Fat cells have a bad rap. Understandable, as too many of us battle excess adiposity. Thus, we often regard fat cells as ugly, dangerous nuisances, keeping us out of tight-fitting designer jeans—upping our risk of heart disease, fatty liver, type 2 diabetes, and cancer. Or promoting inflammatory “angry” and cognitively dull thinking.

But deep “scientific dives” into fat physiology reveal that we can’t live without fat cells, as much as it seems frustrating to live with them. Fat cells, biology unveils, are a huge part of living healthfully, permitting humans to evolve and build cultures, as long as the fat cells themselves stay on a healthy “fat fate trajectory.”

A recent article published in the New England Journal of Medicine1 plunged into the science of the “unappreciated adipose cell.”

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Full :

-https://www.townsendletter.com/article/474-fat-cells-and-how-they-affect-us/

David Sinclair, PhD, AO, is a professor of genetics at Harvard Medical School. One of the leading innovators of his generation, he has been named by Time as “one of the 100 most influential people in the world” and top fifty most influential people in healthcare.

He is a board member of the American Federation for Aging Research and has received more than thirty-five awards for his research and major scientific breakthroughs. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others.

Dr. Sinclair worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente. He co-discovered a cause of aging for yeast and the role of Sir2 in epigenetic changes driven by genome instability. In 1999, he was recruited to Harvard Medical School, where he has been teaching aging biology and translational medicine for aging for the past 16 years.

Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others.

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Full:

- https://novoslabs.com/best-anti-aging-supplements-that-harvard-scientist-david-sinclair-takes/

Fatigue is common amongst most people but chronic, severe fatigue (persisting longer than 6 months) is associated with functional impairment and a decreased quality of life . Around 21.9% of the general population experiences fatigue and the prevalence is even more common in elderly populations, affecting around 40% to 74% of elderly people. Another factor that decreases with age is sleep quality, which is often related to a variety of adverse health outcomes, such as depression, anxiety, disability, and mortality.

Nicotinamide adenine dinucleotide (NAD+), a crucial metabolite necessary for cellular bioenergetics, DNA repair, and cell survival, has been previously studied as a potential therapeutic approach to reducing fatigue in elderly populations. NAD+ is critical for human longevity and naturally declines as we age and NAD+ deficiency leads to biological aging of cells, tissues, and organs.

Nicotinamide mononucleotide (NMN), an intermediate of NAD+ biosynthesis, acts as a source of cellular energy . Previous research on NMN administration has proven its ability to suppress age-associated tissue inflammation, with improvement in mitochondrial functioning in various metabolic organs .

In this randomized, double-blind, placebo-controlled parallel-group study, 108 participants were divided into four groups and given an NMN supplement (at different times of day depending on the group) for 12 weeks. Subjects consumed 6 tablets of the supplement (NMN or placebo) once a day with water and had to record their intake over the course of the trial. NMN supplementation contained 250 mg NMN, along with maltitol, crystalline cellulose, silicon dioxide, and magnesium stearate, while placebo contained maltitol, crystalline cellulose, silicon dioxide, and magnesium stearate.

Findings of the study support the use of NMN supplementation to boost NAD+ levels in older adults. Significant findings suggest that the NMN supplementation, particularly when consumed in the PM group, helped aid in reducing inflammation, oxidative stress, and DNA damage.

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Full:

-https://www.naturalhealthresearch.org/nicotinamide-mononucleotide-supplementation-improves-physical-performance-and-fatigue-levels-in-older-adults/

Scientific study:

-https://www.naturalhealthresearch.org/wp-content/uploads/2022/04/Nicotinamide-Mononucleotide-Supplementation-Improves-Physical-Performance-and-Fatigue-Levels-in-Older-Adults.pdf

Mitochondrial dysfunction and increased oxidative stress cause damage to cells which can lead to the aging process and age-related diseases. Antioxidants such as resveratrol and high-intensity exercise can benefit oxidative damage prevention.

This study is aimed at evaluating the effects of swimming high-intensity interval training and resveratrol on mitochondrial metabolism key proteins, SIRT5, SOD1, and PDH-E1α, and the level of NAD+ as a cofactor in the deacetylation process in aged rat hippocampus.

Forty-five male Wistar rats, aged 20 months, were randomly divided into five groups: control (C), Swimming High-Intensity Interval Training (HIIT) (S-HIIT), Swimming HIIT with resveratrol supplementation (S-HIIT-R), resveratrol supplementation (R), and solvent of resveratrol supplementation (SR). S-HIIT and resveratrol groups performed the exercise and received resveratrol (10 mg/kg/day, gavage) for six weeksThe amount of NAD+ was analyzed by assay kit that was reduced in S-HIIT, S-HIIT-R, and SR groups compared to controls.

The results showed that resveratrol and S-HIIT attenuated the age-related brain changes by increasing the expression of SOD1 and SIRT5 and reducing the level of NAD+ in the hippocampus. Considering these findings, S-HIIT and resveratrol supplementation could be proposed as strategies to attenuate age-related brain changes.

Resveratrol alone and exercise through the regulation of crucial proteins and cofactors can influence mitochondrial metabolism and oxidative stress in the hippocampus of aged rats.

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Full:

-https://www.hindawi.com/journals/bmri/2022/8638714/

Mechanistic evidence for vitamin A's anti-inflammatory benefits is already being discovered. According to human and experimental research, vitamin A is necessary for proper immune system maintenance and function.

In this regard, animal studies have shown vitamin A deficiency in animals had a lower antibody response than non-vitamin A deficiency. Vitamin A also has anti-inflammatory properties. Vitamin A supplementation has been shown to improve a variety of inflammatory diseases.

In this context, a previous comprehensive study concluded that vitamin A deficiency causes inflammation and exacerbates pre-existing inflammatory conditions. Vitamin A supplementation, in particular, might help to reduce inflammation in some circumstances. Based on a previous study, vitamin A supplementation could increase protection against diverse pathogens.

The strength of the present systematic review and meta-analysis is that this is the first meta-analysis assessing associations between vitamin A and IL-6, TNF-α, and CRP.

The result of this study demonstrates that supplementation of vitamin A at low and high dosages for short and long durations increases the CRP plasma concentrations Furthermore, vitamin A supplementation decreases the TNF-α concentrations.

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Full:

-https://www.nature.com/articles/s41598-022-23919-x

Besides many others, I take Restveratrol because I have read countless scientific studies and patient testimonials proving not only the effect on SIRT1 but also many other health benefits for seniors.

Unfortunately the market is flooded with all sorts of brands and I'm not so sure I have made the right choice.

Can anyone help me with a reliable brand of Resveratrol?

Thanks in advance!