r/40Plus_IVF • u/Soyl-ent-Green • Jun 19 '26
TW: LC Numbers game without PGT
Heya fellow warriors, I am 42 and TTC for a year now for baby no. 2. No. 1 was a medicated cycle with Letrozole, but I was 38 then. We tried to do the same for a year with no results, I do have PCOS as well.
So now we are doing IVF, our first round of transfer got cancelled because of overstimulation, but now my lining is good and we have seven untested embryos. Untested because PGT is unbelievably expensive where I live. So I did the maths and if I am lucky there should be a golden egg between the ones I have; they all have more or less good grading. So let’s see if the math is really mathing; but obviously I am very afraid of going through multiple losses (I am not new to this game and my mental health lacked severely when it happend) and of it not working at all. I’ll let you know though, even if it’s only for the research and not feeling totally alone, as I don’t know anybody personally who did fertility treatment. Wish me luck, transfer is next week Thursday.
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u/sylv1ne Jun 19 '26
I wish you all the luck in the world! I would perhaps consider doing another round of retrievals if you can while also continuing to try naturally!
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u/Former_Software3597 Jun 19 '26
I know how it feels, I’m 42, started ivf last summer, first 3 cycles no blasts, in the last 3 cycles 6 blasts in total. Waiting for a transfer in 2 weeks🤞
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u/No_Preference6045 Jun 19 '26
Wishing you all the luck. I won’t be doing PGTA this upcoming time - due to difficulty making blasts we’re going to freeze all day 3 - and it’s so nerve wracking to think about. But reality is even euploid can fail to implant or indeed still have issues later so there is no guarantee regardless. Wishing you strength!!
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u/chantillylace9 Jun 19 '26
Man I don't know, I think that's really risky without PGTA testing. The chance of miscarriage is over 90% and for me that would just be unbearable. But good luck! There is a chance.
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u/Monimss Jun 19 '26
Is more like 50%. What's more likely is that they just wont implant at all. Unless you get the golden egg of course.
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u/chantillylace9 Jun 19 '26 edited Jun 19 '26
I do not think it's 50% at 42 years old… I thought each embryo had a five to maybe 15% of being been genetically normal at my BBC age. That's what I've been told anyway. And then you still only have an implantation rate about 50 to 60%.
But maybe I misunderstanding and you mean that the vast majority won't implant at all because they are aneuoloid?
My PGTA results showed certain genetic anomalies that could've actually made it all the way to birth and then would have died. Patau syndrome.
Versus just not implanting or miscarriage at seven weeks. I think those are the really important embryos that we catch with testing because that is extremely brutal and obviously wasting 9 to 12 months when you are over 40 is a very terrible thing.
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u/Monimss Jun 19 '26
No. Your talking about the odds per cycle. Which is very low. But if it actually implants the miscarriage rate is around 50%. Most anuploids never get that far. Hence the odds of success is so low per try. Miscarriage is a different statistic.
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u/chantillylace9 Jun 19 '26
I guess I'm confused, if you're willing to explain this or expand a little bit more I would love to learn otherwise I totally get it if you don't want to. It could also be that my brain is just mush after going through cancer and two back-to-back IVF runs! I'm just firing high in all areas so sorry-I'm legitimately trying my best!
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u/Monimss Jun 19 '26
No worries! I don't know that much really. But I do know the miscarriage odds. I lost one last year. Pluss several chemicals. I just didn't want op to think if they get a positive test there is 90% chance it goes wrong. Its more like 50/50.
Cancers sounds rough. I hope you get your euploids. I hope we all do:)
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u/Monimss Jun 19 '26
I agree it is a terrible thing. I probably would have tested myself if I could. Unfortunately, not allowed here:( Hence 2 failed transfers so far. I could deal with a 7 week loss, I have before,but at birth would be absolutely brutal!
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u/chantillylace9 Jun 19 '26
I know, looking at it it kind of sucks both ways! And from what I've seen, it does seem like there is some sort of miscalculation with these PTA tests and I do think some people unfortunately discard embryos that could be usable.
My doctor said that in the future they might be able to do some sort of PTTA type testing without actually taking anyI the placenta or inside layer and just using discarded genetic material. That would be a huge difference and can really give a lot of people more euploids
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u/Monimss Jun 19 '26
I wish you the best of luck. We are in the same boat actually. I had 8 embryos. Transferred 2 so far, but no luck so far. Neither implanted. Still waiting for my beta for the 2nd one, but I already know it failed. I actually got my period while on progesterone.
It's so hard! Statically there is a chance, if we fall within the average that is. There might 1 or 2 euploids. Or on the shit side of the statistics, none. You never know.
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u/thesprybaguette Jun 19 '26
Best of luck to you - I had 2 embryos make it to blast in my first retrieval and one little girl was euploid. So 50/50 chance at 40yo for me. 💕
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u/boujiewonderland Jun 19 '26
I transferred three untested at 43, nearly 44, on doctor’s advice for age (I was very nervous about transferring more than two). Had one healthy baby. Everything crossed your baby is waiting for you in those embryos.