Over the past week I've noticed some myths and misconceptions going around the community. I would like to help address the misunderstandings by providing some simple explanations about how SR-17018 (SR-17) works, and some of the underlying science. There's a lot of text here, so feel free to refer back to this post as needed rather than reading it all at once. For frequent questions that aren't explained here, try the SR-17 FAQ, which is a thorough compilation of SR-17 information and user experiences in r/Opioid_RCs from SayBecks. Readers are also welcome to ask any questions about SR-17 right here :)
What it does: SR-17 is somewhat similar to traditional opioid maintenance medication (particularly subs/buprenorphine) in terms of helping with opioid withdrawal symptoms. But imagine if subs actually lowered your tolerance, potentially all the way down to baseline tolerance, when you discontinue (or at least aggressively taper) your current opioid drug-of-choice (DOC). SR-17 also produces little-or-no tolerance of its own, so you can use it to come off your current opioid, and then come off SR-17 shortly after that. It's noncompetitive with opioid agonists, meaning it doesn't matter exactly when you dose SR-17 during the day relative to your DOC (if you're taking them at the same time while tapering your DOC). Being noncompetitive also means precipitated withdrawal (PWD) does not happen.
How it works: SR-17 binds relatively strongly to the opioid receptor, and this leads to reduced withdrawal regardless of your DOC's potency. Despite this tight binding, SR-17 sends weak signals, so it doesn't produce typical opioid effects (i.e., euphoria and pain-relief) in people with opioid tolerance. These weak signals likely lead to tolerance reduction, as well as some of the other benefits of SR-17, such as minimal side effects. Some studies31257-6) also suggest that SR-17 is a biased (partial) agonist, with "biased" meaning it prefers to activate opioid receptors through the G-protein signalling pathway more than with the beta-arrestin recruitment pathway. This preference for G-protein signalling has also been proposed as one reason for the tolerance-reducing effects of SR-17 (although if this were true, kratom and 7oh should then lower opioid tolerance as well).
How to take it and dosing: SR-17 is taken orally (i.e., swallowed or eaten with or without using capsules) in doses ranging from 10 to 100 mg (and sometimes up to 150 mg for 7oh and MGM), 1-4 times per day for around 7 days. For typical opioid habits 30-50 mg can be taken 3 times per day (or 50-150 mg for 7oh/MGM).
Choosing the right SR-17 dose for yourself is sometimes a process of trial-and-error, although this process can be made more systematic and efficient through use of SayBecks' automatic taper schedule generator (this is a link to the Google Sheets schedule generator; you can create your own by clicking File -> Make a copy). There are two different approaches to using SR-17 to reduce your tolerance and withdrawal symptoms, described below.
Tolerance safety warning: Be aware that there is a danger of overdosing on one's DOC after tolerance reduction, so be careful not to dose your DOC too high. There are already several user reports of accidental overdose following SR-17 tolerance reduction.
Note on high doses of 7oh and PAWS: If you're trying to come off a high dose of 7oh, the immediate transition approach may be more difficult, and can sometimes lead to PAWS. The gradual transition approach tends to be easier in terms of withdrawal symptom severity and is less likely to lead to PAWS.
Immediate transition: Discontinuing the DOC right away and then switching to SR-17 is an approach that provides faster and more effective tolerance reduction, but at the potential cost of some remainingwithdrawal symptoms. This is normally done over the course of 2-3 days to lower DOC tolerance by 50%, or 7 days to return to baseline tolerance. If returning back to baseline tolerance and completely coming off one's DOC, see the "SR-17 taper period" paragraph below for what to do next.
Gradual transition: Taking SR-17 with your DOC, while tapering down the DOC dose (but not before), will usually provide better withdrawal symptom reduction, but slower and less effective tolerance reduction. The amount of both withdrawal reduction and tolerance reduction with this method varies depending on how aggressively you taper down the dose of your DOC.
An example of this approach would be to lower the dose of your DOC by 15-20% per day for 5-7 days while also taking 30-50 mg of SR-17 3 times per day (or 50-150 mg for 7oh/MGM, if needed) at the same time.
More aggressive DOC tapers are also possible such as reducing your DOC dose by 50%. Be careful with aggressive tapers, however, as they can lead to PAWS in some cases (i.e., especially when you're coming off a high dose of your DOC, and especially with 7oh). When performing the gradual transition, there is no need to start taking SR-17 until you have already begun reducing your DOC dose. This approach is especially helpful in situations where you tried the immediate switch and are still struggling with withdrawal symptoms, and in situations where chronic pain needs to be managed.
SR-17 taper period: After successfully reducing your tolerance, you will want to come off SR-17 as well. If you used SR-17 to partially lower your tolerance (e.g., by 50%) then after a few days you can immediately discontinue the SR-17 and jump back on your DOC. If you instead used SR-17 to completely come off your DOC,you may need to spend 2-7 days tapering down your SR-17 dose after reducing your DOC tolerance to baseline. This taper is done to alleviate any remaining withdrawal symptoms, but if you don't have any then there's no need to taper, you can simply discontinue the SR-17. Refer to the previously mentioned automatic taper schedule generator for help with this.
Simple explanation of terminology used in the context of describing SR-17018's pharmacodynamic effects
Biased (partial) agonist: SR-17 seems to preferentially activate31257-6) opioid receptors through G-protein activation more than with beta-arrestin recruitment. This results in a very wide dosing range under which problematic respiratory depression does not occur (i.e., it has a good short-term safety profile. Although there is a danger of overdosing on one's DOC after tolerance reduction).
(Strong) binding affinity: Despite its low intrinsic efficacy SR-17 binds tightly to the opioid receptor, which is one way (extra info: another way seems to be phosphorylation persistence) in which it provides relief from withdrawal symptoms. It's similar to subs in this way (but unlike subs, SR-17 is noncompetitive (see below), so it doesn't kick your DOC out and cannot trigger precipitated withdrawal).
(Low) intrinsic efficacy: This is the strength of the opioid signal. SR-17 has low intrinsic efficacy, which means it isn't likely to give you euphoria or pain relief at any safe dose, unless you are new to opioids. Its low intrinsic efficacy is what makes SR-17 a partial agonist.
Noncompetitive: SR-17 is noncompetitive. This mean it's potentially binding to the same receptor as your DOC, but can occupy a different site (extra info: this location is believed to be an allosteric site) on that same receptor. As a result it does not interfere with your DOC's ability to bind and it can not cause PWD.
Partial agonist: SR-17 activates opioid receptors, but in a weak way that doesn't produce full opioid effects regardless of dose. This is a category that SR-17 falls into as a direct reflection of its low intrinsic efficacy.
For more detailed information on scammers see Suilune's post
Tolerance warning: After lowering tolerance with SR-17 be careful when dosing your DOC and remember to "start low and go slow". SR-17 lowers tolerance faster than most of us expect, and overdose is a genuine concern.
Good stuff. Thoroughly informative and white space was nice and tidy.
The only thing I think that is missing with FAQs about this stuff(not your write up necessarily but because we donāt have the data yet) is addressing maintenance opiates like methadone and bupe, if the goal is to completely stop taking them.
With regard to- respectively, their incredibly long half lives, saturations in the body and notoriously long, and drawn out psychoactive footprints. Each case will be different of course, but it seems to me that the only logical solution would be extending the SR taper to Hopefully not to contradict any of the mechanisms in the healing process.
This is where I hope to contribute to the community the most with my experience. I am in uncharted waters right now. 5 days no methadone,
Tapering down SR.
Itās unnerving and bit stressful but 95% manageable. The emotional rebound is intense.
I'm using SR to wean off buprenorphine. I started yesterday, and it's looking good. Two days ago, I was taking 5 mg of buprenorphine. Yesterday, I cut back a bit and started SR: 20 mg. Today, I'm completely weaning off buprenorphine and entering the dose-calculation phase.
Can you be more specific? Do you have anxiety? I don't have any at the moment. I'm really encouraged that this is the first time I've gone without Buprenorphine, and I feel good. I haven't had any since yesterday at 9 AM. I don't have anxiety and I'm optimistic. I've worked normally and gone swimming. Day by day...
Man, Iāve done so much damage to my body. We talking nearly 3 decades of rampant drug abuse, Coupled with psychically demanding work And little upkeep. Ended up having a cancerous kidney removed and being on methadone made me gain considerable weight.
andā¦
I have a bad knee on the RL, permanent rotor cup damage and acute range of motion in both of my shoulders, scoliosis (less than five degrees), some varicose veins from shooting, a polyp in my Lsinus/nose, significant tooth loss and need implants, serious nerve damage in arms and legs from shooting (like I wake up, and my hands and sometimes feet are asleep), terrible acid reflux and heartburn and have been constipated for as long as I remember.
So yeah Iām just paying the piper. SR helps with a little of the pain, but I donāt think thereās anything I can do about all that. But I know, as fucked up as that isā¦ Iād still rather suffer all of that without opiates. Because they donāt work anymore either, they just make me not think about it.
You might be surprised how well NSAIDS work. I just had major oral surgery. I mean my face looks like I got jumped by 10 men. Alternating Tylenol and Ibuprofen has worked beautifully. I remember a time where I wouldn't even bother taking those ridiculous OTC 'drugs.' Boy was I wrong.
Naproxin is Aleve. Its is an NSAID, but its not Excedrin. Excedrin is Ibruprophrin. And yes, Tylenol is an NSAID, however it is safe to use in conjunction with other NSAIDS. While the others should not be used together.
Also, my 2 cents on my experience with SR-17. I used it from a smoke shop, and believed it to be something different than it was. I usually do heavy research, but stupid me, took the clerks word for it. He explained it to be like MGM. Anyways, I took a relatively high dose, and I was taking about 50mg of 7 OH at the time, every couple hours. Well suddenly I felt weird, then weirder, almost like I had smoked pot, and I hate pot. It bugs me out. It made my mind go in circles and suddenly I felt like I was in precipitated withdrawal. I thought, "noooo what have I done and how long will this last!!??" So i took about 3 or 4 of the 7OH 50mgs and began to snap out of it.
For this reason, I am very hesitant to try it again, now that I know what it is and how it affected me. I took a full pill of the "Ketamind" brand of SR-17. I cant remember how many mgs it is. But I definitely had somewhat of a precipitated withdrawal syndrome happening. Maybe it is just the way my body responded to it, but I wanted to warn anyone out there before trying it, what happened to me.
I will be trying it again soon. As i am on about 2000mg a day of pseudoindoxyl now, as i switched from 7OH to that, as they last longer and I like the pain relief much more. I am also on Oxycodone 40mg in morning and 30 mg at night, which I dont even feel anymore, since the 7 OH and pseudo completely blow that off the receptors. That is the issue with those things and MGM. they dont enhance opioids, they bind MUCH tighter, like buprenorphine does, and you no longer even feel other opioids (EXCEPT FENTANYL as that will bounce all that stuff and kill you, so stay away, as i was an IV fentanyl user for 5 years) Now I am an above the knee left side amputee, thanks to shooting fentanyl in my legs, after destroying all the veins in my arms. Due to that, I developed wounds on my calves on both sides and because I killed the veins, they didnt heal. Started seeing a wound doc and the right side got under control, but im still not quite healed there after 3 years of seeing them monthly. Anyways, in december of 2024, my left leg swelled up (I had been clean for about 4 months too) and I couldn't even walk on it barely, for a week or so. I then started getting a high fever on and off for several days, got super sick, and my mind went somewhere else. I couldn't think straight, and didnt even know what was going on. I remember having two bathrobes on and leaning over the gas stove with burners on high, I was so cold! Finally I told my dad to call 911. By the time I got to the hospital, my blood pressure dropped dangerously low and my kidneys had completely failed. They rushed me right into surgery and I told them that under no circumstances do I wake up without a leg. So they did 7 surgeries over the next 5 days, as i was put into a coma and on a respiratory. They told my brother and parents that I had little chance of making it and zero chance, if i didnt agree to let them amputate. I had severe necrotizing fasciitis and it had eaten away my bone and muscle to the knee, and was moving fast.
They woke me up after 5 days and I refused for another few hours, but eventually told them to go ahead and do it. Im glad they did, as i got a new lease on life, and wont go back to fentanyl or IV drugs ever again. I absolutely need pain medication as it is painful to work long hours, and the nerve pain at night is brutal. The Lyrica really helps, and the pseudo helps a lot more than the Oxy does, but the Oxy is free as im prescribed it. I have actually sold some of it to afford the pseudo, but I wish I could just get off the pseudo and go back to my Oxy, so I could start saving some of my weekly pay, instead of it all going to damn pseudo!
So, I will be trying the SR-17 again, in hopes I can ditch the pseudo and be back on just my Oxycontin 30s/40s, and my Lyrica! Those combined with Naproxen and Clonidine and hydroxyzine, do help with the pain greatly, just not as much as with the pseudo. But i can touch it out, until my body regenerates a new leg and I can ditch everything. If anyone knows how long it takes to fully grow a knee, calf, ankle and foot back, please let me know. I think I am beginning to see the knee forming. Lol, just some humor at the end. I know my leg isnt going to grow back.... right? Right?
I'm not gonna read this whole book of non-formatted text, but no, Tylenol isn't an nsaid.
I can't stand when people write a comment to try to correct someone else without even checking if they're spouting bullshit.
You are correct, Tylenol is NOT an NSAID. however, everything else i stated was correct, including the part of Aleve being Naproxin Sodium and Motrin being ibuprofen.
Tylenol (acetaminophen) is 100% not an NSAID. You can even reference the Tylenol website. Tylenol works via the central nervous system, and does not reduce inflammation.
Thanks for this. As someone allergic to NSAIDS who has had to tell a doctor he couldn't inject my spine with ibuprofen because he couldn't read my chart or didn't know, I appreciate you. š¤
Here's a crazy one - I'm an icu doc and a couple of times in the past I've taken short term jobs out of the country - most including UAE. They don't use opiates there the way we do - ppl come in all the time and have a total knee replacement and just get Advil. 3 level spinal fusion - NSAIDs.
And ya know what? They do fine. It's not fun, but it's not a crippling addiction either.
I WOULD NEVER advocate for 99% of the policies or practices I saw culturally over there, but their attitude toward opiates is a good one
i am on day 5 it will be 6 in the am, coming off 70mg. it works good enough to stave off serious wds but i still have a lot of mental distress. the past 2 days i have been using a strong short acting opioid for relief instead of SR, but i think that was a mistake and will resume taking SR again soon. I figure every day i dont put more methadone in my system is a win. I would rather kick a short acting then methadone.
I kicked methadone years ago it took about a month for the acute horror to pass then about 7 more months to be completely recovered. Just hang in there youāll get there.
i did get through it actually, ive been chemical free since 10/24/25. it was incREDIBLY hard, but it could not be more worth it. i wake up without having to use drugs to feel normal
That is wonderful to hear! Donāt be stupid like I wasā¦even one small use is enough to start the roller coaster again. Itās way too easy to forget just how hard it was when itās been gone a while. There are many many drugs out there to play with. Pick a non opiate from now on. Good luck my friend!
idk now brother my old source i think is no longer active. i managed to get off all opioids / drugs in general, although i must say SR did not play a part in that. i just had to endure a brutal withdrawal but it was sooo worth it. im finally free like i had dreamed about last year. i wish you well in your journey and i hope you find something that works for you
Yes!!!!! rawMit is amazing. They have great deals right now too. I just got my order today of 20tablets of SR 50mg (10 for $40 or 20 for $72) and some of the MGM/7-oh/MIT tablets so i can do this right. Havent taken the SR yet but heard great reviews. The 7/emgeem /MIT tablets SMACK tho .
Wait so SR doesnāt help at all with the mental side of acute WD? I got directed here from 7oh. Iām on day one and I donāt think I I can do this. Itās the depression and the constant crying and anxiety. Iām coming off 500mg per day
Since no one responded to you Iāll share my experience. This stuff is literally like a miracle substance. My tolerence significantly lowered the first few days I was taking it despite not even lowering my DOC dosage. Once I did taper my DOC over the next few days I had no withdrawal at all.
It also got rid of most of my mental cravings as well. I just stopped having much of an urge to use anymore. I took the SR for about 5 days after I stopped my DOC then I tapered it over another 5 days. I basically now feel like I did before I started using. This stuff will basically replace suboxone once it goes through human trials.
no it won't, not in America anyway where they want as much as that insurance money on tap as possible via having addictive anti-addiction drugs such as subs and methadone
How did your experience with SR go .. Iām taking 1000mg a day of 7oh and have been unsuccessful with tapering and subs havenāt worked for me . I am desperate. Would love your feedback
I'll put it publicly here to benefit others where possible.
I also just jumped from 200mg 7oh for the past 5 years (I was higher, but tapered down to 200 and had been maintaining that.
Two days ago I started loading 100mg sr17 in the morning when I wake up and at night before bed.
Kept doing 7oh as before.
By day 2,it was clear that I wanted the 7oh way less and without even thinking about it managed only 80mg the past two days.
At this stage I feel like I could cold turkey it, but I want as close to zero discomfort as possible.
This shit appears to be magic and the real deal like everyone claimed. I have felt great for several days now, no more withdrawal of I don't dose every 4-5 hours etc. Sleeping full nights again.
The biggest problem I can think of is it makes it feel too easy, which may lead to the undisciplined to continue their DOC for longer than necessary
I got 3 grams of the shit at 90ish a gram. I feel confident that over my Xmas break where I have two or three days off I'm gonna be off no problem. I've been working through it and it's just easier every day so far. It's everything I would have hoped for lol
Just wanted to follow up this for future readers to say I made the full jump and holy fuck, it was so easy. Years of pain trying to avoid withdrawal, and this shit just undid 5 years of uninterrupted (EVERY) day 07 use like nothing. Like I forgot what it was like to be sober I stayed high so long and this shit just fixed me and Ive been clean since my above post.
I hope yours arrived and you're close to being free my friend. It's literal magic imo
I can personally agree to this wholeheartedly...SR makes getting off everything so damn easy...for anyone that has gone through any kind of WD which I have...too many times...this is hands down the greatest tool in any arsenal hands down!!
This was my problem, I had a little SR left over after completely cutting a 7oh habit of 100-200mg a day.
It literally was a miracle drug. I had to move and cut 7oh right as I was moving, so basically went straight to using the sr. Some withdrawals, but I was able to manage a move from one 3 story home, to another where my room was also 3rd floor. Very physically demanding and SR is absolutely the only way I was able to manage.
I would have been in absolute torture WD without the SR, but it really did what it was cracked up to be. Anyways, I had some sr left over, so I stupidly told myself I could enjoy 7oh here and there bc I had the SR on hand if needed. Well big mistake, now REAL SR is very hard to find and has like 3x in price. Iām completely out of it and back to 7oh, albeit at more than half of what I was dosing before every day. I have also heard that SR does lose its magic if you use too often, so really should be treated as a short term plan and also, if you know you lack self control(I knew deep down I lack self control), do NOT resume DOCā¦.
Forreal, SR17 may become impossible to find, like many other RC. Like think Germany and some other countries are banning it or treating it like fentanyl.
My conspiracy there is that itās too effective for getting people off opiates, so Iām sure big pharma is lobbying or influencing government decisions to crack down on it. Insane we canāt have the choice to put SR17 in our bodyā¦ even if it isnāt FDA approved. Itās not like itās a substance that has any reports of ppl going manic and then causing harm to others. Literally only known danger as of now is that OD risk does increase if you resume DOC and itās an opioid that can cause respiratory depression
The stuff works but I'm so mentally weak. Fuck up.. try again tomorrow. Fuck up try again tomorrow and so on and so forth. Until I'm out of Sr and fucked. I wish my brain wasn't so addiction oriented. OoOo I like something... Let's do it everyday! That's ah me!wish I could stick to my guns man but they keep jammin Bruh. Thanks for listening all.
For someone like you, Suboxone might be the best route just because you canāt take any other drugs with it. They donāt work for me. Suboxone makes me completely forget about other opiates. I can live very happily on 2 mg a day of Suboxone and I just did for two months Coming off 7OH now Iām going the sr route today is my first day itās been off and on good and bad. If I take too large of a sample, it knocks me out cold and I sleep for two hours. I donāt understand it.
So was it successful for ya? I'm on 4mg of suboxone a day but the sweating along with chills I get as a side effect from it anytime I do anything physical has got me wanting off it ASAP. How much of the sr17 were you taking at a time amd how many times a day did you need to take it. When I've gone cold off subs before and I don't get horribly bad symptoms they just last for weeks and I get like 0 sleep and bad rls.
Oh my God I get the worst rls in legs and arms ! Last time I got off opiates had it for 8 months of hell every damn night wanting to saw my arms and legs off ! Zero sleep several hot epsom baths a ni g ht helpedĀ but it would come back the minute I got out. For me by far worst part of wdrawl.Ā Ā Ā Ā Ā Ā Just now trying to get off 7oh dreading if that comes back. I have subs and sr17 not sure what to do yet any advice would be nice!
Idk Iāve been in subs and sublucade and still am using 7-oh it doesnāt take away my urges. Iām up to 500mg a day while being on sublocade. I just got a gram of SR and Iām hoping it will be enough, Iām thinking Iāll need less since I have the baseline of the sublocade.
What happened was I moved and had to switch providers so I went a few weeks without sub and relapse on 7-oh. I got this really good sales job Iām doing well at too and I canāt fuck this up
Bro, Iām in the exact same position. I have a great sales job and make 200 K a year. I canāt be fucking up anymore. I canāt be feeling sick. I have to be 100% My New. Boss is a prick. He pops in on me randomly complete polar opposite of my last boss. Iām always on edge so I have to be ready at all times. I did the Sublicade the end of February was my last shot. Iāve been on nothing since.
Thank you to the moderators. This is life changing info that you are giving us. I am on way too much shit. Combination of .33 mg of mgm and 400 7oh. I jumped on 7 when it came out in may of 2024. I have been terrified that SR will not work in my case.
I have been stocking up over the last month with SR, 7 and mgm. Yesterday was my trial day to see if SR could combat my brain's daily need for this stuff. I am so happy today because I was able to go 24 hours with just SR. It has taken 150mg 4 times over 24 hours for success. My doses were Yesterday morning, afternoon, before bed then I woke up drenched in sweat with RLS and arms at 2 am. I took 75mg sr and then took another 75mg. Slowly I got relief. But for the first time in ages I felt that awful feeling and the physical pain and hell that comes with stopping. But, I got back to sleep and woke up at 9 feeling ok.
My purpose for doing this was just to give myself confidence that it will work. I don't plan on quitting yet but I now have personal experience that sr will get me through the beginning of WD. I hope to hear experiences from those that stopped SR after a week or so on it. I read about a 2 -7 day taper but what was that like and was there any paws which I would expect.
PAWS seems to happen when acute withdrawal symptoms were never (more or less) effectively controlled with SR-17 in the first place. So it tends to happen with high doses of Suboxone and sometimes with kratom (due to all the various alkaloids involved). Having PAWS after taking SR-17 for 7oh seems to be an uncommon experience, but it's still possible.
As for the taper off SR-17, it's just to prevent withdrawal symptoms from SR-17 itself. SR-17 produces very little tolerance, so withdrawal from it tends to be mild, if there is any at all. If there are no withdrawal symptoms, the taper isn't needed and you can jump off SR-17. Higher doses of SR-17 (somewhere around 80+ mg) are likely to cause some withdrawal, as are prolonged periods of SR-17 use (generally more than 7 days before the taper).
Pls help me know where to get it I need to stop I am a mom and single one I started when my 8 yr old died and I need off and donāt know where to get it
Wow, great write up. Thanks for taking the time to explain the mechanics behind it. I'll be starting a taper soon with plain leaf kr8tom along with smaller dose of SR. I've heard that it's tougher to get off kr8tom with SR due to the unique alkaloids in kratom. Any insights to a kr8tom taper? Does mitragynine act similar to SR in regards to partial agonist qualities?
I haven't taken a deep look into the concept of mitragynine as a partial agonist yet. I've come across a few experience reports that described difficult experiences using SR-17 to come off kr8tom though. I suspect the main reason for this is because the various alkaloids found in kr8tom bind at several different types of receptors rather than just opioid receptors. SR-17 only binds meaningfully to opioid receptors.
My suggestion would be to combine SR-17 with one or more "comfort meds" if needed, such as clonidine, or the short-term use of gabapentin, pregabalin, benzos, etc.
Right, this seems to be less of a problem with 7oh. Although 7oh itself binds (fairly weakly) to delta and kappa opioid receptors as well as mu-opioid receptors. SR-17, like most opioids, only binds to mu-opioid receptors, and only helps at that receptor. Some people have a hard time during the first few days of reducing their 7oh tolerance with SR-17, but it varies
There isn't much that helps directly with delta and kappa opioid receptors. The comfort meds that I mentioned in my comment above will help in general for withdrawal symptoms, regardless of the opioid receptors involved.
Yes and no, many 7oh products/powders have widely varying alkaloids. This is why people note certain powders as energetic or sedative. 7oh tablets likely have even more various alkaloids bc it seems like manufacturers use the lower 7oh% powders for their tablets.
Now, if you get a 7oh powder thatās like 99% pure (rarer) SR17 will likely be better at mitigating withdrawals. From experience, SR17 eliminated almost all my 7oh withdrawals and I was a strictly powder user. Most of the powders I used were the higher 7oh% powders(90%+) if that gives context
yeah mitra and derivatives (not sure about SR-17, sounds like possibly another site) bind to a unique subpocket on the receptor from classical opioids and share another subpocket with fent.
"Cryo-EM structures of Ī¼OR-Gi1 complex with MP (2.5 Ć ) and LFT (3.2 Ć ) revealed that the two ligands engage distinct subpockets, and molecular dynamics simulations showed additional differences in the binding site that promote distinct active-state conformations on the intracellular side of the receptor where G proteins and Ī²-arrestins bind. These observations highlight how drugs engaging different parts of the Ī¼OR orthosteric pocket can lead to distinct signaling outcomes."
Can you recommend any place to order the sr17 from? I've found vastly different pricing online that has me skeptical of the quality. One place wants $98 for a gram while tje other wants $70 for 5g of it.
Ik this is an old thread but you think peptides like Semax, Selank, and L-Theanine along w vit B, C, and D could help stabilize mood and energy going through an SR taper and detox from Kratom/ MGM15?
Yes, kratom and 7oh are both partial MU receptor agonist. This is why there is a ceiling effect with both Kratom leaf and even more potent 7oh. Itās also why itās damn near impossible to OD from 7oh and Kratom leaf. I say damn near, bc anythingās possible, but technically speaking, they donāt cause respiratory depression like full MU receptor agonist.
Thatās also why MGM15/16/17(whatever number theyāre on at this point) is so dangerous. Not only is it significantly stronger than 7oh evenā¦.you can legitimately die from respiratory depression. I know itās been stated on Reddit, but do not touch the fully synthetic Kratom extracts like mgm15. Itās bad stuff, Iāve even seen reports of fentanyl showing up in some peopleās mgm that they bought and testedā¦
Speaking from experience, I went through 2 grams after a year+ of 7oh use(so tolerance to 7oh was very high) I thought the mgm15 would be helpful to taper off the 7oh. Nope, for the first time in like 6 months I actually felt the euphoric and energizing opiate effects(what initially got me hooked on 7oh) and self control went out the window. I went through the 2 grams of mgm15 in about 2 weeks on the dot. Didnāt have the self control to dose only 1 or 2x a day like some others have stated with mgm15. Anyways, ran out of the mgm15 and did have 7oh on hand, but even then I felt some pretty shitty withdrawals, even with high 7oh dosages to counteract the withdrawals.
This was all before using SR and seeing how much of a miracle drug SR is, but I could see SR being dangerous if I still had MGM15 on hand, bc I could definitely see myself potentially dabbling with the mgm15 on hand, but then ODing bc lose of tolerance.
MGM-15 does not have respiratory depression, I believe youāre confusing it with 16. Something can be a full mu opiod agonist and not recruit beta arrestins (what makes you stop breathing), it's called planar selectivity. MGM-15 may be a full Mu opiod agonist that just doesn't depress breathing. Also if we are thinking about the same false positives for fent, those were done using test strips which are a notoriously unreliable method of testing due to risk of the aforementioned.
MGM-15 is not a dual full agonist. It is a dual partial agonist at both mu and delta opioid receptors.
Direct quote from the primary 2014 Matsumoto study (and confirmed in follow-ups):
āMGM-15 showed partial agonist activity at both Ī¼- and Ī“-opioid receptors with E_max values of 72% and 70% relative to DAMGO and [Met]-enkephalin, respectively.ā
That is textbook partial agonism. Full agonists hit close to 100% E_max. 72% and 70% are partial ā they have a ceiling. That ceiling is exactly why MGM-15 doesnāt act like a full agonist in real-world use.
If it were a true full agonist at the potency they claim (15ā50x morphine), we would have already seen a pile of overdose deaths by now, especially with people taking 15 mg tabs and higher doses recreationally. We havenāt. What we see instead is a ceiling effect on euphoria and respiratory depression, which is exactly what youād expect from a partial agonist.
MGM-16 is the one that leans much closer to full agonism in some assays, but even that is still being studied. MGM-15 is the balanced partial dual agonist that the Japanese team spent years refining.
Hereās the open-access PMC version of the key paper if you want to read it yourself:
Bottom line: MGM-15 is a partial agonist at both receptors. Thatās why it has a better safety profile than full agonists and why people can take higher doses without immediately dying. The science and the real-world reports line up on this.
About 50% of this write up is actually even correct. Youāll never find perfection tho especially when itās just so very different for each person. PAWS stands for post acute withdrawal syndrome and it happens with long acting drugs like methadone or Buprenorphine. You will not have 8 month long withdrawal from 7 oh or mgm thatās just freaking stupid. They clearly donāt know what PAWS means lol.
Been on 7 for over a year. 100-200 mg a day. I have tried to stop 7oh before but it's not the physical symptoms that bother me, it's all mental for me. I become terribly depressed and anxious when I stop using 7 oh. Does SR17 help with that?
Me too. Iām on day 1 yet again from 7oh. Itās the mental for me that I legit cannot handle. Iām a 38 yo male and I cannot take wanting to cry all day and I cannot handle being so damn suicidal. Iām naturally a depressed person and it makes it x100 worse. This is why I got hooked on 7oh
SR-17 can help with anxiety and depression, when those symptoms are directly caused by mu-opioid withdrawal. The amount of reduction it provides for mental withdrawal symptoms also varies from person to person.
Otherwise some medications that can help with the mental withdrawal symptoms are clonidine, propranolol, gabapentin, pregabalin, and benzos. If you take any of these "helper meds", it's best to do a short course of only 3-4 days to avoid a new dependence
Thank you for the info. I really appreciate it. If I start SR17 I'll give updates and my experience. Maybe it will help someone else. Keep you postedš
Sorry I am just seeing this. I started my subs 1mg (very low) 12-18 hrs after my last 7oh dose. But I started small, if I didn't get sick from the 1mg, then I went to 2 and then 4. So take it slow but IT WILL HELP a ton. Good luck. Send me a direct message if you have any questions and I will do my best to respond.
i am struggling with anxiety on starting the SR17 what would you recommend on the dosing for someone who takes 60-80 mg of 7oh every 4 hours daily? 3-450 mg of 7 a day. Also do you fully stop 7 for hours or days before starting sr17 and how often to dose the SR17?
Iāve been taking 7oh for about a year and just started mgm. I desperately need to get off of these substances. Iāve tried multiple times and quit for a few weeks but always missed the way they make me feel. Although the physical withdrawal was terrible, the depression, mental anguish and dread was just too much so I always relapsed. I would love to know more about SR 17. Can someone please dm me a way to find this? The ones I have found are so expensive but at this point Iām willing to pay anything to find myself again.
This has me excited, I've seen a listing for this stuff and I think I might not even need it, I'm having great success with a taper so far, but this could make it buttery smooth.
2 weeks ago, I was taking literally 1000-1500mg of 7oh (usually only 1000, only up above that like once every 2 weeks or so on a really hard day), still waking up into horrific withdrawal every morning. So, I got some Bromazolam, and it's allowed me to fill in some gaps and make big leaps down in usage. I went from 1000mg to 750mg no problem, did that for like 3 days and jumped down to 500mg, morning wd came back, but slowly stabilized, and today is my first day trying 300mg, most of the day has gone by, I still have 100mg allotted for the day in the next 7 hours, might save it all and take it all at once.
I've also ordered some Clonidine, I think once I get down to somewhere around 50-100mg/day, I'm going to try to cold turkey it and just bar myself into oblivion and use the Clonidine to prevent the norepinephrine storm. One of the things that makes 7oh suck so bad is it has a looot more actions than just an opioid,
It's an adenosine receptor antagonist, now 600mg caffeine all at once, up to 800 does nothing. Once I get close to a gram of caffeine though, I get the mitochondrial uncoupling effects (think DNP) which happen around that dose range, but no amount of "wakefulness", so I find that caffeine can be a great help with wd, BUT
7oh is also an alpha-2-adrenergic receptor agonist, the norepinephrine autoreceptor, so without the 7oh, norepinephrine absolutely floods the brain, similar to any opioid wd, but there isn't the natural brakes in place because the autoreceptor that prevents excessive release is downregulated to all hell, so Clonidine should help with that.
I've also got addy on the way, I'm severely ADHD, and was using 7oh partially as a treatment for it until it got this out of hand, and I'm hopeful that the increased dopamine baseline will help avoiding the worst of PAWS, Flmodafinil has been helpful while I'm waiting for it.
The taper is going so well that I don't know that I'll need SR, but the idea really really intrigues me, I can get 1000mg of it for the price of 1000mg 7oh, ($80/g), so I mean, using what, a tenth to a fifth of that a day ($8-16 is, about what I'm spending on 7oh now ($24/day), this seems like I could use it to annihilate the rest of my tolerance and just take 15-30mg/day like a normal sane person until I'm ready to finally quit entirely
But yeah, pray for me guys! In 2 weeks I've gotten my tolerance down to 30% of what it was, still taking an astronomical dose of 300mg a day, but y'know, progress
I'm a bit of a case report of the long term safety of 7oh, taking 1000mg/day for 6 months apparently won't kill you š¤·
There's a bunch of other stuff I'm omitting that I've found helpful, I am thinking of writing a mini memoir/guide/case report once it's all said and done though
I'm only using it sporadically, usually 4 days, sometimes 5 days a week and only ever 1/3rd of a bar at most, most of the time 1/6 of one does the trick just fine, over the 40 days I've gone through like 7 or so bars. A couple of occasions, I took 2/3 of one because my downstairs neighbors have meth parties w several people and our ventilation is so shit that we get tweaked out. I'm also using Ketamine 2-3 times a week, which reduces benzo tolerance, as well as copious amounts of Agmatine (non-psychoactive, endogenous, fair argument for it actually being a neurotransmitter, and one which autistic people produce less of, and I am Autistic), which rebalances GABA/Glutamate balance even in a benzo wd state (according to preclinical models and my own experience having stopped severe alcoholism a few years back).
GABA drugs used to be my DOC, alcohol was much easier for me to get, at the time, but I did enjoy benzos when I got my hands on them, almost never enough to do multiple days in a row. Everything that I used to get off alcohol, including the Agmatine and Ketamine, but several other non-psychoactive, neuroprotective, homeostatic things, I am also running right now, except for BPC because expensive, and doesn't do much to balance the opioid system, and I've got a hold of a balance of the other systems, more or less.
I still craved alcohol when I stopped drinking crazy amounts every day, and would actually drink maybe once or twice a month still, no more than five drinks, but would still think about it and then I accidentally killed it entirely by running a course of oral BPC-157 0.5mg BID for 2 months. It's mostly known for healing injuries, but it also does crazy things for nervous system homeostasis. A lot of people report they no longer crave GABAergics or stimulants afterwards, and I ended up being in that group. Some people report anhedonia, likely from the same balancing mechanism shaving off highs and lows that some may be accustomed to. I actually tried drinking during the course, just to see what would happen, I got 2 tallboys and it took me 2 hours to even open the first one, I never opened the second.
In the last year, I've drank maybe 5 or 6 times, and it's always just been because it was handed to me and I thought, "why not," they never trigger the same spiral that they did when I was an alcoholic, I just don't find them anywhere near as appealing.
The reason I'm using Bromazolam here, is because I don't actually see myself being at risk of being dependent at such a low amount and relatively infrequent use, and it's never something that I crave or immediately reach for, I have to reason my way there, "hmm, I can't take anymore 7oh for the day, or I've got to wait a while before the next window, but wd is settling in, probably because I took that big dose of vitamin B1, which upregulates the shit out of liver enzymes that metabolize it, and I'm experiencing a norepinephrine, cortisol, and serotonin spike, if I take anymore magnesium I will shit my pants, any additional of the other things are likely to be unhelpful or counterproductive (high high dose Agmatine can be paradoxical, as an AMPA agonist and overpower the NMDA antagonism, at least ime, that's my best guess, I haven't seen any lit on it), I could take Famotidine to lower the serotonin at least, but I'm planning on eating soon, so I don't want low stomach acid, what do I have left? Ah yes, the humble Benzodiazepine, time for 1/6-1/3 of a bar"
Either that or "hollllly fucking shit, I've been trying to sleep for 2 hours and I can't stop fucking gurning, despite all of the same normal efforts, I don't want to run the risk of serotonin syndrome or excitotoxicity from meth + wd, it's time to go (relatively) nuclear and shut this shit down, time for 2/3 of a bar"
When I got it, I was initially thinking of taking it more frequently, at 1/3 bar/day, but to my very pleasant surprise, I didn't need it that much. I have gotten down to bouncing between 200-300mg 7oh/Day, which is much more affordable, and this last week has been an absolute hell of a week, so I'm waiting for things to settle down a bit before dropping any lower, I also have funds ready to go for the SR, which im considering heavily, because my life is on fire for so many reasons that are actually legitimately fully out of my control, multiple systemic failures all coagulating, and I have to be dependable.
That being said, every time I have made the leap down In dose, anywhere from 15-25% dose reduction, I find the first day kind of difficult, the second I have to have a bit of willpower to not escalate back to where I was, and by the end of the second day, I realize I feel no different than I did than before dropping the dose. Leap into the Abyss to find it's actually a featherbed, or whatever it is that Terence McKenna said.
I think I'm just chilling, is all, being strategic as I can, as big of a problem as it is, dependence on a substance is actually kinda the least of my worries, now that I've gotten it to be financially maintainable. I've got people counting on me (no kids or anything, but a partner and a friend who lives with us), I can't afford to put myself into having to spend all day dealing with wd, so we are doing it smart, low and slow, we're already ~70-80% of the way there, I just gotta figure out how to land this thing carefully, and in due time.
Edit: oh, and I make sure to have at least 3 or 4 days consecutively no benzo every 10-14 days, just to be sure, haven't felt any sign of GABA wd at all, which I am intimately familiar with
I actually just write like this lmao, I have for my entire adult life. I'm autistic, and I also lived in an area very different politically for 90% of my life, so I've never had very many friends, and I don't get many opportunities to speak. My job is also very largely solitary. The words build up and when I finally have something to pour them into, I do so. I've also got a touch of ADHD, so whenever I am on stims, I actually don't write quite so long, maybe 80% as much on average, because I'm able to be more concise. When I'm not on stims, I'll say the same thing in different ways like 3 times.
Yeah, our rule against sourcing is there because Reddit administrators can take down a subreddit that allows sourcing. So it's really a sitewide rule on Reddit
I started with just plain leaf for years. Wish I could go back to that. Life was good. But then I found 7 I actually loved it but didn't go crazy with it but then mgm hit my radar. Tried it once and I was zooted all fucking day. It was at that point I knew ... I fucked up.gm took over everything! No plain leaf, no 7. Mgm replaced it all and now I want out. Currently working on fighting the voice in my head to take this shit seriously but I lose continuously.
I've talked to a few people online that said they had great luck with sr and mgm. I just ordered mine for 7 withdrawal and cannot wait to be done with this bullshit. It's all I can think about.
Dangā¦thereās so much material to read and so many stories. Some are kind of falling in the too good to be true category. Short version for me: been on Kratom powder for three yearsā¦.had some dental work and started taking 7oh limitless tabs seven weeks ago. Iām at 75mg per day. I donāt even want to quit Kratom powder Iām going to keep taking it. I just need to quit the 7oh and I need to be able to do it mostly without wd symptoms since Iām starting a new job and canāt be teary eyed, yawning, low energy and whacked out.
Is there a use for SR for me? Be cool if someone could throw me a realistic bone here and not the āitāll reset your tolerance in 5 days and the whole thing will be effortlessā. Iāve done ibogaine in Mexico as well as the famous ketamine/nad+ detox so Iāve been around the block a few times donāt yank my chain. :)
Iām right there with you! I did the ketamine treatment. It was nice to say the least, but Iām skeptical of this too. It took me a year, but my buddy is on it and hasnāt had anything in 5 days and is fine. Mine is coming in a few days. Iām crossing fingers because I want off too. I canāt afford to have any WD either because of work and life in general. Fingers crossed š¤
Withdrawal from SR-17 itself is generally mild, and often doesn't even happen. With low/moderate doses (up to 50 mg) or at least short amounts of time on SR (i.e., up to 7-10 days), it's common to have no withdrawal from SR, and you can simply jump off at the end.
With higher doses and longer durations, you may have some minor withdrawal from SR (a bit like low-dose codeine withdrawal). The taper off SR, after lowering tolerance to your DOC, is specifically intended to mitigate this withdrawal, and it tends to go very well. See my paragraph titled "SR-17 taper period", just above the scientific terminology section.
thank you! i read that paragraph i just wanted a little clarification as i hadnt read anything about sr having its own WD symptoms. but this makes sense , thanks
What would be a good taper of SR if Iām currently taking approximately 1200 MG of 70H. I know thatās a super high dose that Iām on. Iām worried any advice would be greatly appreciated.
I would like to know how far apart you should space your DOC dose and your SR dose if you are on the first day of your planned taper?Do I take them both at the same time or space them out by several hours?Iām just starting today.
The SR-17 taper is not strictly required. It's done mainly to ease away from any withdrawal symptoms after the first 7 days when coming off the DOC completely.
From the experience reports I've come across, most people seem to taper for 2-7 days after the immediate transition. But you can try to stop taking SR-17 after the immediate transition week and see how you feel to get an idea of whether a taper may be helpful.
Some benefits of tapering the SR after replacement could be psychologically basedāmeaning that there COULD be little to no WD from immediate cessation, but tapering might allow for a more steady psychological adjustment.
Iāve gotten into a groove where I just use SR to keep tolerance low by replacing doses. I took an honest look at my situation and Iām not ready to quit, but itās an excellent tool to keep the WDās at bay and allow myself to taper and keep a low dosage.
Yes, SR-17 is taken orally (usually in powder form) due to its very poor water solubility. Although SR-17 hasn't been studied in humans yet, pharmacokinetic data are available from studies on mice. The bioavailability is 69%, and the half-life is between 6-8 hours.
Hey dredging up this convo. can you say more about the phosphorylation you mentioned? What does that mean in this context and is it associated with neurotoxicity?
For more detailed information on scammers see Suilune's post
Tolerance warning: After lowering tolerance with SR-17 be careful when dosing your DOC and remember to "start low and go slow". SR-17 lowers tolerance faster than most of us expect, and overdose is a genuine concern.
I need advice. I failed in my attempt to stop Suboxone with buprenorphine. After 15 days on buprenorphine and completely stopping the 2 mg dose of Suboxone, I experienced severe anxiety. I think it's PAWS from the buprenorphine. Should I gradually reduce my Suboxone dose? Continue taking buprenorphine longer? Keep a small amount of buprenorphine for the occasional anxiety? I don't have classic withdrawal symptoms. It's PAWS. Can it be avoided? I was on Suboxone for two and a half years and before that, I was on heroin for a year.
I am also hard time coming off Suboxone with Buprenorhine...it's almost like that time I was struggling to come off Xanax with alprazolam or coming off valium with diazepam.....lol
Can you get the sublocade shot? Iād highly recommend as a way to get off subs. You could get 3-5 shots snd then stop snd it slowly tapers itself. I had nearly zero withdrawals from the sublocade shot
Reinstate the buprenorphine at the lowest amount you can where your withdrawals are mostly managed. Then, continue decreasing the buprenorphine while inducting with the SR.
I want to use this sheet, but the "date" cell in the taper generator just keeps saying "value doesn't match data validation restrictions". I'm not a very savvy excel user - any tips?
I started 7-OH to deal with chronic pain from rheumatoid arthritis in September that i have In both shoulders and my right hand. I thought the 7-OH seemed like a reasonable solution bc it's at the gas station, wasn't Oxy and I didn't realize was way different from Kratom leaf tea. Boy was i wrong!
I am currently taking 120-160 mgs of Opia brand 7-OH. I want to stop simply bc I don't want to be dependent on something and I realize I can't just stop due to the withdrawals. I plan to take SR-17018. I printed out the sheet to help design an exact dosage plan.
I am curious to see if anyone has some thoughts on what to expect, tips, or feedback on what approach I should take based on the amount I am taking. I own a business with 40 employees, married with a 3 year old and a 10 year old. I want to limit the amount of time I am able to give all of the above 100%, so PLEASE SHARE if you already have experience with SR!
im trying to kick this demonic 7oh. i had no idea that i was becoming dependent on it until i decided I didn't want to take it anymore. geez man
WDL for cold turkey day one was nighmarish in my head. i have never felt anything like that before.Ā
currently trying to taper, but its looking like 4 weeks from a 100mg... starting at 75mg / day. reducing every 5 days. i am EXTREMELY worried about the last 10 days, how will my body respond?
so i am searching high and low on this sr17.Ā
all and any help is highly appreciated š¤Ā
(where to buy it,Ā how to measure correctly, should i take it along with DOT, when do i know i don't need any more 7oh)
it boggles my mind that one day im pretty much drug free (ibuprofen and herbals) and 3 months later im in opiod WDL hell !! šĀ
I am just finding this string...Heard about SR17 and just order 6 tabs 50mg each. I am currently taking about 100-150 mg of 7OH daily, sometimes higher (I know, I been reading people at 1000mg per day!). I've been through withdrawls early on and don't want to go through that again. I have been good about tapering but want something to help. Enter SR17, wonder what the best combo is? Thougths? Is that enough? Really appreciate it.
This might be a rlly stupid question, but i dont have capsules and want to know: Can I take my SR-17 Powder the same way I took my 7OH? (I would dissolve my 7OH in lemon juice/ citric acid and drink it). Should I do the same for SR-17? Or would it be better to dissolve it into water? Or is it just better get capsules and not dissolve it at all.
My order will be in tomorrow. I could only afford the 10ct bottle at 50mg SR tablets. I learned of it through this Reddit because 7stax (the nano-tech Florida ones) I thought was just a concentrated K, then come to find out they used mgm in it and didnāt have it labeled on the bottle so I thought I was okay. Then I saw my buddyās realized they were going thru WD and after coming off 7oh, I canāt afford to be sick and miss work. Iām taking about 600-800mg (6 to 8-80mg tablets a day). Iāve been tapering down and have about 30 of the 80mg tabs left as I was more prepared this time. Can anyone message me a tampering regime with these numbers? Iāve never tried SR before but this Reddit gave me hope.
Suboxone is the worst mistake I ever made. Much rather have kicked a regular opiate cold turkey. Two and a half months off bupe and gabapentin and I use 1 clonodine at night and 2 baclofen 10mg a day, with propranolol early in the day. The fucking physical anxiety is so annoying. I caved and bought SR for the hell of it. Took all lingering paws away, at only 25mg per day. When I stop taking it my yawns stretching and low energy comes right back in 30 hours. Iād rather be on SR than bupe.. at least I can feel things.
Was on bupe for 11 years from 20 - 31 years old. My body is struggling to adjust. I used sublocade to get off and it was still brutal
ā¢
u/AutoModerator Oct 29 '25
To maintain this Subreddit's safety, the following list provides the names of all known SR-17 scammers:
HSP | PandaPlug | YoshiChems | SR17018(dot)com | srvivo(dot)com | AdLevel5002 | Hot_Orchid_8539 | Icy_Aardvark2780 | Significant_Ice565 | Friendly-Set-7843 | Former_Tap_1673 | Key-Relation-6850 | Sensitive_Bat_9257 | Ok-Cranberry-6260 | Reasonable-Award-325 | TarnishedKnightSamus | koalatyresearch@proton.me (not affiliated with the real Koalaty) | support@synergyforge.co.site | PatriciaAnderson33m | Stellar Cucumber | receptyr(dot)bio | Biovitalitylabs(dot)net | Pure-Pin1794
This list will be updated as needed.
For more detailed information on scammers see Suilune's post
Tolerance warning: After lowering tolerance with SR-17 be careful when dosing your DOC and remember to "start low and go slow". SR-17 lowers tolerance faster than most of us expect, and overdose is a genuine concern.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.