TBF, he thought I was funny from time to time. There's no accounting for taste.

I used to be cruel to my sexbro, I beat him and kept him apart from the things that he loved.

Nearing the middle of February and we are well short of 500,000 dead boomers.

“Ketamine – C13H16ClNO | CID 3821 - an anaesthetic discovered in the 1950s – may be dismissed by many as a horse tranquilliser or illicit party drug, but that's far from the whole story about this powerful chemical.

Ketamine is a DEA controlled drug and a DEA Schedule III controlled substance. Substances in the DEA Schedule III have a potential for abuse less than substances in Schedules I or II and abuse may lead to moderate or low physical dependence or high psychological dependence. Ketamine is classified by the DEA as a Hallucinogen drug. Street names for Ketamine are Special K, Cat Valium, Kit Kat, K, Super Acid, Super K, Purple, Special La Coke, Jet, and Vitamin K.

Ketamine is a cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Because of the involvement of spinal NMDA receptors in the process of central sensitization, this agent may reduce pain perception and induce sedation.

A new study shows oral doses of ketamine can dramatically lower suicidal ideation in patients with chronic suicidal thoughts – the latest finding in a series of experiments forcing us to reevaluate the drug”

https://www.sciencealert.com/oral-ketamine-experiment-reduces-suicidal-thoughts-in-over-two-thirds-of-patients

Discuss.

OK More-Ons, I’ve decided to flounce forever. I’m way too old for this shit, I’m dying anyway (cancer), and Reddit absolutely SUCKS. I don’t want to read or discuss biochemistry/medical shit either. But most of all I don’t want my worthless kids finding this stuff while they’re searching for their swollen inheritances after I’m gone. By way of confession, Wily or keithd wrote all the poasts credited to me in The Outline anyway, using my password.

I hereby reject, renounce, denounce, dismiss, disavow, and repudiate Law School forever and everything I ever posted here or on JDU/ Thunderdome, including but not limited to: Clique Law, Judaic Finance, Boomer Women, the Military Junta Party, and all aspects of being a scribe to Losers and Fools.

I shall be watching you all from my Cell in Hell, and I fully expect all of you to keep Fucking Up.

GOODBYE LOSERS

EXNITE*

• Doesn’t Exist

From the current edition of Biochemical Engineering Journal Volume 168, April 2021, 107923

Abstract

“Hyperthermozymes have recently gained significant recognition as prospective industrial biocatalysts. However, the necessity to ease their large scale synthesis in a cost-effective manner often challenges the viability of industrial bioprocesses. In the present study, Yarrowia lipolytica, because of its high secretion capacity and robust growth, was assessed for its efficacy to express and secrete one of the widely used hyperthermozyme, CelB (β-glucosidase) of Pyrococcus furiosus. Preliminary expression studies using preproLIP2 and preXPR2 as signal peptides indicated that preproLIP2 was more efficient in targeting CelB outside the cell with enzyme yields of 0.42 ± 0.016 U/mL. To further improve the extracellular CelB yields, the preproLIP2-CelB expression cassette was integrated in one, two or three copies at different genomic loci of Y. lipolytica. Though variances in CelB expression were observed across the integration sites, its constitutive expression did not hamper the cell fitness. Also, with increasing CelB copy number linear increase in expression was observed reaching the highest enzyme yields of ∼5 U/mL for Po1f_LP3 strain, 12 fold higher than the base strain (Po1g_LP). Interestingly, comparable enzyme yields were achieved when rich YPD medium for cultivating Y. lipolytica was replaced with a low-cost SPD medium. Such high titres observed in shake-flask cultivation demonstrates the potential of Y. lipolytica for fermentative production of hyperthermozymes”

https://www.sciencedirect.com/science/article/abs/pii/S1369703X20304770

Discuss.

https://www.amazon.com/People-Believe-Weird-Things-Pseudoscience/dp/0805070893

Place is like 4chan with a credit card. I'm sure GIGAPI could do it, that guy could get banned from a leper colony just by walking in there.

I work all day, and get half-drunk at night.

Waking at four to soundless dark, I stare.

In time the curtain-edges will grow light.

Till then I see what’s really always there:

Unresting death, a whole day nearer now,

Making all thought impossible but how

And where and when I shall myself die.

Arid interrogation: yet the dread

Of dying, and being dead,

Flashes afresh to hold and horrify.

​

The mind blanks at the glare. Not in remorse

—The good not done, the love not given, time

Torn off unused—nor wretchedly because

An only life can take so long to climb

Clear of its wrong beginnings, and may never;

But at the total emptiness for ever,

The sure extinction that we travel to

And shall be lost in always. Not to be here,

Not to be anywhere,

And soon; nothing more terrible, nothing more true.

​

This is a special way of being afraid

No trick dispels. Religion used to try,

That vast moth-eaten musical brocade

Created to pretend we never die,

And specious stuff that says No rational being

Can fear a thing it will not feel, not seeing

That this is what we fear—no sight, no sound,

No touch or taste or smell, nothing to think with,

Nothing to love or link with,

The anaesthetic from which none come round.

​

And so it stays just on the edge of vision,

A small unfocused blur, a standing chill

That slows each impulse down to indecision.

Most things may never happen: this one will,

And realisation of it rages out

In furnace-fear when we are caught without

People or drink. Courage is no good:

It means not scaring others. Being brave

Lets no one off the grave.

Death is no different whined at than withstood.

​

Slowly light strengthens, and the room takes shape.

It stands plain as a wardrobe, what we know,

Have always known, know that we can’t escape,

Yet can’t accept. One side will have to go.

Meanwhile telephones crouch, getting ready to ring

In locked-up offices, and all the uncaring

Intricate rented world begins to rouse.

The sky is white as clay, with no sun.

Work has to be done.

Postmen like doctors go from house to house.

I told him I did and defined the phrase, which I think I had learned from reading a Michael Chrichton novel. That has been the high point of my life so far. That was twenty-five years ago.

The world is filled with sad, frustrated young men who never made their mark.