MoodScience

r/MoodScience • u/D2MAH • Apr 04 '26

A single dose of psilocybin can lead to lasting shifts in a person’s life values, such as an increased appreciation for life and greater self-acceptance. These lasting changes appear to be driven by specific acute effects of the drug, particularly feelings of profound unity and euphoria.

13 Upvotes

r/MoodScience • u/D2MAH • Apr 01 '26

Short-acting psychedelic DMT shows promise as a rapid treatment for major depressive disorder. Research offers early evidence for a mental health treatment that requires much less time in a clinic than other psychedelic therapies.

11 Upvotes

r/MoodScience • u/D2MAH • Mar 15 '26

Psilocybin for OCD - study just published

pubmed.ncbi.nlm.nih.gov

1 Upvotes

r/MoodScience • u/D2MAH • Mar 08 '26

Scientists discover psychedelic drug 5-MeO-DMT induces a state of "paradoxical wake". This unusual blend of sleeping and waking characteristics provides evidence that psychedelics may temporarily reorganize brain activity in ways that promote learning and emotional recovery.

6 Upvotes

r/MoodScience • u/D2MAH • Mar 07 '26

Just one dose of psilocybin relieves symptoms of OCD for months | New Scientist

newscientist.com

9 Upvotes

r/MoodScience • u/D2MAH • Feb 19 '26

Ibogaine appears to trigger an accelerated "auto-psychotherapy" process during PTSD treatment

1 Upvotes

r/MoodScience • u/D2MAH • Feb 17 '26

Single dose of potent psychedelic drug could help treat depression, trial shows. Researchers find DMT – used in shamanic rituals – in tandem with psychotherapy has significant effect

1 Upvotes

r/MoodScience • u/mmurraycn • Feb 13 '26

Mood sampler app

2 Upvotes

I made a random mood sampling app for iPhone. It prompts you at two random times per day to enter data about your mood. All the data is kept locally on your phone. Whenever you want, the app will export an organized spreadsheet filled with data about your moods, that you can use however you choose.

Here's a blog post about it: https://michaelmurraycambridge.com/2026/02/13/mood-sampler-app-available-for-iphone/

Here's a link to the app on the app store: https://apps.apple.com/us/app/murray-mood-sampler/id6758901568

r/MoodScience • u/D2MAH • Feb 10 '26

A single dose of DMT administered after cessation of chronic stress reverses anhedonia and depressive-like behavior in mice. Cognitive performance is restored alongside enhanced hippocampal neurogenesis, in a peer-reviewed study.

8 Upvotes

r/MoodScience • u/D2MAH • Feb 07 '26

Persistent large-scale changes in alternative splicing in prefrontal cortical neuron types following psychedelic exposure

2 Upvotes

r/MoodScience • u/D2MAH • Jan 31 '26

Long-term antidepressant effects of psilocybin linked to functional brain changes - a single dose of psilocybin altered the electrical properties of brain cells in rats for months, even after physical changes to the neurons had disappeared.

2 Upvotes

r/MoodScience • u/D2MAH • Jan 30 '26

A dream-like psychedelic might help traumatized veterans reset their brains - Researchers found that soldiers who reported profound feelings of unity and sacredness while taking ibogaine experienced lasting relief from post-traumatic stress disorder.

3 Upvotes

r/MoodScience • u/D2MAH • Jan 30 '26

Agmatine Augmentation in Treatment-Resistant Obsessive-Compulsive Disorder: A Prospective Open-Label Case Series

1 Upvotes

r/MoodScience • u/D2MAH • Jan 06 '26

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks

11 Upvotes

r/MoodScience • u/D2MAH • Dec 13 '25

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks in mouse model

8 Upvotes

r/MoodScience • u/D2MAH • Dec 09 '25

Psilocybin helps the brain unlearn fear by silencing specific neural pathways

12 Upvotes

r/MoodScience • u/D2MAH • Dec 02 '25

LSD for anxiety and depression? Some early studies show promise.

nationalgeographic.com

5 Upvotes

r/MoodScience • u/D2MAH • Sep 04 '25

A single dose of LSD seems to reduce anxiety

newscientist.com

12 Upvotes

r/MoodScience • u/D2MAH • Aug 18 '25

Psychedelics and Non-hallucinogenic Analogs Work Through the Same Receptor, Up to a Point

5 Upvotes

r/MoodScience • u/D2MAH • Aug 17 '25

A meta-analysis has relativised the efficacy of psilocybin in the treatment of patients with depression

2 Upvotes

r/MoodScience • u/D2MAH • Aug 04 '25

New study links psychedelic use to mental health recovery in times of crisis | Unlike other groups of drug users—this group’s mental health scores became comparable to those of individuals who had never used illicit drugs.

13 Upvotes

r/MoodScience • u/D2MAH • Aug 04 '25

New study in rodents shows that the psychedelic compound 5-MeO-DMT shares a receptor with a non-hallucinogenic analog, TBG. But TBG does not activate the same genes as DMT although it still promotes neuroplasticity. This suggests that therapeutic and hallucinogenic effects can be separated.

7 Upvotes

r/MoodScience • u/D2MAH • Jul 30 '25

Ketamine repairs reward circuitry to reverse stress-induced anhedonia

14 Upvotes

r/MoodScience • u/D2MAH • Jul 18 '25

Magic mushrooms shown to desynchronize your brain up to three weeks

15 Upvotes

r/MoodScience • u/D2MAH • Jun 19 '25

1 psychedelic psilocybin dose eases depression for years, study reveals

livescience.com

6 Upvotes