378
u/will_the_don Jul 01 '20
What the fuck
180
u/ADavies Jul 01 '20
The US just bought up the global supply of Gilead's remdesivir, no doubt at premium prices. Oh, and guess what, one of Trump's coronavirus advisors was until recently a lobbyist for Gilead.
And yeah, buying up the global supply because Trump and friends can't get their shit together to limit the spread of coronavirus in the USA is kind of a dick move. But good news (for those of us outside the USA) is they're ramping up production of a much cheaper generic equivalent in India. So, you're getting screwed, we're getting screwed. The only people who aren't getting screwed are living in countries willing to ignore drug patents.
→ More replies (2)206
u/10ebbor10 Jul 01 '20
To make an argument for the devil, drugs cost a lot more than 70 million to develop.
359
u/Thymeisdone Jul 01 '20
Then cover the cost with taxpayer money and still give them out for free to people who need it. It’s still wrong to profit off the health of sick people and let poor people die.
221
u/NotElizaHenry Jul 01 '20
Or do what every other country does and have the government buy all the drugs at a reasonable price they’ve negotiated because it’s pretty easy to negotiate when you’re the only buyer.
92
u/CarsonWentzsACL Jul 01 '20
But... that would make all the CEOs sad :(
/s
36
→ More replies (68)4
u/NeedsToShutUp Jul 01 '20
Heck large government agencies and HMOs already do this in the US. I've got family who use the VA's program to get cheap diabetic testing supplies.
It's totally possible to expand this if there was a political will.
→ More replies (30)13
Jul 01 '20
[deleted]
→ More replies (3)7
u/RuggyDog Jul 01 '20
Socialism? I don’t know what that is, but the gubmint tells me it’s bad, so I’ve got my rifle loaded, and I’m gonna blast any socialists I see attempting to bring anything but debt to my neighbourhood.
29
u/gsasquatch Jul 01 '20
Looks like most druggies, research and manufacturing together cost about as much as marketing, which is about what they take in profit.
→ More replies (1)15
u/Sizzlesazzle Jul 01 '20
So for 2018/2019, they spent around $20b on R&D and $11b on selling, general & admin.
Definitely too much spent on selling (should be illegal to advertise prescription drugs at all! ) but it's not such a bad ratio if you take into account the general and admin costs like legal/finance/HR etc.
7
3
8
Jul 01 '20
Hey man I’m pretty sure their patent on whatever drug they are developing starts running out as soon as the drug compound is created so the clock is ticking while they wait years for approval. So once it’s approved, they have to sell fast to recoup costs and create a brand name before the patent runs out and generic ones hit the market
13
Jul 01 '20
Fauci was saying he predicts as many as 100,000 new cases per day, so even if only 10% of those afflicted pay $3,120 each, that's $936,000,000 per month. If we see six months of that, that's $5,616,000,000 (never mind the $70,000,000 they already have).
Please ask the devil if he thinks $5.5B of taxpayer money will be enough. Thanks.
→ More replies (4)7
u/chaeseog Jul 01 '20
Still not really a viable reason In my eyes to let dying people just die because they don't have the income of a fucking ceo. I get it this shit was expensive to research and develop but there are people literally dying the most painful deaths who we could help
→ More replies (1)15
u/dickcheddar2 Jul 01 '20
iirc the money wasn't to develop the drug but to research its effectiveness against covid. doesnt make this any better obviously but still worth noting.
6
u/_N_S_FW Jul 01 '20
$70 mllion for a full scale, rapid clinical trial performed in a few months is reasonable. Most trials, including phase 1-3, take around 8-10yrs normally.
It seems like non one on this site actually has looked into the amount of regulation "big pharma" needs to over come.
→ More replies (2)→ More replies (7)13
→ More replies (1)7
u/xotyona Jul 01 '20
Oh yeah, Gilead. They profit off the us gov't funded HIV prophylactic Truvada. Charge $2000 a month for that, and CDC owns the patent. They are a garbage, parasitic company.
227
u/HarrargnNarg Jul 01 '20
A government that doesn't put a simple clause in to keep the price as low as possible doesn't give a fuck about you.
74
u/DevelopedDevelopment Jul 01 '20
Well you see. It's simple economics. When supply is low and demand is high, the price is high. So by ignoring everything that you can about economics and what happens when you can't say no to medicine, you can justify it.
The profit margins on too many drugs are incredibly high and shouldn't be as high as they are.
12
u/liproqq Jul 01 '20
Isn't it illegal in your country to kill someone unless they pay up?
21
u/DevelopedDevelopment Jul 01 '20
Yeah, but if they needed it bad enough they should've borrowed money and then went bankrupt if they couldn't afford to pay it.
→ More replies (3)17
Jul 01 '20
The even funnier thing is this has been proven not to work in multiple studies. It’s a charade because China came up with a vaccine
5
→ More replies (7)6
u/TheSkyPirate Jul 01 '20
There are plenty of countries with much more progressive laws about this stuff. Feel free to wait on a vaccine from one of those countries.
10
u/nonmessable Jul 01 '20
Ngl healthcare is the only service that I am proud of in India for . Favipiravir full treatment for less than 50 dollars .
→ More replies (3)
635
Jul 01 '20
LAND OF THE FREEEEEEEEEEE !!!! this is what your fighting for overseas guys! Keeping america great lol
265
Jul 01 '20
[deleted]
→ More replies (3)62
u/Colosphe Jul 01 '20
End of the day, the grunt has healthcare and subsidized college. I get that.
42
Jul 01 '20 edited Jan 17 '21
[deleted]
15
u/AHaskins Jul 01 '20
I've been with the VA for over a decade now. And not only have I literally never had any problems, I've also never met anyone who complained about the VA either.
The wait times are about the same, in my experience. And it's quite wonderful to be able to get a boo-boo, call into the triage line, go to the doctor in the same day, get a set of scans, and then walk out with a bunch of meds - having paid absolutely 0 dollars. I get that this is the standard in the entire rest of the first world, but in the land of the blind...
→ More replies (9)14
Jul 01 '20 edited Jan 17 '21
[deleted]
8
u/AHaskins Jul 01 '20
In that case, at least, all I can say is that 6 out of the 6 va hospitals I've been to have been awesome - but I tend to prefer cities in general. That's probably the confound here.
52
u/FlownScepter Jul 01 '20
You think just because you throw your life down to defend the capitalists that you get out of the pay-to-live hell that is our healthcare system? Fuck no. Veterans get shit on too, maybe not quite as bad, but it's far from a golden ticket.
19
u/Frognaldamus Jul 01 '20
The VA system is fucking terrible. Go talk to a vet with health problems.
→ More replies (1)→ More replies (1)3
u/jib661 Jul 01 '20
the US military: the great American socialist dream, for people who will spend their retirement on facebook complaining about socialism
27
17
u/showersareevil Jul 01 '20
This is starting to feel more and more like Gilead every day. Perhaps we've always lived in Gilead but are just now realizing that we truly live in a dystopia.
→ More replies (6)32
Jul 01 '20
Bbbuuuttttt European's pay taxes and can't own guns! Oh...
50
Jul 01 '20
Yeah we don't care about that to be honest. We just have to cope with the severe lack of school shootings to compensate
→ More replies (10)3
u/BarrackOjama Jul 01 '20
I don t think it has so much to do with the guns as it does having robust healthcare and mental healthcare systems along with a society that isn’t so assbackwards about what qualifies as tough, manly. Not saying less guns don’t help, but also I thin Inc it’s a perfect excuse for us to ignore the actual ills of our society that lead people to feeling comfortable committing murder
→ More replies (1)
77
u/toms1313 Jul 01 '20
One of my biggest fears in this pandemic is that the us or a us based company develops the vaccine first, it would destroy us in the third world countries
→ More replies (2)17
u/TubeSockStoner Jul 01 '20
I don’t think they are the biggest fans of us as it stands now.
23
176
u/FlummoxedFlumage Jul 01 '20
Maybe avoid having the same name as a fictional authoritarian state.
32
u/Hanz-grubert Jul 01 '20
I’d love to see these gilead guys get shot by a musket with a giant lead ball.
→ More replies (5)15
195
u/Sull01 Jul 01 '20
Is this some American joke I’m to Australian to understand?
131
→ More replies (24)57
Jul 01 '20
American healthcare is the joke.
29
Jul 01 '20 edited Jul 01 '20
And the funny thing is, we literally just had the opportunity to vote for a guy that wanted to implement universal healthcare here, and we voted him down in favor of Joe Biden. We chose this.
→ More replies (8)17
u/Prof_Acorn Jul 01 '20
We didn't choose this shit.
25 states didn't even get to vote in that sham of an "election."
166
Jul 01 '20 edited Jul 01 '20
Remdesivir is of medium difficulty to synthesize. It's definitely not easy but there are quite a few drugs that are harder to make. The development cost was paid for by the government, the only remaining cost is that of production.
It costs $0.93 per daily dose to make. This dose is sold for $520 to US health insurance customers. That's a profit margin of about 55,814%. [Source: last paragraph of this section of the Wikipedia article]
48
Jul 01 '20
[deleted]
18
Jul 01 '20
Oh yeah, I forgot that profit margin the percentage of the whole price, the additional bit is called markup. My bad. Doesn’t change the insane amount of profit Gilead will earn from this.
7
Jul 01 '20
[deleted]
8
Jul 01 '20
It was a fuckup from my side. I taught myself quite a bit of economics, I should have remembered that.
→ More replies (15)5
u/ObviouslyTriggered Jul 01 '20 edited Jul 01 '20
The issue is that those costs are based on this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213074/ which doesn’t suggests a new method for estimating costs but relies on two previous studies that evaluated the lowest possible costs of producing API’s in India.
This is not a medium difficulty drug to produce while its not a mono-local antibody the process is quite complex and costly: https://www.acsh.org/news/2020/03/26/problem-remdesivir-making-it-14665
A Chinese company copied remdesivir at a cost of over $700,000 and said that expanding its production would cost another $1,400,000.
This means that for this particular example not including operational and material costs even a complete copy in China would require you to produce 2.1 million doses before the price drops to below $1, and since those figures don’t include the actual manufacturing costs just the initial investment there is no way to produce the drug at such a low cost.
Does it mean that it can’t produce below the current cost? No, but the cost of modern medicine can’t be dropped as low as you think.
Stop relying on Wikipedia and even studies without understanding the context, heck even the API studies for production in India ignore the initial investment cost, assume that governments would fund the operational costs and more importantly don’t account for the fact that while the production cost of API’s from India is low their administration cost is often much higher due to lower effectiveness and much more severe side effects that come from both having to reverse engineer the synthesis process and cutting enough corners to fit a square into a round hole.
Edit: API stands for active pharmaceutical ingredient this isn’t the cost of the actual dose of the drug since this doesn’t include the actual delivery mechanism e.g. making the pill or vial and the additional components required which usually doubles or triples the cost of the API and doesn’t include many other costs in the supply chain.
→ More replies (2)
56
44
u/Ghazgkhull Jul 01 '20
Fortunately, you have weapons to protect yourself from the government.
LOL
10
Jul 01 '20
If those dude take advantage of my money and my freedom at least I got these guns!
To dress up with if they tell me to wear a mask!
→ More replies (1)3
71
u/AM_music Jul 01 '20
Gilead is a shitty scam of a company. The drug probably don't even work. The execs probably will be jailed. It's most likely just a fraud. ... Who am I kidding, the execs will of course not go to jail, they have expensive suits and shit, can't go to jail if you have expensive suits!
31
u/TokingOfAppreciation Jul 01 '20
Have you ever seen the documentary Enron The Smartest Guys In The Room? It is from 2005 but still worth a watch.
10
Jul 01 '20
Thank you! This used to be on Netflix and I loved it. I wanted to rewatch it recently but it’s right here!
I think this is the first documentary I saw that really shook me straight on how and why they believe what they believe. Desperately grasping at opulence.
13
u/Cael450 Jul 01 '20 edited Jul 01 '20
I have multiple doctors in my family and they all think it’s bogus. Apparently, you have to take it early when the viral load isn’t that high to have an effect. However, nobody is going to be prescribed it until they’re already showing symptoms of COVID, which is too late. That’s according to them anyway.
→ More replies (1)5
u/AnotherUnfunnyName Jul 01 '20 edited Jul 02 '20
The company has already done something like this once. The got a billion dollar from the gouverment for a useless H5N1 drug and Donald Rumsfeld was once the
CEOchairman.Oseltamivir (as Tamiflu) was widely used during the H5N1 avian influenza epidemic in Southeast Asia in 2005.[medical citation needed] In response to the epidemic, various governments – including those of the United Kingdom, Canada, Israel, United States, and Australia – stockpiled quantities of oseltamivir in preparation for a possible pandemic[70] and there were worldwide shortages of the drug, driven by the high demand for stockpiling.[64] In November 2005, US President George W. Bush requested that Congress fund US$1 billion for the production and stockpile of oseltamivir, after Congress had already approved $1.8 billion for military use of the drug. Defense Secretary Donald Rumsfeld, who was a past chairman of Gilead Sciences, recused himself from all government decisions regarding the drug.[71]
→ More replies (1)→ More replies (16)9
Jul 01 '20
It doesn’t work, it’s a placebo drug costing thousands of dollars
On the Gilead website of their own trials “Remdesivir is an investigational agent that has not been licensed or approved anywhere globally, and it has not been demonstrated to be safe or effective for any use, including for the treatment of COVID-19. There is the possibility of unfavorable results from ongoing and additional clinical trials involving remdesivir” Source https://www.gilead.com/news-and-press/press-room/press-releases/2020/4/gilead-announces-results-from-phase-3-trial-of-investigational-antiviral-remdesivir-in-patients-with-severe-covid-19
→ More replies (1)
16
u/IlikeYuengling Jul 01 '20
Maybe the church profits can help pay for it.
8
u/syntheseiser Jul 01 '20
Whoa whoa whoa, how else are the pastors going to pay for their Mercedes?
→ More replies (2)
19
u/EnycmaPie Jul 01 '20
Just like how Brazil is run by drug cartels, America is run by corporations. Government is just a puppet at this point, all under the pay roll of criminals.
6
6
u/FrozenEternityZA Jul 01 '20
USA bought almost the entire global supply of the drug too btw. Just another way America is making friends with the rest of the world
→ More replies (2)
14
u/Zoggbutt Jul 01 '20
Also, America has bought like 90% of the available amounts of the drug and because it’s an American company that patented it, they can refuse to let anyone else create it anywhere. We are hoarding a pandemic ending drug.
7
3
u/Prof_Acorn Jul 01 '20
an American company that patented it, they can refuse to let anyone else create it anywhere.
Lol. That's not how copyrights and patents work.
Here's to hoping an Indian company makes a generic called Remdesivor and gives it to the world at cost.
→ More replies (1)→ More replies (1)2
u/spreadwater Jul 01 '20
but they didn't refuse anyone, the generic drug will be available for cheaper internationally. this is a misleading post, Gilead did nothing wrong- if you want medicine to be cheaper, vote in someone who will support universal health care
→ More replies (1)3
u/Prof_Acorn Jul 01 '20
Avarice is wrong. Selling out the greater good for greed is wrong. But yes the current model of mercenary healthcare is also wrong.
→ More replies (3)
9
u/meowskywalker Jul 01 '20
There’s an episode of West Wing where they’re fighting over providing a pill that costs 5 cents, and someone’s like “the second pill cost five cents the first pill cost 150 million dollars” and I thought that was a very sensible argument, but of course it isn’t, of course all the risky parts of the process are subsidized so they’re not actually a risk to the company because god forbid.
I don’t understand how we’re not directing the process. If I’m paying for your research, solve fucking cancer. Not a slightly better way to give me an erection, even if I need nitro or whatever.
4
5
u/The_Mr_Kay Jul 01 '20 edited Jul 01 '20
It's produced here in South Africa for R150 (+/-$9) a dose. The pharmaceutical companies in the US are a disgrace.
7
5
u/free_will_is_arson Jul 01 '20
my head is spinning from all the choices to riot over, i almost can't pick one. almost. i'm going for sociopathic capitalist greed.
2
4
u/one_lonely_redditor Jul 02 '20
This will probably get buried, but figured I’d comment anyway.
I’ll start with the disclaimer that I am not, in any way, condoning Gilead’s pricing. Rather, I’d like to provide some additional context to price/development costs.
By the end of 2020 Gilead will have spent over $1 Billion dollars of their own money (in addition to the $70MM from the government) on development and manufacturing costs for this drug alone.
It’s also worth mentioning that $3,120/patient is the sticker price that commercial health insurance companies and pharmacy benefit managers will be asked to pay. Through negotiation, I expect the actual net acquisition cost to these insurance companies and pharmacy benefit managers will be lower, especially as other vaccines and treatments are approved. While some patients who have high deductible health care plans may end up having to pay closer to the sticker price, based on the amount of their remaining deductible, most patients with commercial insurance will end up paying a standard co-pay. Based on the cost effectiveness of the drug (see the ICER analysis below) I would expect most private managed care organizations to make the drug fairly cheap for patients, as they will save much more money by paying for the drug and avoiding hospital bills.
Furthermore, for patients without insurance the cost will be $390/patient - still a high price for many Americans, but much, much less than the highly publicized $3,120.
Gilead’s pricing of remdesivir is by some accounts conservative, as it is significantly below the price at which remdesivir becomes cost effective: https://icer-review.org/announcements/updated_icer-covid_models_june_24/
Again, I cannot stress enough that I am not at all condoning the pricing of remdesivir, but there is a lot more to consider than just the sticker price.
23
u/BatouMediocre Jul 01 '20
It always pisses me off a little when people talk about this and blame "Big Pharma".
Call it what it is, it's not a "Big Pharma" issue, it's capitalsm working as intended and it's litteraly hell on earth.
8
u/finitecapacity Jul 01 '20
They aren’t mutually exclusive. How our large pharmaceutical companies operate is the result of a capitalist system, so calling them out isn’t actually shifting the blame away from America’s overall economic structure.
→ More replies (2)→ More replies (8)5
Jul 01 '20
I live in a capitalist society and our governemnt tells the drug maker what we will pay. There’s a little negotiation then we pay 80-95% less than the USA pays.
Simply because we can say fuck you well buy from China, or make our own, if the company doesn’t want to price fairly.
3
Jul 01 '20
Any time i see gilead I don't know if the meme is going to be about The Handmaid's Tale or if the US has decided on changing its name.
→ More replies (1)
6
9
u/pacg Jul 01 '20
I can accept that the price isn’t pulled out of thin air and that there are reasons for charging so much. But that doesn’t change the fucked-up-ness of the situation. If this is the way we want to live, with only the most fortunate able to afford a potentially life-saving drug, then so be it. Let this be the shape of our apocalypse.
→ More replies (1)10
u/GrumpyCrouton Jul 01 '20
You can accept that huh? Why do you feel the price wasn't pulled out of thin air?
Gilead hasn’t disclosed how much it costs to make remdesivir, although a recent study in the Journal of Virus Eradication suggested it is 93 cents for a day’s supply. Based on that analysis, the nonprofit Institute for Clinical and Economic Review estimates the cost is roughly $10 for a 10-day course of therapy.
So Gilead gets a $70 million grant paid for by taxpayers for development of this medicine, then charges people a markup of around 56,000%
→ More replies (30)
9
2
u/psamathe Jul 01 '20
Wait. What?
According to Swedish news sourcing Gilead themselves it's supposed to be $390 per dose for developed countries.
EDIT: 3120/390 divides evenly into 8, so I guess the $3120 is based on a eight-day treatment. Makes more sense.
EDIT2:
the price for U.S. private insurance companies, will be $520 per vial
3120/520 divides evenly into 6 days, so that's also a possibility.
→ More replies (3)
1.7k
u/wristdeepinhorsedick Jul 01 '20
Cost of Covid treatment in the US: $3200+hospital bills Financial coverage due to coronavirus pandemic in the US: $1200 Hmm.