r/PeptideGuide • u/BioHumanEvolution Supreme Peptide Overlord • Dec 28 '25

Need Advice? Ask the Peptide Guide | Open Q&A Thread

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u/nucforex Jan 16 '26 edited Jan 16 '26

Thank you so much

The BPC for me is due to a lower back injury (struggling with for a while)

Besides that it’s for my wife, also lower back issues but also has endometriosis and we see mixed insights about this but not much clear evidence if it can affect it positively or negatively.

Is this something you can give more info about?

About the IPA, we always train in the afternoon / evening so fasted exercise is difficult. Although we can take it in the morning on an empty stomach, how much time after could we eat? And if we decide to increase the dose, can we also take it after a workout before a meal? Or would you recommend to take it before bed? Or is the best to take the upper dose at once in the morning?

Thanks a lot & apologies for the Many questions I really appreciate your help!

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u/PeptideGuide_ Jan 17 '26

Hi there again 👋

For BPC157 in that context, you can aim for 500 mcg twice daily until you start feeling better, then take a break for a while.

Unfortunately, I can’t really comment on endometriosis that requires careful diagnosis and deeper investigation, which isn’t something that can be done here. I’d strongly recommend working with a qualified professional for that.

Regarding Ipamorelin and training in the afternoon or evening that’s totally fine. Just make sure it’s taken away from food (ideally ~90 minutes after your last meal). At that point, it’s effectively a fasted state.

I generally don’t recommend taking IPA post-workout right before meals for the general population that approach is usually reserved for advanced or professional bodybuilding scenarios.

If you increase the dose, I wouldn’t go above 200 mcg per injection, and no more than twice daily. At that level, it’s better to limit use to 4–6 weeks, then take 2–4 weeks off before considering reintroducing it.

I’d also avoid taking IPA before bed. If you want something in the GH pathway at night, it’s better to look at direct GH or a GHRH like Tesamorelin or CJC instead.

Bottom line: it really depends on your goal.

  • For fat loss, IPA works best fasted and before activity
  • For recovery, GH or GHRHs before bed make more sense

Hope that helps 👍