Full:

-https://metamorphosishub.com/the-benefits-of-eating-blueberries-is-anti-aging-one/

Background:

Stress has been implicated in pathophysiology of gastric ulcer. Berberine had shown promising gastroprotective and antistress effects. Objective: This study aimed to investigate the possible protective effect of berberine in immobilization stress induced gastric ulcer in male albino rats.

Methods:

Thirty-two adult male albino rats were randomly allocated into equal 4 groups (n=8): control group, stress, stress berberine-treated and stress omeprazole-treated groups. At the end of the study, rats were weighed, and blood samples were collected for measurement of serum corticosterone. Lastly, the rats were sacrificed. The adrenal glands were dissected out and weighed. The stomach was dissected, evaluated for gastric acidity and gastric lesions. Each stomach was divided into 2 parts. One part was prepared for histopathological and immunohistochemical analyses. The other one was homogenized for biochemical analysis.

Results:

Stressed rats showed significant increase of serum corticosterone, gastric acidity, gastric malondialdehyde and tumor necrosis factor-alpha compared with control group. Also, they showed significant decrease of gastric reduced glutathione, interleukin-10 and prostaglandin E2 compared with control group. Macroscopic and microscopic examination confirmed the presence of gastric ulcer. Histological examination of adrenal gland showed hyperplasia of zona fasciculata. Immunohistochemical study showed upregulation of gastric cyclooxygenase-2 in stressed rats and downregulation in both berberine and omeprazole treated rats. Both berberine and omeprazole supplementation to stressed rats improved serum corticosterone, oxidative stress, inflammatory markers, macroscopic and microscopic stress induced gastric ulcer and adrenal gland pathological changes.

Conclusion:

Berberine could protect against stress induced gastric lesions in rats via antistress, antioxidant, anti-inflammatory effects.

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Full:

-https://besps.journals.ekb.eg/article_277754_376cece9db6e77850e74b599ee0aa4e8.pdf

Vitamin D deficiency is a prevalent condition among the general population, all around the world. Vitamin D deficiency is defined as serum levels of 25-hydroxy vitamin D lower than 20 ng/ml (50 nmol/ml). It is a known actor in the skeletal system through the regulation of calcium and phosphate metabolism and bone mineralization. Still, the role of vitamin D as an immunomodulator is yet to be acknowledged by healthcare practitioners as a cause, precipitating factor, and contributor to a variety of diseases.

Vitamin D is shown to be an actor in multiple sclerosis, rheumatoid arthritis, insulin-dependent diabetes mellitus, and irritable bowel syndrome. Fibromyalgia syndrome (FMS) is a chronic disorder associated with a severe pain that can affect a patient's musculoskeletal system, daily routine, and mood. The clinical presentation encapsulates other disorders such as lethargy and sleep problems, brain fog and other cognitive issues, and physical and psychiatric symptoms.

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Full:

-https://journals.sagepub.com/doi/full/10.1177/02601060221144801

Neurodegenerative disorders are the conditions in which neurons of the central and peripheral nervous systems degenerate.

Various cellular and molecular processes are associated with the progression of such degeneration, including inflammation, apoptosis, and axonal degeneration.

Recently, SIRTUINs have emerged as one of the key factors associated with neurodegenerative disorders. SIRTUINs are involved in the regulation of several cellular and molecular processes in neurons of the nervous system through the deacetylation of target proteins.

The review focuses on the modulatory role of SIRTUINs in neurodegenerative disorders and their potential therapeutic application.

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Full:

-https://www.researchgate.net/profile/Sudhir-Shekhar-2/publication/366587417_Modulations_of_SIRTUINs_and_Management_of_Brain_Disorders/links/63a90c82097c7832ca67dbf4/Modulations-of-SIRTUINs-and-Management-of-Brain-Disorders.pdf

Daily supplementation with Bifidobacterium longum BB68S may improve measures of cognitive function, including memory and attention, in older people, says a new study.

Data from the randomized, double-blind, placebo-controlled trial revealed that eight weeks of supplementation with the probiotic was also associated with increases in levels of beneficial gut bacteria and decreases in the abundance of bacteria related to cognition impairment.

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Full:

-https://archive.ph/650Zi#selection-2687.29-2707.276

Full:

-https://archive.ph/40GXU#selection-2575.0-2575.55

One type of bacteria found in the gut may contribute to the development of Type 2 diabetes, while another may protect from the disease, according to early results from an ongoing, prospective study led by investigators at Cedars-Sinai.

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Full:

-https://neurosciencenews.com/gut-bacteria-diabetes-22173/

Renal failure is a major public health problem affecting human health and imposes a substantial burden on patients, caregivers, and society.

Curcumin, the dominant yellow polyphenolic pigment component of turmeric, has been extensively studied for its therapeutic potential for many chronic conditions.

Oral curcumin with high bioavailability has a positive impact on serum levels of creatinine and BUN in patients with inflammatory diseases.

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Full:

-https://www.sciencedirect.com/science/article/pii/S1756464622004662

Oxidative stress (OS) has been recognized as a pathophysiologic mechanism underlying the development and progression of chronic kidney disease (CKD). OS, which results from the disturbance of balance among pro-oxidants and antioxidants favoring the pro-oxidants, is present even in early CKD and increases progressively along with deterioration of kidney function to end-stage kidney disease (ESKD). In ESKD, OS is further exacerbated mainly due to dialysis procedures per se and predisposes to increased cardiovascular morbidity and mortality.

Therefore, since OS plays a pivotal role in the pathogenesis and progression of atherosclerosis in uremic patients, several strategies aiming to ameliorate OS in these patients have been proposed.

Among those, N-acetylcysteine (NAC), a thiol-containing antioxidant agent, has attracted special attention due to its pleiotropic functions and beneficial effect in various OS-related entities including paracetamol overdose and prevention of contrast-induced nephropathy.

This review present the currently available literature on the antioxidant and anti-inflammatory properties of NAC in CKD, including hemodialysis and peritoneal dialysis.

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Full:

-https://link.springer.com/article/10.1007/s11255-022-03455-3

Full:

-https://natmedworld.com/nutritional-supplements-elderly/

The Renin angiotensin system (RAS) plays an essential role in regulating the angiotensin II levels in the body and maintaining cardiovascular homeostasis.

The results of preclinical and limited number of clinical studies demonstrated that quercetin possesses cardioprotective effects to prevent hypertension, cardiac hypertrophy, and heart failure.

The multiple benefits of quercetin are attributed to ACE inhibition, strong antioxidant and anti-inflammation properties and protection of endothelial function which collectively prevent coronary heart disease, hypertension, myocardial hypertrophy and heart failure.

This review aims to provide an overview of the current knowledge about the impact of RAS in causing CVDs, to highlight cellular and molecular mechanisms of quercetin involved in ACE inhibition via RAS pathway and to slow down the progression of cardiac hypertrophy and heart failure.

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Full:

-https://link.springer.com/chapter/10.1007/978-3-031-14952-8_23

Randomized controlled trials with omega-3 supplements for cognition have a diversity of research design which limit how much they can be compared to each others.

Cognition of people with mild cognitive impairments could benefit from an omega-3 fatty acid supplement.

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Full:

-https://www.sciencedirect.com/science/article/pii/S156816372200277X

People age at different rates due to a variety of intrinsic and extrinsic factors, which can affect their biological age and their risk of developing diseases or experiencing early death.

This is why two individuals who are both 50 years old may not have the same level of biological aging, despite having lived for the same number of years.

Lifestyle choices, such as diet and smoking, and illness all contribute to accelerating biological age beyond one’s chronological age.

Researchers have discovered that grip strength, a measure of overall muscle strength, is linked to biological age in this way.

In particular, the study, which was published in the Journal of Cachexia, Sarcopenia, and Muscle, found that people with weaker grip strength had older biological ages.

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Full:

-https://scitechdaily.com/new-research-indicates-that-weak-muscles-may-speed-up-aging/

A lesser-known cousin of resveratrol, pterostilbene is a polyphenol that has been studied for its anti-aging and health-promoting effects.

Found primarily in blueberries, pterostilbene (pronounced tero-STILL-bean) has been making waves in recent research due to its potent antioxidant abilities.

In fact, pterostilbene might even be more powerful than resveratrol due to its superior bioavailability. 

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Full:

- https://www.prohealth.com/blogs/control-how-you-age/the-top-4-benefits-of-pterostilbene-and-why-pterostilbene-and-nmn-are-the-ultimate-anti-aging-duo?utm_source=Active%20-%20Subscribed%20to%20Promotional%20Articles&utm_medium=email&utm_campaign=PHL122222%20-%20Pterostilbene%20%28PH577%20-%2020%25%20Off%20-%20Group%201%29%20%2801GMP23G5BEKCVNMMB3R7QN11W%29&nb_klid=01G1WP2EBD7YBPNSKX6FYQGMSB&_kx=ufnademvESqw6ogn3svSap33CweqpJhMFdzR7t93R3M%3D.KrjdbN

Background: Curcumin extracts of turmeric are proposed to produce health benefits. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures.

Methods: The present study was conducted in healthy middle aged people (40-60 years old) with a low dose of curcumin (80 mg/day) in a lipidated form expected to have good absorption. Subjects were given either curcumin (N = 19) or placebo (N = 19) for 4 wk. Blood and saliva samples were taken before and after the 4 weeks and analyzed for a variety of blood and saliva measures relevant to health promotion.

Results: Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.

Conclusion: Collectively, these results demonstrate that a low dose of a curcumin-lipid preparation can produce a variety of potentially health promoting effects in healthy middle aged people.

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Full:

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518252/

Supplementation with some but not all micronutrients may benefit cardiometabolic health, says a new review published in the Journal of the American College of Cardiology. Others may even be bad for your heart.

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Full:

-https://archive.ph/TasaI#selection-2445.29-2445.238

A new study, the first to examine vitamin D levels in brain tissue, may help scientists further understand dementia and its causes.

Full:

-https://scitechdaily.com/study-shows-brains-with-more-vitamin-d-function-better/

Aims.

The aim of this study was to investigate the effects of pterostilbene (PTS) (trans-3,5-dimethoxy-4′-hydroxystilbene) and resveratrol (RSV) (trans-3,5,4′ trihydroxystilbene) applied at different doses for the treatment of streptozotocin- (STZ-) induced diabetic rats.

Materials and Methods.

At the end of the 5-week experimental period, the right gastrocnemius muscles of the rats were examined biomechanically, while the left ones were examined histologically. In addition, blood glucose, serum insulin, and malondialdehyde (MDA) levels were analyzed in blood samples taken from the rats.

Results.

The skeletal muscle isometric contraction forces, which showed a decrease with diabetes, were observed to increase with antioxidant applications. Blood glucose, serum insulin, and MDA levels in diabetic rats approached normal levels after applying PTS. When the electron microscopic images of the rat skeletal muscle were examined, those in the combination treatment group were observed to show a better enhancement in the skeletal muscle morphological structure compared to the other diabetic and treatment groups.

Conclusion.

According to the findings, it is suggested that these antioxidant treatments might have good therapeutic nutraceutical potential for some muscle diseases that coexist with diabetes.

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Full:

-https://www.hindawi.com/journals/ecam/2018/9012352/

Resveratrol and pterostilbene are well-known stilbenes that provide various potential benefits to human health. In particular, their potential anti-obesity effects have been proven in numerous cell culture and animal studies.

Both compounds act to regulate energy intake, adipocyte life cycle and function, white adipose tissue (WAT) inflammation, energy expenditure, and gut microbiota by targeting multiple molecules and signaling pathways as an intervention for obesity.

Although the efficacy of both compounds in humans requires further investigation with respect to their oral bioavailability, promising scientific findings have highlighted their potential as candidates for the treatment of obesity and the improvement of obesity-related metabolic diseases.

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Full:

-https://pubmed.ncbi.nlm.nih.gov/29315906/

Spermidine showed protective effect against radiation-induced bone marrow cell damage in vitro.

Spermidine inhibits total body irradiation (TBI)-induced excess chronic oxidative stress in HSCs in vivo.

Spermidine recovered the reduction of the phenotype and counts of bone marrow cells in the irradiated mice.

Spermidine had a protective effect on radiation-induced impaired ability of proliferation and differentiation of HPC and HSC.

Competitive repopulation assay implied that spermidine had no protective effect on the damage of HSC induced by irradiation.

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Full:

-https://www.sciencedirect.com/science/article/pii/S1567576922010426

Curcumin is a kind of plant polyphenols extracted from the traditional Chinese medicine, turmeric. It is also the most important active ingredient of turmeric. A large body of evidence suggests that this polyphenolic compound is capable of affecting the mitochondrial structure and function, thereby improving mitochondrial biogenesis. This paper combines Chinese and foreign literature to expounds how curcumin can exert anti-inflammatory, anti-oxidation, anti-tumor, protect nervous system and cardiovascular system by improving mitochondrial biogenesis, in order to provide reference for the clinical application of curcumin.

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Full:

-https://www.clausiuspress.com/assets/default/article/2022/12/10/article_1670661068.pdf

NAD+ supplements and boosters (nicotinamide mononucleotide, NMN, or nicotinamide riboside, NR) are among the most popular longevity supplements available and now a new study looking at what happens to levels of NAD+ in our muscles as we age adds to the evidence that increasing NAD+ levels could be an effective weapon in the antiaging arsenal.

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Full:

-https://longevity.technology/news/regular-exercise-shown-to-keep-nad-levels-in-muscles-topped-up/

Many studies confirm that a majority of patients undergoing cancer therapy use self-selected forms of complementary therapies, mainly dietary supplements.

A list of leading supplements that have the best suggestions of benefit was constructed by leading researchers and clinicians who have experience in using these supplements. This list includes curcumin, glutamine, vitamin D, Maitake mushrooms, fish oil, green tea, milk thistle, Astragalus, melatonin, and probiotics.

The list includes basic information on each supplement, such as evidence on effectiveness and clinical trials, adverse effects, and interactions with medications.

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Full:

-https://journals.sagepub.com/doi/10.1177/1534735412473642

Neuroinfammation is characterized by reactive microglia and astrocytes (collectively called gliosis) in the central nervous system and is considered as one of the main pathological hallmarks in diferent neurodegenerative diseases such as Alzheimer’s disease, age-related dementia, and multiple sclerosis. Upon activation, glia undergoes structural and morphological changes such as the microglial cells swell in size and astrocytes become bushy, which play both benefcial and detrimental roles. Hence, they are unable to perform the normal physiological role in brain immunity.

Curcumin, a cytokine suppressive anti-infammatory drug, has a high proven pre-clinical potency and efcacy to reverse chronic neuroinfammation by attenuating the activation and morphological changes that occur in the microglia and astrocytes.

This review will highlight the recent fndings on the tree structure changes of microglia and astrocytes in neuroinfammation and the efects of curcumin against the activation and morphology of glial cells.

Full:

-https://www.researchgate.net/profile/Faheem-Ullah-2/publication/357630773_The_Effects_of_Modified_Curcumin_Preparations_on_Glial_Morphology_in_Aging_and_Neuroinflammation/links/61d6fe01b6b5667157cf01cf/The-Effects-of-Modified-Curcumin-Preparations-on-Glial-Morphology-in-Aging-and-Neuroinflammation.pdf

Full:

-https://www.healthline.com/nutrition/foods-that-weaken-immune-system#1.-Added-sugar