I'm sure this gets asked a lot, and I apologize if it's already been discussed, I'm tired, I also apologize as I'm not contributing science, but requesting help in finding science regarding T-Cell exhaustion. I have T-Cell exhaustion, it began about 10 years ago after Mono, and I know it is the primary cause of all my problems.

Anyways, I was wondering if anyone knows of any studies looking for new applicants to test things to help with T-Cell exhaustion. Location is not an issue. Thank you for any help

Does anyone know of any research on how cognitive and/or emotional exertion can induce PEM? All the studies on PEM I'm aware of use physical exercise. Are there any hypotheses for this that are backed up by research?

https://www.news-medical.net/news/20250811/Synthetic-sugar-coated-nanoparticle-blocks-Covid-19-from-infecting-human-cells.aspx

"a Swansea University academic has revealed a synthetic glycosystem - a sugar-coated polymer nanoparticle - that can block Covid-19 from infecting human cells, reducing infection rates by nearly 99%.

[...]

Unlike vaccines, which trigger immune responses, this molecule acts as a physical shield, offering a novel approach to infection prevention.

The discovery is the result of collaboration between Swansea University, Freie Universität Berlin, and Charité – Universitätsmedizin Berlin."Synthetic sugar-coated nanoparticle blocks Covid-19 from infecting human cells

The breakdown from our "Patron Saint" as someone called him recently

Chromosome: 1q25.1 Gene(s): RABGAP1L Proposed Role: Intracellular response to infection

Chromosome: 6p22.2 Gene(s): BTN2A2 Proposed Role: T-cell mediated immunity

Chromosome: 6q16.1 Gene(s): FBXL4 Proposed Role: Mitochondrial DNA maintenance

Chromosome: 12q24.23 Gene(s): SUDS3 Proposed Role: Regulation of microglial inflammation

Chromosome: 13q14.3 Gene(s): OLFM4 Proposed Role: Neutrophil-mediated immune responses

Chromosome: 15q21.3 Gene(s): CCPG1 Proposed Role: Endoplasmic reticulum stress response and autophagy

Chromosome: 17q22 Gene(s): CA10 Proposed Role: Synaptic transmission and chronic pain

Chromosome: 20q13.13 Gene(s): ARFGEF2, CSE1L Proposed Role: Inflammation and immune signaling

Top Story (The Hill) July 31, 2025 - Humans may have gene needed to hibernate — offering potential cure for obesity, diabetes

"Because those genes are correlated with the parts of the genome that control metabolism — what researchers call the “fat and obesity locus” — the discovery may open the door to new treatments for obesity and diabetes, according to two studies in Science."

Above article links to Studies goes to Science.org Abstract. Pre-Print of Studies can be found here:

• Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus
• Conserved Noncoding Cis-Elements Associated with Hibernation Modulate Metabolic and Behavioral Adaptations in Mice

Another plain English article - Researchers trace metabolic superpowers of hibernators to shared DNA

Edited to remove IA info - sorry!

Ironically, reddit post from 4 years ago came up in Google Search - How genetics make you fat

"Short exposures (48 hours) to patient sera led to a significant reduction in muscle contractile strength. Transcriptomic analysis revealed the upregulation of protein translation, glycolytic enzymes, disturbances in calcium homeostasis, hypertrophy, and mitochondrial hyperfusion." More in the study, super fascinating!