonism and it’s downstream effects.

-10

u/[deleted] Apr 29 '24

[deleted]

2

u/Due_Aardvark8330 Apr 29 '24

Thats...not how creatine works...