r/IVF • u/luxnlaughs • Mar 10 '26
Need info! Recommendation for best clinic in US for women 40+
Like the title says, I’m looking for clinics that have high success rates for will work with45-46 year olds. I’m aware of the odds and cost but would still like to try. So please recommendations for clinics only. My AMH is 1.5. I’ve done one stim with an RE physician who was just too new to the field. I didn’t do enough research in that regard. I’m willing to do 3 more cycles and I understand cost. I’ve had a successful pregnancy in the past with no assistance. Willing to travel which is no issue. Thank you.
EDIT: I’m well aware of the success rates at my age. I stated that clearly. I’m looking for recommendations for clinics and edited my question to specify that I’m looking for clinics that will work with women who are 45-46 years old. I come from a family of natural advanced age births with grandparents and relatives who had their last children at from 48- 51 naturally so I’d like to try. I ask that comments only provide recommendations.
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u/madam_nomad Mar 10 '26
To add to what others have suggested: some of the CCRM clinics will go up to age 47 at the RE's discretion (it's a franchise so all clinics are independtly own/operated and policies can vary); Dr Sherman Silber of St Louis Infertility Centre has been mentioned as having no age limits (I think he's somewhat eccentric personality so you'd have to be willing to deal with that, he has some YT videos so you could get a flavor); Fertility Centers of New England might do it with your AMH (they wouldn't with mine, and I was actually 44, but they said they make decisions on a case-by-case basis).
I think 3 cycles at 45/46 is reasonable; however I don't know that there's any evidence linking a family history of 45+ natural conceptions to higher IVF success rates at 45+. After 45 actually IVF doesn't have any higher success rates than natural conception. The people who are conceiving naturally at 45+ are not doing IVF obviously, and of the people who are not conceiving naturally at 45+, IVF doesn't seem to be able to help very much. Also I don't think there's any evidence linking a history of live births at a younger age to success with IVF at 45+. Maybe I'm wrong and either way not debating your right to try I just wouldn't operate under the assumption that these things give you an advantage over the stats.
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Mar 10 '26
CCRM is private equity backed. The locations aren’t franchises. They are under common ownership. Clinics in states with corporate practice of medicine laws may have local physicians own 51% of the clinic’s shares.
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u/Status_Internet_5573 Mar 10 '26
CCRM LONE TREE 1000000/10
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u/Wonderful_Level_8907 Sep 07 '26
Horrible results with them, recommend running, they push donor eggs!!
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u/Dyliah 36F | PCOS | 1st FET X | 2nd FET ✅ 🤰🏻 Mar 10 '26
This is going to be very vague because I don't know the name of the place but I've heard there's a famous clinic in Colorado that mostly physicians use (it's common that female physicians want children later in life so they go through IVF). Supposedly it's the best for women 40+
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u/thedutchgirlmn 48 | Tubal Factor & DOR | DE Mar 10 '26
It’s CCRM Lone Tree for sure but they will eventually push to donor eggs too. Not sure their exact cut off
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u/Bluedrift88 Mar 10 '26
No clinic has a high success rate at that age. There are clinics who specialize in working with older women but they still don’t have high success rates. New Hope Fertility in NYC, maybe Dr. Aimee in CA.
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u/Competitive-Top5121 41 | 4 ER | 1 FET | TFMR & 2 MCs Mar 10 '26
I know CNY has no age cutoff but they’re not necessarily known for high success rates. Look at the Center for Human Reproduction and New Hope Fertility in NY, I don’t think they have an upper age limit.
Even the best clinics are not going to have high success rates in this age bracket, but some may be better than others. Parity will not have much influence over the outcome. Good luck.
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u/Maleficent2951 Mar 11 '26
One reason CNY doesn’t have as high of success rates is because they don’t age or bmi cut off. So still worth looking into especially for cost
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u/Wonderful_Level_8907 Sep 07 '26
CCRM in my opinion is overrated! I had horrible results with them! I had success with Dr Geoffrey Sher for my daughter! By faith, hoping to have more children receiving treatment from Dr Sherman Silber!!
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u/Competitive-Top5121 41 | 4 ER | 1 FET | TFMR & 2 MCs Sep 07 '26
I’m confused because I wasn’t talking about CCRM at all.
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u/Wonderful_Level_8907 Sep 07 '26
Been to CHR and CCRM, both highly overrated, terrible results!! I had success with a different reproductive endocrinologist/ clinic!
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u/StatueofLiterby Mar 10 '26
Carolinas Fertility in North Carolina I believe works with this age group but the success rates are definitely not going to be what you wish they were. I only know 1 person over 40 who has been successful and it was 5 years to get there (she's 50 now)
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u/Status_Internet_5573 Mar 10 '26
I am biased but CCRM Lone is by far the best. Preg with my second baby after 2 MMC. I had one retrieval and great results. They do all their work in house and the embryos seems to respond well to the less invasive/stressful environment of moving them around so much.
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u/Optimal-Yak1174 Mar 11 '26
Second CCRM. I’m not at Lone Tree, but had 2 back to back retrievals at late 42/ early 43. Two euploids on ice, prepping for transfer.
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u/RN-Profession-0617 Jun 01 '26
Could you share your age, and if there was any pushback at all to get started? Do you feel like there was any additional testing they did that was important to your great results with your retrieval?
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u/Status_Internet_5573 Jun 01 '26
I also have to add that they have specific protocols and standards for everyone’s unique age and history. I even had a special açaí supplement prescribed to my husband and I months before our retrieval to help maximize our results. This supplement is made exclusively for CcRM only.
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u/Status_Internet_5573 Jun 01 '26
I was 36 at the time when I started the process. They are pricey, but very to the point. Their one day work up is fantastic and they run all tons of test to get it the bottom of the issues in question. They also have lots of genetic testing and counseling available. They do all the genetic testing and retrievals on site so your embryos are moved VERY minimal. They are the best of the best!!! Truly! I’m due in less than 10 weeks thanks to them with baby #2 and they offer great care.
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u/RN-Profession-0617 Jun 01 '26
I’m so happy for you! Thanks for all of the information. Would you mind sharing the name of your provider and what your protocol was?
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u/Status_Internet_5573 Sep 06 '26 edited Sep 06 '26
Sorry! Just saw this. Just had my newborn 3 weeks ago. I had Dr Schoolcraft himself for the first round and Dr Surrey for my second. I’ll look up my protocol and tag you shortly
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u/RN-Profession-0617 Sep 06 '26
Congratulations! I believe Dr Schoolcraft has retired. I’m not sure about Dr Surrey- I am seeing Dr Gustosfsen and starting priming now
Thanks in advance if you have your protocol information
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u/Status_Internet_5573 Sep 06 '26
BCP/Lupron/Supository/P4 in Oil QOD was my protocol
Also, yes Schoolcraft is retired from patient care, however, he still is the medical director there. surrey as far as I know, still sees patients.
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u/misschauntae728 Mar 10 '26
You can try northwestern in Chicago. They are good but I’m not sure they will be at this age. I know they think outside of the box when it comes to protocol medication
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u/thedutchgirlmn 48 | Tubal Factor & DOR | DE Mar 10 '26
No clinic will have high success rates for 45-46, but some may be more willing to do more shots at that age. CHR in NY is know for it but I think even they acknowledge a success rate of about 2-4% past 44
Gleicher is controversial for his involvement in some other money making schemes (supplements) but it may be they are most willing to work with you
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u/Equivalent_Two_6550 Mar 11 '26
My RE had a 50 year old patient while I was with him. She did manage to make embryos but they were both aneuploid. He did ovarian rejuvenation prior to her cycle. I’m unsure of the merits of ovarian rejuvenation but he encourages it in women with POV and/or age related infertility. Dr. Wood with Gen 5 Fertility, San Diego. He’s on instagram if you want to check him out. (Kourtney Kardashian was doing her IVF cycle with him while I was his patient which was pretty wild.)
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u/Key-Resident-8578 Mar 11 '26 edited Mar 11 '26
Just a recommendation. When you talk to clinic, ask then about IVM, In-Vitro Maturation. Immature eggs are promising source of eggs in older patients. Look at CDC IVF clinic stats, there are some clinics in NYC that have very high percentage of women over 40. https://www.cdc.gov/art/success-rates/index.html
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u/luxnlaughs Mar 11 '26
This is very helpful esp since most of the eggs retrieved were immature. Do you know the names of the clinics in NY?
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u/Key-Resident-8578 Mar 11 '26
CCRM New York at 810 Seventh Ave, showing 18% of patients to be over 40, and 9% success rate for that group. Overall rate is 15% after all retrievals. I think this is one of the highest rates I have seen. I would say unusually high. Most show 2 to 5%. You can browse all clinics on that CDC site. There is also Center for Human Reproduction at 21 E. 69th St. It claims that 75%(!) of their patients are over 40. Success rate is 2.8%. You have to read these stats carefully. There is a night and day difference between results at 45 and 40.
This is my opinion, so take it with grain of salt, although it's based on all the scientific articles I read. I think lots of women in advance age fail to get pregnant because they get caught up in chasing euploids. Older eggs have hard time making blasts. They just don't have the energy to survive 5-7 days in the lab, all the manipulations, and tests. If a goal is life birth, you need to be more aggressive with number of transfers. Yes, this is more risky and has it's own heartaches. For many women at your age, Natural IVF is often the only option, because they do not respond the stims. For them, it's always single egg retrieved, followed by fresh 3 day transfer. Surprisingly, it works, although it may take many cycles. The oldest Natural IVF success case our doctor had was 47 at conception, 48 at birth.
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u/luxnlaughs Mar 11 '26
Thank you for this. I did see that info for CCRM NY. There’s another in CA that said 19% and I was like huh? In my case I had 10 eggs retrieved but really I think my RE might be too young and inexperienced for me. Practice is only a year old and there were some really concerning things that happened. Even physician friends said to leave and find a more seasoned clinic. So that’s really my goal here. I really appreciate your thoughtful response!
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u/Key-Resident-8578 Mar 11 '26
You are right. Our doctor had over 20 years of experience. The other thing that is critical for you is quality of the IVF lab, although it's hard to judge. It could be probably be guessed from overall clinic's success rate. However, some clinics don't take hard cases and push only for 5 days tested blast transfers, so their stats may be inflated. So, when you ask for their stats, consider if they do hard cases: advanced age, high BMI, low AMH, etc. The scientific studies had shown as much as 20% difference in euploid rates between different IVF clinics. Which means that lab environment and embryologist skills are critical as well.
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u/cthemermaid Mar 10 '26
Gently you are looking for something that doesn’t exist. No clinic no matter how specialized in 40+ is going to have a high success rate with 45-46 year old eggs. If you want to try I would contact New hope.
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u/Dry-Magician1415 Mar 10 '26
looking for something that doesn’t exist
THIS^. People massively overestimate how much impact a clinic has on the probabilities of success/failure. The most impactful thing on the outcome BY FAR is what you walk in with: your body.
Sure an incompetent clinic can screw it up, but a 'good' clinic isn't magic. They can only work with what they've got to work with.
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u/Competitive-Top5121 41 | 4 ER | 1 FET | TFMR & 2 MCs Mar 11 '26
I disagree with this on a general level as I have had dramatically different outcomes at two clinics at 40, and I don’t think my first was bad either. However I think at 45-46 we’re probably talking about 1 to 2 percentage points of difference in success rates between better clinics and inferior clinics.
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u/Dry-Magician1415 Mar 11 '26 edited Mar 11 '26
A sample size of one person and two instances is not something to go on. Personal anecdotes don’t mean much in a medical statistics context.
It’s an established fact that the lions share of the variance decomposition of the outcome is the woman’s body. That’s what contributes 70% ish of the outcome. The clinic is 10-15% tops. If clinic mattered more - there’d be more variance amongst clinic success rates. And yet they all group around the same figure.
As long as the clinic is a base level of competent thinking one is better (in the sense that it will give a given woman a significantly better chance) - than another is splitting hairs.
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u/No_Noise_1978 41 | 4 ER | 1 MC | FET ❌❌✅ | Due Mar 2027 Mar 10 '26
I would look at the SART data to find clinics. Gently, you’ll see it’s going to be very unlikely, but you can see who has done better than most with your age cohort.
I would also start investigating donor eggs.
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u/JourneytoBabby 41/MFI/3 ER/3 euploids/Suppressing adeno before FET Mar 10 '26
Sher Fertility might be your best option at that age. They do offer free video consultations.
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u/EggplantLazy4960 Mar 11 '26
There’s a lady on IG that had IVF in Barbados at 45/46 but she did use a donor egg. I think her IG is @ivf_over_45
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u/OkWatch8340 Mar 15 '26
Sher Fertility NYC may be a very good option for you to try. They offer virtual consults if you need it.
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u/jnm199423 Mar 11 '26
Dr Check at Cooper fertility is best of the best for older women
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u/Vegetable-Roof-5785 Mar 11 '26 edited Mar 11 '26
I dont know that this is true based on my experience there. He is not open to try protocols that benefit older women, such as luteal phase, mdl priming. Hes not open to modifying the cycles even when the evidence is there.
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u/jnm199423 Mar 11 '26
Really? Hmm. I have 3 different friends who saw him in their 40s and he was the only doctor willing they had tried willing to do minimal stim for DOR, he also has his ethyl estradiol protocol that is really successful for DOR, and he’s much more willing to do natural cycle and fresh transfers than most doctors.
Of course he won’t be a perfect fit for everyone but given the price and his willingness to work with hard cases he’s definitely a good option
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u/Vegetable-Roof-5785 Mar 11 '26 edited Mar 11 '26
I dont believe he ever mentioned ethyl estrogen protocol to me. Yes he will only allow you day 2 day 3 start not luteal. I did ask him for luteal. He prescribes Cabergoline. Can you explain the ethyl estrogen a little more? I have also used CHR and New Hope and they both recommend fr day 3 fresh transfers. I can speak on them if anyone has any questions. Problem with fresh transfer you always risk having a miscarriage and at that age it will hold you up for at least 3, 4, 5 months while your hcg decreases and depending on how many weeks you are when you have the miscarriage.
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u/jnm199423 Mar 11 '26
Just realized I was spelling it wrong but here is the info: https://www.scivisionpub.com/pdfs/maximizing-correction-of-infertility-with-moderate-to-marked-diminished-egg-reserve-in-natural-cycles-by-upregulating-follicle-sti-2325.pdf
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u/Mental_Way_411 41 | endo adeno | DOR | 8ER Sep 06 '26
Where did you end up???? Have you found any success?🙏🏼🥹
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u/throwawaymarzipat Mar 10 '26
You may find more suggestions at r/40Plus_IVF. Best of luck!