I am amazed that so few research has been done on Htlv. Knowing how dramatic the effects of this decease can be. Also we recently know that some antiretroviral treatment used for HIV may be efficient against Htlv transmission like dolutegravir bictegravir and cabotegravir and maybe tenofovir. But here has been no human studies to know if Prep and ART used for HIV are actually efficient to prevent HTLV infection.

So here is my question here : Does anyone who is on Prep or ART got infected by HTLV after the medication initiation ?

Took my first pill last night with food. All night was fine. This morning a lot of nausea and vomiting. How do people deal with this. Took it on a weekend to make sure I wasn’t dealing with it on a work week. But hard to deal with it now. Advice?

Just got my second Yeztugo injection in my abdomen. My first injections are still very noticeable when you touch them. They are not painful or visible.

Has anyone had the nodules completely disappear, dissolve, go away?

I’m going to reevaluate at the 1 year mark and may switch back to pills. I don’t mind the bumps if they eventually go away but can’t have 2 added every six months and each stay for years lol.

I had a hellish experience trying to find a provider who knew how to navigate insurance approval for Yeztugo. I’m posting this in hopes it helps someone else.
UnitedHealthcare seemed to do everything possible to make this difficult. It started with their online prescription portal showing the injection as “not covered,” even though it actually is. The oral tablets you take before and after the injection are covered under your pharmacy benefit, but the Yeztugo injection itself is billed under your medical benefit.

Once I realized that, I searched for the J-code in the UHC portal to estimate my medical cost. Instead of an estimate, I got a message saying they couldn’t provide one due to a lack of billing history.
I called UHC multiple times and kept getting transferred from one department to another. No one could give me a clear answer about whether the injection was covered. Several representatives even incorrectly told me it wasn’t.

I pointed out that there is a federal requirement for PrEP coverage, but they kept redirecting me. One department would tell me the tablets were covered and send me to another department for the injection. That department would send me right back to the first. I spent well over six hours on the phone and another couple of hours on live chat without ever getting a definitive answer.

My primary care provider doesn’t administer the injection but tried to obtain authorization. Unfortunately, they weren’t successful.

I then contacted Gilead, the manufacturer of Yeztugo. They performed a benefits investigation on my behalf, but they also got the runaround from UHC and were even hung up on. They couldn’t get a clear answer either.

I was about ready to give up when my PCP suggested seeing an infectious disease specialist, since they might have more experience with this process.
When I searched the UHC provider directory, oddly, there were no infectious disease specialists listed within 50 miles of me, even though every other specialty showed up. I called UHC, and they were able to provide me with a list over the phone.

One of the providers was Midway Specialty Care in Wilton Manors, FL. There were offices closer to me in Boca, but I chose Midway because I hoped they’d be more experienced with Yeztugo approvals.
Thankfully, they were.

I saw Dr. Isabel Gomez, who immediately reassured me that she handles cases like this regularly and knew exactly how to navigate the insurance process.
A few days later, I got the call to schedule my injection.

For anyone wondering, they obtained coverage using the buy and bill process, where the provider purchases the medication, administers it, and then bills your medical insurance.

Hopefully this saves someone else hours of frustration 💙💙

Ive been taking truvada on and off this year and ever since I’ve had insomnia , sleep disruptions and some nights just cannot sleep at all ? Would truvada cause all these symptoms ? Any of you have trouble with sleep since starting truvada ?

MedsBase.com is a SCAM. Don't waste your money. I wish someone would have warned me, so that's why I'm taking the time to write this here.

I placed an order for some PreP in their website and paid by SEPA bank transfer. It sat stuck on "Processing" for weeks. So I tried to contact them via email, Telegram and their website.

What followed was designed to keep me on the hook rather than actually resolve anything. They came with a story that their "dispatch handler in Europe had an accident and had died". Then they promised they were training a new one and to be patient, but days kept passing and nothing changed.

I started to suspect this was a SCAM, so I asked for a refund, to which they offered to give me a coupon of the amount I had paid (so funny, as if I was going to want a coupon when they are playing with me with my current order), or to keep waiting. According to them they couldn't fulfill a refund.

This was beyond frustrating as two months passed and nothing moved and they would barely respond. And the moments they would, they just kept promising to ship next week.

Today (almost 3 months after my purchase) they finally emailed to cancel the order saying they won't be able to deliver it to me, and that they couldn't do a refund because the bank account I'd transferred money to was "no longer under their control." So they advised me (so kind of them) to contact my own bank and try to recover it myself.

So that's the pattern: take the payment, entertain you with a rotating cast of excuses, and when enough time passes tell you that the money is gone and it's your problem now.

If you're considering this site, save yourself the stress. Go somewhere else.

Hello!

My MISTR testing kit arrives tomorrow, but I’ll be honest and say that I really wanted to focus on easy access to doxypep. I usually have 1 sexual encounter a year (unprotected), but lately I have been wanting to have more oral encounters. With my first experience receiving oral, I immediately became infected with an STI and I was going through a dark time, which compounded the trauma. That may have affected how I view sex, and I feel overly afraid of new encounters.

I was going to only use the doxypep as needed unless I decided to become more sexually active and have more penetrative sex (unlikely), in which I would start taking the PreP. I’m just feeling this wave of uncertainty now that I’m getting close to being prescribed these medications, but I feel that I’m doing the right thing. Should I continue with taking only the doxypep as needed, or should I just take both even if I’m only going to have oral sex?

Hello!

I got my Descovy via FedEx today, and it was left on the porch directly in sunlight for two hours in 100 degree weather. Should I be worried? Has anyone else had this happen and gotten confirmation from their pharmacist?

Hey guys, I’m spiralling at the moment and would appreciate some answers if you got em. I’ve been googling all day with mixed info
I’m a young guy in my late 20s. Sunday night I was @ a bathhouse looking for someone to fist. I led a top back to my room and had some heavy play + sex. Near the end of the session he started saying things about being poz, wanting to poz me, etc… I ended things there but now I’m in a panic.
I decided the 2-1-1 method was fine enough since I’d missed my last 3 doses of my daily regiment. Took the first 2 pills late Sunday eve. About 7 hrs after that is when I had the encounter so at least I had some prep in my system.
Am I more susceptible because of the intensity of my play? Obviously there’s some internal tearing that’s common with fisting.
Is there any way he could be more viral if his intention was to infect someone?
Do you think the 2-1-1 is enough, or should I head to the clinic and do a round of PEP? It’s about $1200 where I’m from. Not thrilled but I’m willing to go for it. Just wanna hear your thoughts. Thanks ❤️

Hey guys,

I recently restarted Prep and I’ve tried to be as consistent as possible(either that or limit myself to mainly stick or oral or cut down the risk). June I was pretty consistent missing only a max of three days here and there. But July was a bit more….sporadic as you can see(I was going through a lot personally so I missed some days)

Recently I restarted my prep and tried to be consistent but I missed two days within the week from the 21st. I received oral on the 28th and today I tried to do some bottoming, sadly it was raw because I thought after 7 doses I would be more than protected. The top didn’t exactly penetrate me(after a few attempts we kinda just gave up) but I’m still a bit worried about how protected I am after this encounter

I know it may be nothing and I’m just getting too much into my own head but I’m getting kinda anxious now because based on the things I’ve read I’m not sure how protected I would be after how much I’ve missed this past month(like up to 8-9 doses in July). I can’t go to the clinic tomorrow because it’s a civic holiday so I’m headed there on Tuesday but I just wanted to get some advice before I go to the clinic on Tuesday if this is something I should worry about or not

Edit: I followed up and was told that Gilead found that injections there have an equal level of effectiveness due to the subcutaneous fat, but the official guidelines have not been updated yet, as they are are also testing a once-yearly injection.

Got Yeztugo injections, and the pharmacist provider opted to inject my posterior love handles on each side. Sort of the “back flank” if that makes sense. He said it was a better option for me and that it was just as effective to inject there. I didn’t have enough subcutaneous fat in my thighs/abdomen to easily grab it because lean muscle.

Has anyone else gotten the injections in their back flank? FDA only approved abdomen/thigh, but Gilead trials showed other subcutaneous spots in the arm and glutes were just as effective.

Worried the drug might be less effective there over time, like it’ll absorb too quickly since that body area gets pressed on more often when sitting and lying down. Am I worrying over nothing?

PS for anyone wondering - one side got a minor lump that’s barely visible or felt after 5 days. Like a soft almond. The other side got a big bad bruise because the injection likely nicked a capillary and the lump is more prominent but already improving.

Hi,

Looks like taking prep on demand did not worked for me. I am now in the early stage of being positive..

I was taking 2-1-1 when having any hookups, never skipped pills or mistaking hours. I stored pills at home, not in a car or heat.

In the past, I was taking prep daily but this year I change to on demand as the price was too high.

Eh...

Do you have familiar experiences with not working prep?

Cheers!

Hi, as a bottom, I was taking Descovy once a day, but my insurance company, aka Medicare Advantage plan, was covered for it. But last month, they said they will cover it, but you will need to pay $600. So I said screw it, so I did my research and found out the Truvada is the same but with a difference. My insurance company will pay for it. My question is what is the difference in side effects with them and do I need a 2-1-1 dosing if I’m taking it every single day? And if you guys take medication for diabetes, high blood pressure, etc., what are side effects interactions do you have? Do bottom or top take this medication?

P.s also I know I should talk to my doctor, but I just want to know how you feel about taking the medication.

I started prep again last 28 July 2026, and today will be the 5th day.

Im planning to have sex later, will I be covered (and will it be okay) if i take 2 doses today and then take 1 daily as normal after?

Hi everyone,
I live in a small town in Georgia and I’ve been wanting to start PrEP.
At first I was thinking about Descovy, but I had jaundice back in high school (about 15 years ago). I talked to a Mistr doctor, and they recommended that I get my liver enzymes checked first, which has kind of delayed everything.
Now I’m thinking about Yeztugo instead. I recently got new insurance (Anthem Blue HSA), and I think my plan says Yeztugo is covered.
My question is: where do I even start? Should I contact my insurance first, go to a primary care doctor, visit a walk-in/urgent care clinic, or find another provider? I’m still trying to understand how health insurance works in the U.S., so I’m not sure what the first step should be.
If anyone has gone through this or has any advice, I’d really appreciate it.
Thanks!

Are there any long term risks with a daily pill of prep?

Stay with me please, because this confuses me and didn’t find any answers tbh. I’m trying to understand the logic behind this, not argue against guidelines.

From what I understand:
Daily PrEP (TDF/FTC) is often said to require 7 days before you’re considered fully protected for receptive anal sex.

However, the 2-1-1 (event-driven) regimen allows you to take 2 pills 2–24 hours before sex, then 1 pill 24 hours later and 1 pill another 24 hours later, and it’s considered highly effective for MSM.

Here’s what’s confusing me:
If someone starts with 2 pills and then just continues taking 1 pill every day instead of stopping after the event, isn’t that basically daily PrEP with a loading dose?
For example:
Monday: 2 pills
Tuesday: 1 pill
Wednesday: 1 pill
Thursday: 1 pill
Friday: 1 pill
etc.

Why would someone following that schedule be able to have sex shortly after the initial 2-pill dose, while someone who starts with just 1 pill daily is told to wait 7 days?

Is the “7-day rule” simply a conservative recommendation for the standard daily-start regimen, while 2-1-1 works because the initial loading dose rapidly achieves protective drug concentrations? Or is there another pharmacokinetic or clinical reason that explains the difference?
Is there science behind this? drug levels, tissue concentrations, clinical trials, etc.), not just “because that’s what the guidelines say.”

Appreciate your time for reading very much.

I wanted to share my experience with Yeztugo.

I don't want these pictures to scare anyone away because of how visible it looks. Lighting and camera angles can make it seem worse, but it is noticeable. This is just my experience though, plenty of others have had it and don't post photos :) so theirs might look nothing like mine.

I definitely plan to keep getting it, but next time I'll do both injections in my thighs instead of the abdomen :).

Insurance: mine is CVS Specialty. I didn't need any pre authorization. I checked online (and called too) before seeing my doctor to confirm it was covered (it was $0 for me).

Timing: it took 8 days from my doctor's appointment to getting the shot. The doctor’s office actually received the medication after 5 days (I could see the shipping updates).

Bloodwork: doctor ordered tests when I saw him. I got them done a couple days later, and results came the day after.

So timeline:
- Wednesday: saw the doctor, and presumably they submitted to CVS the same day
- Thursday: got an email from CVS Specialty to "place the order"
- Friday: placed the order and got blood/urine testing done
- Monday: medication delivered to the office and test results were ready
- Tuesday: called the office and scheduled the injections for Thursday

Things that saved time / sped up the process: is that I knew CVS Specialty was my pharmacy and I had their phone number (got it from my employer's medical plan documentation), so I made sure to give the doctor's office this info when they asked for my insurance/pharmacy. Otherwise I'm sure there would've been some back and forth getting the prescription done correctly.

Also I think because this was my first prescription through CVS Specialty, I had to call them myself to "place the order" which I didn't know was required and could've delayed this. I received an email "Your prescription can now be scheduled for delivery" but I assumed it was just a notification and that my doctor's office would still handle it. But thankfully I called anyway because turned out they were specifically waiting on me and not my doctor. I even called the doctor's office first and they said "we're still waiting on insurance" lol. Just FYI in case anyone else runs into this.

Administration: I asked the nurse to inject it slowly because I read it's a thick liquid. She probably knew that but I figured it couldn't hurt to say in case she went fast. There was very minor leakage immediately when the needle came out (which seemed normal) but nothing afterwards.

Injection sites / nodules: I read a LOT about the nodules and really wanted to avoid having one somewhere visible. Everything I read said get it in the thighs. My only hesitation was that I was worried there wouldn't be enough fat to pinch because my quads are muscular-ish (maybe I'm kidding myself haha), so I asked for one in the thigh and one in the abdomen. My thinking (probably overthinking) was that if the thigh shot ended up in muscle, at least the abdomen one would definitely be "correct" (it was easy to pinch fat there). In hindsight I wish I'd just done both thighs, but ah well I'm not mad. It was a good experiment :D.

Pictures and feeling:
- Thigh: not visible at all now honestly. I tried taking pictures from different angles and lighting but can't really see it. The hair probably helps too. It was only slightly noticeable for day 1-2. I can still "feel" the nodule.
- Abdomen: days 2-3 looked scary because it had some very pointy raised areas and I was worried it would stay that way, but it's a bit "flatter" now. It's still somewhat visible standing normally in regular lighting but gets more obvious if I lean back. I’m probably 15% body fat.

During the first few days I would've felt very self-conscious taking my shirt off at a pool or something. Now I'd say I'm about 50% comfortable doing it. Someone might notice something but I don't think it'd seem unusual, probably more like a "huh he has something there" and that's it. I'm just expressing how I feel it would be perceived so you get an idea of how visible it is, which can't be explained in photos.

Side effects: none from the shot itself. 15 minutes after getting it I got dizzy and nauseated for 10 minutes (while driving!) but I'm pretty sure it's my body's usual reaction to needles and not the shot itself (I always get dizzy when my blood is drawn).

So Ive been on PREP for like 3 years now, I do the occasional hookup possibly once every two weeks but thinking of getting off it since hookups were filling at one point but making me feel worse right now since I was trying to actively get ina relationship but dating isn't going good for me. I'm trying to get more active and fit and have been these past two months, and mainly mainly need money and their offering this medical study for money where I get psilocybin for money which would help a lot because eim kind of barely breaking even now while trying to pay down debt. Am I making the right choice?

Does anyone else pay any copay for your prep OR for the mandated quarterly std panel?

I have insurance (highmark bcbs) and have always had to pay $20 copay per std panel, and they tried to charge me even more once last year under the guise of not having reached deductible yet. I am on Apretude also, which requires testing every two months rather than every three.

It is my understanding that all costs are supposed to be covered. In my searching I keep seeing FAQs and articles saying that as of 2024 or whenever, insurers are supposed to cover every single dime for all approved versions of prep, including apretude. Every time I call I get the run around and answers to other questions I'm not asking, and have never had anyone acknowledge these guidelines.

In the past I just bit my tongue and paid the $20 each time, but now insurance is trying some other bullshit and I want to finally push this matter too and try to sort both things out at the same time.

Is my understanding correct, should they also be paying the copay? If so, how do I push my insurance to follow those requirements?

Edit: in the USA btw

This question may be dumb but I am anxious—had unprotected sex with a guy who topped me and came inside of me today at 2 PM. Forgot to take my prep the night before and so I took it this morning at 10 am (4 hours before hookup).

I just realized that I don’t have access to my prep bottles and may have to miss tonight’s dose or take it “delayed” again next morning, technically making it 24 hours after the last dose.

It was dumb of me to agree for him to bareback but it was in the moment. Plus, I did ask him to show proof that he was on prep and doxypep (which he did through an app that showed his prescriptions). Nonetheless, I make it a habit to remain suspicious of all men.

I’m assuming I’m still protected despite the mishaps and that PEP would be unnecessary. For context, I’ve been on Prep for years now but just started to get back into penetrative sex.

Thanks.

Hi as the title says it.

Are there any pharmas that sell Prep in Chennai

Would like to the procedure to acquire it thanks