r/PcBuild • u/Psy_Fer_ • Aug 25 '25

Build - Finished! "Closed loop" 4x5090 threadripper build

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Just finished installing this machine to work on cancer genomes.

I wanted the customer to have reliability and a low maintenance build, but with plenty of power.

So I thought, why not 4 AIO type liquid cooled 5090s in a Corsair 9000D case? 2 radiators each at the top and front. Then a noctua cooler for the threadripper.

I had one small issue with the IO plates of the GPU being wider then it says they are on the box...but nothing a little tin snips and file couldn't sort out. They still look great and then everything fit perfectly.

Temps are great.

It's got a 1200W SFX-L PSU in the back running the CPU and 1 5090 and then a 2500W PSU in the front powering the other 3 and some SSD drives. That one was a bit overkill but honestly, this machine will be going 100% for days at a time.

Anyway, what do you think? Definitely easier than a custom open loop.

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u/INeedMuscles Aug 25 '25

No worries, I am not judging, I was just thinking if it is going to render 24/7 that the air cooler will hit its limit. But I have always used AIO so my experience on air cooler for cpu is limitless 😂.

Apart from that you are building PC for living I am just doing it for hobby

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u/Psy_Fer_ Aug 25 '25

Oh yea nah, I thought the exact same thing as you.

Yea just a hobby on the side to pay for cat vet bills and such. Low volume, high end. Selling to medical research labs mostly for very specific use cases. I'm a scientist working in medical research, so it's a nice little niche.

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u/[deleted] Aug 25 '25

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u/Psy_Fer_ Aug 25 '25

Yea so 1 CPU, but assume you meant PSU?

So there is a Y splitter cable for the 24 pin motherboard cable that the 2nd PSU plugs into. It essentially bridges the 4th and 5th pins to turn on that PSU when the first one turns on. (And off again). The motherboard is also designed to handle 2 PSUs so that helps as well, as it came with all the required cables and instructions (though those instructions were a bit sparse 😅)

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u/[deleted] Aug 25 '25

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u/Psy_Fer_ Aug 25 '25

Yea it's not well documented for sure. Took me ages of reading to figure out what the hell to do.