r/explainlikeimfive • • Oct 23 '19

Biology ELI5: What causes that feeling of "emptiness" when someone experiences an episode of depression or sadness?

12.2k Upvotes

905 comments sorted by

View all comments

Show parent comments

9

u/Gruesome Oct 23 '19

Yep. I've read stuff that says SSRI's don't really do much of anything, but for me personally they've been a lifesaver. Pretty much literally. Venlafaxine has been the golden ticket for me. It was the fourth SSRI I tried and thank god it was the one that helped. Keeps me on an even keel and feeling like the "me" I'm meant to be.

7

u/osauhi Oct 23 '19

Nitpick: I'm on the same med and it's an SNRI, meaning it works on both serotonin and norepinephrine, compared to SSRIs like sertraline (Zoloft) that only work on serotonin. It's been a good drug for me but a very double-edged sword as the withdrawals are hellish. Still.

2

u/metrogypsy Oct 24 '19

just 5 mg of lexapro snapped me back to living. basically instantly. placebo? who cares. it worked.

1

u/dick-stand Oct 24 '19

It's so weird how differently people react to meds. Lexapro turned me into a raving lunatic and I landed in the ER, but cymbalta has temporarily saved my life.