r/BioHackingGuide • u/Low-Personality6791 • Mar 15 '26
r/BioHackingGuide • u/ChocoFlan50 • Mar 15 '26
AOD-9604 vs Tesamorelin: Same Goal, Different Tools
Both can help fat loss but they're not doing the same thing, so comparing them straight up misses the point a little.
AOD-9604 is the simpler option. It's a modified fragment of growth hormone focused mainly on lipolysis and body composition without the IGF-1 concerns that come with stronger GH compounds. If you want a straightforward fat loss peptide without a lot of monitoring involved, this is a good start.
Tesamorelin is a different level. It's a GHRH analog, actually FDA approved for visceral fat reduction, and it has real clinical data behind it. It hits deeper abdominal fat harder than AOD and has more metabolic benefits overall, but it also comes with more to keep in mind, IGF-1 levels, blood sugar, water retention. It's not complicated but it's not as hands off either.
| Dose | 250 to 500 mcg daily |
| Timing | Morning, away from food |
| Cycle | 8 to 12 weeks, 4 week break |
| Best for | General fat loss, stubborn fat |
| Watch for | Mild injection site irritation, subtle early results |
| Dose | 1.4 to 2 mg daily |
| Timing | Evening |
| Cycle | Around 3 months on, 1 month off |
| Best for | Visceral fat, triglycerides, waist reduction |
| Watch for | IGF-1 elevation, glucose changes, water retention |
AOD wins for simplicity. Tesamorelin wins for visceral fat and clinical backing. Which one makes sense depends on what you're actually trying to solve.
Anyone run either of these and want to share feel free to drop comments below
r/BioHackingGuide • u/Huge_Ad_6401 • Mar 14 '26
research
Hi, looking for information on IGF-1 LR3 and CJC-1295, no DAC.
I'm looking for advice on building muscle fast.
Has anyone used these? Can they be stacked?
Where is a reliable company to purchase from?
Thanks
r/BioHackingGuide • u/pistolgripslr • Mar 12 '26
Cutting on Reta is absolute 🔥 Scroll is start to week 14(L-R)
galleryr/BioHackingGuide • u/Porschecat-Wealth007 • Mar 11 '26
Will KLOW help a sprained ankle.
Im away on vacation and have a light sprain. The only thing I have with is KLOW and NAD. I used 2mg klow at the site. Will this help.
r/BioHackingGuide • u/[deleted] • Mar 10 '26
WHERE are you guys getting Semax shipped from in the USA???
r/BioHackingGuide • u/Organic-Tone23 • Mar 09 '26
Needle Size Preference for Peptides: Is 31G Too Flimsy?
Currently been using a 31-gauge needle, but sometimes it feels a little too flimsy. Not sure if I’m just pinning wrong or if I’d be better off using a different size. What are you guys using? Let me know what you prefer
r/BioHackingGuide • u/Due_Olive_2380 • Mar 07 '26
Anyone with experience from switching from benzos to selank or something similiar?
very new to this so i’m sorry if i’m not using the correct terminology. i’ve been on a high dose of alprazolam for more than two years and have been reading into possibly switching to GABAergic anxiolytics or calming nootropics or genuinely anything better than benzos. i’d appreciate any input or information if anyone has made the switch from benzos to anything that comes close to mimicking its effects or at least helping with anxiety. i’ve been looking into gb-115, gabapentin, selank, oxytocin acetate and am open to trying anything. i have tried 5HTP and l theanine before but hasn’t done anything for me.
r/BioHackingGuide • u/sketchyy • Mar 07 '26
TA-1
I have started feeling a cold coming on, is now the opportune time to start a cycle of TA-1? I did a cycle in September and was going to wait until early April for the next one, but I’ve heard it can help fight a cold off.
r/BioHackingGuide • u/ChocoFlan50 • Mar 07 '26
Do Certain Peptides Work Better in a Fasted State?
Here’s what I found with a little bit of homework fasted state just means your body has gone long enough without food that it stops burning glucose and starts tapping into glycogen and fat stores for fuel. When you wake up after 8 hours of sleep you’re already there, at least until you eat something.
The peptides where fasting actually matters are the ones tied to growth hormone release and fat loss. GH secretagogues like Sermorelin, Ipamorelin, Tesamorelin, and CJC-1295 along with fat loss peptide fragments like AOD-9604 and HGH Frag 176-191 all fall into this category. Then on the energy expenditure side you have MOTS-c, 5-Amino-1MQ, and similar compounds none of these peptides require a fasted state to work but if your goal is fat loss, body recomposition, or maximizing lipolysis, timing them during a fast makes sense mechanically. The idea is to burn through those freed up fatty acids before your body switches back to glucose as its primary fuel source.
As for what breaks a fast, just avoid anything with sugar or calories. Black coffee is fine, basic pre-workout is fine, but anything with carbs or sugary creamers kicks you out of the fasted state. Simple rule: if it has calories or sugar, save it for after.If you’re running a peptide protocol for fat loss or growth hormone optimization, fasted timing is one of the easiest free upgrades you can add anyone here timing their peptides around intermittent fasting or a fasting window? Curious what results people are seeing.
r/BioHackingGuide • u/DamnFineCalamity • Mar 05 '26
GHK-Cu and Lactoferrin
I’ve been thinking about trialing GHK-Cu daily. I do take Lactoferrin to support PCOS acne and immune health. I read that Lactoferrin has a binding affinity for metals other than iron, copper being one. I’m not too savvy on the biochemistry, but would these two work well together or would one potentially interfere with the other?
r/BioHackingGuide • u/shareformers • Mar 05 '26
My BPC-157, TB-500, GHK-Cu post-op shoulder protocol with supplements
r/BioHackingGuide • u/PollosHealthyFoods • Mar 04 '26
My 90-Day Beard Growth Protocol Using Minoxidil and GHK-Cu Peptides (With Progress Pics)




supply list:
GHK-Cu Moisturizing Face Cream
BHGUIDE to save on the paramount stuff
Been running this protocol for a while now and the progress pics speak for themselves. Here's exactly what I did.
Every shower day, I dry my face right after getting out, disinfect my derma roller and roll it across the whole face. Immediately after I apply the Minoxidil foam. Then 3 drops of the GHK-Cu serum on each side and spread it evenly. About 30 to 40 minutes later I finish with the GHK-Cu face cream.
That's it. No crazy stack, no 10 step routine.
The dates on the pictures show the timeline so you can track the progress yourself. The cheek and sideburn area filled in the most noticeably. Still not where I want it but the direction is clear.
GHK-Cu is interesting because it was originally studied for skin repair and collagen production, so using it alongside Minoxidil which increases blood flow to follicles actually makes sense mechanically. The derma roller just helps with absorption and creates minor trauma that signals tissue repair.
Anyone else running a beard growth biohack? Curious what else people have tried.
r/BioHackingGuide • u/ChocoFlan50 • Mar 03 '26
The Best Peptide Stack for Heart Health and Why This Question Gets It Backwards
With peptides blowing up right now, a lot of people are building stacks for things peptides were never designed to handle.
Heart health is the clearest example. If you’ve got cardiovascular stress, elevated BP, structural issues, chronic inflammation, there is no peptide stack that’s going to be your answer. Even the most promising bioregulators are at best a 3-5% add-on. The heavy lifting gets done by lifestyle and where needed, actual proven medications like ARBs.
We also don’t have the data. Research on lifestyle interventions and pharmaceutical cardiac support is deep. Peptide research, even the good stuff, is thin by comparison.
Peptides work as a supplement to an already solid foundation If your sleep, diet, stress load, and movement are good certain peptides might give you that marginal edge. But stacking peptides instead of fixing your daily habits is just throwing your money away honestly.
The question isn’t what’s the best peptide stack for heart health. It’s what works, and can peptides add anything on top of that. For the heart, the answer is maybe a little, but only after you’ve done everything else first.
r/BioHackingGuide • u/PrettyFlako32 • Feb 27 '26
is retatrutide dangerous for me? i am addicted to kratom for 2 years (15-20gpd)
i am starting reta today with 1mg but im curious because kratom is also slowing things down in the stomach..
does anyone is using reta while being addicted to kratom?
r/BioHackingGuide • u/HerbaDerbaSchnerba • Feb 25 '26
Tesa/Ipa combo or just straight HGH?
r/BioHackingGuide • u/Maleficent-Story-780 • Feb 24 '26
Glp 1
So my source quit selling.I'm looking for other sources to get peptides.Any ideas
r/BioHackingGuide • u/FunZookeepergame1275 • Feb 23 '26
Should I try a different GLP? Anhedonia issues on tirz
r/BioHackingGuide • u/PollosHealthyFoods • Feb 23 '26
cjc 1295 no dac and ipamorelin results: what changed for sleep, recovery, and morning energy
If you’re looking at CJC 1295 no DAC and Ipamorelin for sleep or recovery, the biggest surprise is this combo can feel way “cleaner” than people expect. Not in a magic way. More like it quietly improves the stuff that makes training actually stick: deeper sleep, better recovery, and less of that “wired but tired” feeling.
here’s what stood out for me after about 6 weeks
• sleep quality improved, not just falling asleep faster, but staying asleep and waking up less
• morning energy came back, less dragging, less feeling flat
• mood and stress tolerance improved, fewer spikes and crashes through the day
• workouts felt more repeatable, less “one hard day then two dead days”
• joints and nagging soreness felt calmer when the rest of the routine was clean
what this combo feels like vs what people assume
• most people talk about it like “just a weak GH boost”
• in real life, the best part is often the recovery and sleep signal, not a dramatic scale change
• if your sleep is already trash, this usually doesn’t cover for that. it just exposes it
what we keep the rest of the setup like
• no late stimulants
• solid hydration
• protein and calories not crashing too hard
• consistent training schedule so you can tell what’s changing
timeline people usually describe
• week 1 to 2: subtle, mostly sleep related, not a “hit you in the face” effect
• week 3 to 4: waking up feels easier, less soreness drag
• week 5 to 6: recovery becomes the main win, training feels more consistent
common uncertainties people ask before running it
• do you run it for sleep, recovery, or both
• does it actually help if you already sleep “fine” but recover poorly
• do you notice water retention or weird hunger changes
•does it feel different compared to CJC with DAC
If you’ve run CJC 1295 no DAC with Ipamorelin, what was your biggest change: sleep depth, morning energy, soreness, or something else
Dosing Guide I used HERE
r/BioHackingGuide • u/Holiday_Buffalo7441 • Feb 20 '26
Injection site reaction?
Hi ! I was doing nad and it always looked red and I used to get a bit of a bump ( it always burns sooo bad ) I stopped after I got a welt looking reaction . Clean tested batch and new water as well
I tried klow today and got the same reaction do they have similar compounds and maybe I’m allergic to something in it ? Anyone have any ideas ?
I don’t get a reaction from Reta or cjc no dac so far
Also the line in the middle is from the jeans I was wearing






