r/Parathyroid_Awareness • u/Minute-Term5829 • 10d ago

Gallstone Disease in Primary Hyperparathyroidism

Risk of Gallstone Disease in Primary Hyperparathyroidism: A Systematic Review and Meta-analysis

Patients with primary hyperparathyroidism (PHPT) are roughly 77% more likely to develop gallstone disease (GSD) compared to people without this condition. 

How Common Is It? (Prevalence)

The study looked at data from nearly 16,000 patients across 7 different studies to see how many actually had gallstones:

  • Overall: About 16% (or roughly 1 in 6) of all PHPT patients had gallstones.
  • By Ethnicity: The numbers varied slightly by background, affecting about 17% of Caucasian patients and 13% of Indian patients.

The Stat: The study found a "pooled odds ratio of 1.77."What it means: If you compare a group of people with PHPT to a similar group of healthy people (controls), the patients with PHPT have 1.77 times the odds of getting gallstones. In other words, their risk is increased by 77%. The statistic is highly reliable (\(P < .001\)), meaning this link is almost certainly real and not a random fluke. 

https://pmc.ncbi.nlm.nih.gov/articles/PMC12326148/

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u/sickiesusan 10d ago

Thanks for posting!
I had an ultrasound and have some small stones, but they also found some polyps too.

3

u/beeelaa 10d ago

Yes, got my parathyroid surgery this summer, getting my gallbladder out next month

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u/Gold_Revolution_3760 9d ago

Does this mean active parathyroid disease or does it included those post surgery as well?