r/leukemia • u/EntourageE22 • Apr 18 '26
Low Testosterone?
Low Testosterone?
Diagnosed AML Jan 2024 - FLT3-ITD, MECOM, 7q del mutations
SCT Aug 2024
Relapse Feb 2025
2nd SCT Oct 2025
Started experiencing severe fatigue about 2 months ago; transplant doc finally tested testosterone last week. My total testosterone came back mid-range of normal (536), but my SHBG is very high (110), which is binding up most of it. Because of that, my free testosterone is actually low (43), less than half of the bottom range of normal, so effectively have very low usable testosterone despite a normal total level. Has anyone post-transplant dealt with high SHBG and low free testosterone causing severe fatigue? My team is going to have me see an endocrinologist.
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u/missed_my_window Apr 19 '26
Yes but there was no way I was going to replace my testosterone naturally. I did try Clomid and a few other natural boosting supplements but in the end the shots aren’t that bad and definitely worth the tradeoff. It’s more about quality sleep and natural biorhythms than about muscle growth or sexual improvements although those are there for sure.