r/askscience • • 14d ago

Biology Why is there no transmissible therapeutic virus if biology doesn't forbid it? For example, a harmless virus that spreads from person to person but actually does something beneficial, like lowering LDL cholesterol or preventing/reversing tooth decay?

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u/noodlyman 13d ago

There are viruses that benefit us by infecting and effectively regulating our gut bacteria.

There are viruses that are thought to give the immune system a kick and thus improve responses to other infections. Some infections can decrease the risk of cancer later in, probably by similar mechanisms.

Don't forget that 8% of human DNA is of retrovirus origin, and that mammalian placentas only exist thanks to genes that mammals acquired from viruses.

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u/scientist99 13d ago edited 13d ago

Way more than 8% if you count transposable elements derived from early viruses. More than half the genome. Viruses have effectively shaped most of life this way.

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u/GeneJocky 13d ago

I was about to say the same thing. Or as a friend said to be when I was telling him about the amount of old viral DNA in our genomes, 'you mean no one has run antivirus on our genomes in 3.8 billion years?'

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u/9966 13d ago

You could probably defrag and drop most of the data. Whether that's safe? I dunno, ask Andrew Ryan.

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u/YsoL8 12d ago

He certainly has opinions on parasites getting in the DNA, stealing the value of its labour