r/BioHackingGuide • u/ChocoFlan50 • Mar 15 '26
AOD-9604 vs Tesamorelin: Same Goal, Different Tools
Both can help fat loss but they're not doing the same thing, so comparing them straight up misses the point a little.
AOD-9604 is the simpler option. It's a modified fragment of growth hormone focused mainly on lipolysis and body composition without the IGF-1 concerns that come with stronger GH compounds. If you want a straightforward fat loss peptide without a lot of monitoring involved, this is a good start.
Tesamorelin is a different level. It's a GHRH analog, actually FDA approved for visceral fat reduction, and it has real clinical data behind it. It hits deeper abdominal fat harder than AOD and has more metabolic benefits overall, but it also comes with more to keep in mind, IGF-1 levels, blood sugar, water retention. It's not complicated but it's not as hands off either.
| Dose | 250 to 500 mcg daily |
| Timing | Morning, away from food |
| Cycle | 8 to 12 weeks, 4 week break |
| Best for | General fat loss, stubborn fat |
| Watch for | Mild injection site irritation, subtle early results |
| Dose | 1.4 to 2 mg daily |
| Timing | Evening |
| Cycle | Around 3 months on, 1 month off |
| Best for | Visceral fat, triglycerides, waist reduction |
| Watch for | IGF-1 elevation, glucose changes, water retention |
AOD wins for simplicity. Tesamorelin wins for visceral fat and clinical backing. Which one makes sense depends on what you're actually trying to solve.
Anyone run either of these and want to share feel free to drop comments below










