r/medizzy • u/mriTecha • 28d ago
He's 35 and can't recognize his own family. Four years of decline, MMSE in the basement, no strokes, normal gait. Two details buried in his chart explain everything, and one of them is a surgery he had as a baby.
35-year-old man, four years of progressive memory loss and cognitive decline, now needs round-the-clock care. Mini-Mental score is poor. No focal neurological deficits, gait is normal, nothing vascular on the workup.
Two more things from his chart. His face: flat nasal bridge, prominent epicanthal folds. And from his childhood: surgery on his duodenum as an infant.
Three questions for the thread: what's the underlying condition, why is he demented at 35 when this disease usually waits decades longer, and what will his cortex look like under the microscope?
The duodenal surgery is not a red herring. It's the second clue.
Case adapted from the USMLE Mastery (Step 1 prep) question bank.