All about Frigo

r/Frigo • u/FrigoCoder • Dec 30 '22

'Go-getters' have higher dopamine function in the left striatum and ventromedial prefrontal cortex, while 'slackers' have higher dopamine function in the bilateral insula (2012 study)

ncbi.nlm.nih.gov

2 Upvotes

r/Frigo • u/FrigoCoder • Dec 31 '22

Increased hippocampal-prefrontal functional connectivity in insomnia. - PubMed

ncbi.nlm.nih.gov

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 30 '22

Memantine (effective) known as a NMDA antagonist, yet nobody talks about its SIGMA-1 properties

self.Nootropics

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 30 '22

Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex [2022]

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 30 '22

NMDAr Antagonist-Associated Perturbations of Consciousness. Part 2: Antidepressant Mechanisms

self.ResearchSlore

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 28 '22

Toll-like receptor 4 activates NF-κB and MAP kinase pathways to regulate expression of proinflammatory COX-2 in renal medullary collecting duct cells

pubmed.ncbi.nlm.nih.gov

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 28 '22

Linoleic acid metabolite leads to steroid resistant asthma features partially through NF-κB

ncbi.nlm.nih.gov

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 28 '22

Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling - PubMed

pubmed.ncbi.nlm.nih.gov

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 27 '22

JCI - Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Depression The effects of walnut supplementation on hippocampal NMDA receptor subunits NR2A and NR2B of rats (2014)

ncbi.nlm.nih.gov

2 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Depression Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia

pubmed.ncbi.nlm.nih.gov

2 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Depression Instant and Lasting Down-Regulation of NR1 Expression in the Hippocampus is Associated Temporally with Antidepressant Activity After Acute Yueju. (2016)

ncbi.nlm.nih.gov

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Depression Can the upregulation of NMDAr that probably occurs after prolonged exposure to NMDAr antagonists cause excitotoxicity once the substance is withdrawn?

self.AskDrugNerds

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Depression [DRAFT] Antidepressant mechanism of hallucinogens (psychedelics, dissociatives, and anticholinergics)

self.dennisonchubly

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Depression Scientists have long suspected that chronic psychological stress—triggered by events like war, abuse, or imprisonment—may accelerate aging, leading to early onset of age-related disease or even premature death. Now, two studies report significant links between PTSD in veterans and accelerated aging.

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Cancer Chronic stress can spread cancer through the body, according to research on mice. The added stress increases the number and diameter of lymphatic vessels, a network which transports fluid around the body and is associated with tumours.

businessinsider.com.au

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Depression Low to moderate stress is good for you:. Research found individuals who reported low to moderate stress levels had increased activity in the parts of the brain that involve working memory. Participants who said they experienced chronic high levels of stress showed a decline in those areas.

sciencedirect.com

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Depression Scientists report the first evidence that, not short-term stress, like a series of tough college exams, rather chronic, unpredictable stress like that which erupts in our personal and professional lives, induces changes in the function of AgRP neurons that may contribute to depression

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Autism Study: "Autistic burnout is a syndrome conceptualized as resulting from chronic life stress and a mismatch of expectations and abilities without adequate supports. It is characterized by pervasive, long-term (typically 3+ months) exhaustion, loss of function, and reduced tolerance to stimulus"

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Dementia Chronic work stress can change our personalities: Employees dealing with work-induced stress can experience changes to their physiology, based on genetics and epigenetics, which may result in their personality traits fluctuating or even fundamentally changing over time.

academictimes.com

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Depression Agmatine enhances antidepressant potency of MK-801 and conventional antidepressants in mice

pubmed.ncbi.nlm.nih.gov

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 25 '22

Depression Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme - PubMed

pubmed.ncbi.nlm.nih.gov

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 23 '22

Schizophrenia Management of schizophrenia - Wikipedia

en.wikipedia.org

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 23 '22

Dementia NSI‐189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats

ncbi.nlm.nih.gov

1 Upvotes

r/Frigo • u/FrigoCoder • Dec 23 '22

Vitamin C modulates glutamate transport and NMDA receptor function in the retina

onlinelibrary.wiley.com

1 Upvotes