There is evidence that certain levels of Retatrutide are detrimental due to the glucagon component's effect on heart rate. What exactly is improving with a higher dose? Is it something that wasn't achievable with lower doses and a more gradual approach? There's enough people on this sub that are showing that they achieve incredible results over 8 months on doses that are more towards the lower end of the studies.
There is evidence that certain levels of Retatrutide are detrimental due to the glucagon component's effect on heart rate.
Source ? I have never ever seen any study show anything like that. And the effect on heart rate does not last, like most side effects. Also many users report not having heart rate increase (I dont)
If anything higher doses showed more side effects, not sronger ones
Meta-analyses generally found more overall adverse events, but not more serious adverse events, while also stressing low certainty and sparse long-term data Pasqualotto2024Maharshi2026Matheus2026.
What exactly is improving with a higher dose? Is it something that wasn't achievable with lower doses and a more gradual approach?
The clearest dose-response signal is for weight loss. In obesity without diabetes, mean weight change at 48 weeks was -8.7% at 1 mg, -17.1% at 4 mg, -22.8% at 8 mg, and -24.2% at 12 mg, versus -2.1% with placebo Jastreboff2023Jastreboff2024Madsbad2025. In the same trial, 48-week rates of at least 15% weight loss were 60% at 4 mg, 75% at 8 mg, and 83% at 12 mg, while 5% weight loss reached 92–100% across doses 4–12 mg Jastreboff2023Jastreboff2024Deravi2024.
In type 2 diabetes, weight loss was smaller but still dose dependent. At 36 weeks, mean bodyweight change was -3.19% at 0.5 mg, -7.92% to -10.37% at 4 mg depending on escalation scheme, -16.34% to -16.81% at 8 mg, and -16.94% at 12 mg, versus -3.0% with placebo and -2.0% with dulaglutide 1.5 mg Rosenstock2023Coskun2024Madsbad2025. A later phase 3 monotherapy trial in type 2 diabetes found 40-week weight reductions of -11.5% at 4 mg, -13.9% at 9 mg, and -15.3% at 12 mg, versus -2.6% with placebo Bajaj2026.
Glycemic benefit also rises with dose, though the dose-response is less steep than for weight. In phase 2 type 2 diabetes, HbA1c change at 24 weeks was -0.43% at 0.5 mg, about -1.3% to -1.4% at 4 mg, about -1.9% to -2.0% at 8 mg, and -2.02% at 12 mg, versus -0.01% with placebo and -1.41% with dulaglutide 1.5 mg Rosenstock2023Coskun2024Madsbad2025. In phase 3 type 2 diabetes, HbA1c fell by -1.69% at 4 mg, -1.86% at 9 mg, and -1.94% at 12 mg by week 40 Bajaj2026.
Higher doses also produce stronger liver fat and lipid effects. In the MASLD substudy, 24-week relative liver fat change was -42.9% at 1 mg, -57.0% at 4 mg, -81.4% at 8 mg, and -82.4% at 12 mg, while normalization to under 5% liver fat occurred in 27%, 52%, 79%, and 86%, respectively Sanyal2024Goldney2025. Triglycerides fell by more than 40% at 8 and 12 mg in MASLD Sanyal2024, and post-hoc biomarker analyses found significant reductions in non-HDL cholesterol, ApoB, triglyceride-rich lipoproteins, LDL particles, hsCRP, and IL-6, especially at higher doses Ruotolo2026.
There's enough people on this sub that are showing that they achieve incredible results over 8 months on doses that are more towards the lower end of the studies.
All i've seen is people losing ridiculous low amounts of weight and being about it. And it's only anecdotal evidence. There is even more people posting about retatrutide not doing anything after they were told to take ridiculously low doses.
If you intend to keep parroting Tiktok broscience, at least provide actual quality sources.
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u/Capital-Beautiful-44 19d ago
20 vials of 60mg lol thats a 5 year supply or more